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Table 1  

From: The Classic: Registry of Bone Sarcoma: Part I.—Twenty-Five Criteria for Establishing the Diagnosis of Osteogenic Sarcoma. Part II.—Thirteen Registered Cases of “Five Year Cures” Analyzed According to These Criteria

Criteria Hubbard Rixford Wells Bloodgood and Coley Bloodgood Bloodgood Coley Coley Thompson Coley Bloodgood Coley Coley
Case number 29 50 64 100 101 102 172 184 261 408 501 586 183
History
    1. Onset with pain—not fracture or tumor 0 0 + + 0 0 + 0 + +   0 +
    2. Duration. Not years or weeks but months 0 0 + + + + + + + +   0 +
    3. General condition—health at first + + + + + + + + + +   0 +
    4. Age. Not over 50 unless Paget’s + + + + + + + + + +   + +
    5. Rapid growth—month by month + 0 + + + + + + + +   0 +
Examination
    1. Immobility of soft parts + 0 + + +   + + + +   + +
    2. Location—certain bones rare + + + + + + + + + +   0 +
    3. No inflammatory signs + + 0 + 0 + + + + +   + 0
    4. Joint not affected + + + + 0   +   + +   + +
    5. Size and shape (not pedunculated) + + + + + + + + + +   + +
X-ray
    1. Both, central and subperiosteal—not either alone     +    +      + +
    2. Old shaft present—not expanded     +    +      0 +
    3. Invasive—no rounded contours to spongy bone     +    +      + +
    4. Osteolytic and osteoblastic—not either alone.     +    +      + +
    5. Soft parts involved—at least extracortical     +    0      + +
Microscopic
    1. Mitoses (hyperchromatism) + + + + + + + 0 + + + + +
    2. Pleomorphism + + + + + + + + + + + + +
    3. Tumor giant cells + + + + 0 + + + + +   + +
    4. Differentiation—partial + + + 0 + + + 0 + + + + +
    5. Tumor vessels + +   + + + + + + + + + +
General
    1. Nature of pathological examination + 0 0 + + 0 + + + 0 0 + 0
    2. Quality of data in general 0 0 + + 0 0 + 0 + + 0 + +
    3. Unanimity of specialists + + + + 0 + + 0 + 0 0 0 +
    4. The registry classification + + + + + + + + + + + + +
    5. The ultimate result 0 0 0 0 0 0 0 0 0 0 0 0 0