Clinical Orthopaedics and Related Research®

, Volume 468, Issue 6, pp 1493–1497 | Cite as

The Effect of Hypercholesterolemia on Rotator Cuff Disease

  • Joseph A. AbboudEmail author
  • Jae S. Kim
Symposium: Current Concepts in Rotator Cuff Disease and Treatment



The causes of rotator cuff tendon rupture are multifactorial and still unclear. Intrinsic and extrinsic factors have been implicated as predisposing risk factors for rotator cuff rupture. Previous studies have suggested a relationship between elevated serum lipid profiles and tendon ruptures, although not rotator cuff tears specifically.


We therefore asked whether patients with rotator cuff tears were more likely to have higher levels of hypercholesterolemia than patients with shoulder pain but without tears.


We prospectively collected serum cholesterol and lipid profiles on two age-matched populations of patients; 74 (mean age, 66.3 years) had ruptures of their rotator cuff tendons, whereas a control group of 73 patients (mean age, 67.4 years) were seen for nontendon-related shoulder complaints.


Total cholesterol, triglycerides, and low-density lipoprotein cholesterol concentrations of the patients with rotator cuff tendon tears were higher, and their high-density lipoprotein cholesterol showed a trend to being lower than the control group. Forty-seven of 74 patients (63%) with rotator cuff tears had an elevated serum cholesterol (total cholesterol greater than 240 mg/dL) as compared with an overall rate of 28% in our control group.


Patients with rotator cuff tears were more likely to have hypercholesterolemia when compared with the control group.

Clinical relevance

Measurement of serum cholesterol in patients presenting with torn rotator cuff tendons should be considered in patients whose cholesterol profiles are unknown. Future consideration of drug treatment may reduce risk for future tendon degeneration, as well as improve quality of life and reduce mortality.

Level of Evidence

Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence.


Rotator Cuff Shoulder Pain Rotator Cuff Tear Tendon Rupture Proximal Humerus Fracture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank William J. Warrender for his help with manuscript editing.


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Copyright information

© The Association of Bone and Joint Surgeons® 2009

Authors and Affiliations

  1. 1.University of Pennsylvania Health System, 3B Orthopaedics, Pennsylvania HospitalPhiladelphiaUSA

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