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No Recurrences in Selected Patients after Curettage with Cryotherapy for Grade I Chondrosarcomas

  • Clinical Research
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Clinical Orthopaedics and Related Research®



The low aggressiveness of Grade I chondrosarcomas is compatible with conservative surgical treatment.


We asked whether combined curettage and cryotherapy would yield low rates of recurrence and whether supplemental internal fixation would retain function with low rates of complications in patients with Grade I central chondrosarcomas of the proximal humerus or distal femur.


We retrospectively reviewed 15 patients: nine women and six men with a mean age of 45 years (range, 26–70 years). All patients underwent curettage and cryosurgery through a cortical window; we replaced the window and plated the region with at least three screws beyond the curetted area. None of the patients was lost to followup, and 14 patients (93%) were reexamined by us after a minimum of 5 years (mean, 8 years; range, 5–11 years).


There were no perioperative anesthetic, neurologic, hardware, or healing complications. None of the patients had local recurrence or metastases develop. At last followup, the Musculoskeletal Tumor Society score was 27.9 (range, 22–30) and all patients had resumed their previous activities. No complications were associated with this simplified cryotherapy technique.


The data confirm the appropriateness of conservative surgery for central low-grade chondrosarcomas of the proximal humerus and distal femur based on a combination of intralesional curettage and cryogenic parietal sterilization. Candidates for this approach should be chosen on the basis of the affected bone site, local extension staging, and clinicopathologic grading. We recommend supplementary internal fixation.

Level of Evidence

Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

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We thank Gérard Lancien MD, for the first histopathologic evaluation (1997–2002).

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Correspondence to Hervé Thomazeau MD.

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Frantz Langlais—Deceased.

Each author certifies that he or she has no commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangement, etc) that might pose a conflict of interest in connection with the submitted article.

Each author certifies that his or her institution has approved the reporting of these cases, that all investigations were conducted in conformity with ethical principles of research, and that informed consent was obtained.

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Souna, B.S., Belot, N., Duval, H. et al. No Recurrences in Selected Patients after Curettage with Cryotherapy for Grade I Chondrosarcomas. Clin Orthop Relat Res 468, 1956–1962 (2010).

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