Clinical Orthopaedics and Related Research

, Volume 466, Issue 3, pp 729–736 | Cite as

Predictors of Survival in Patients With Bone Metastasis of Lung Cancer

  • Hideshi SugiuraEmail author
  • Kenji Yamada
  • Takahiko Sugiura
  • Toyoaki Hida
  • Tetsuya Mitsudomi
Original Article Tumor


The prognosis of patients with bone metastasis from lung cancer has not been well documented. We assessed the survival rates after bone metastasis and prognostic factors in 118 patients with bone metastases from lung cancer. The cumulative survival rates after bone metastasis from lung cancer were 59.9% at 6 months, 31.6% at 1 year, and 11.3% at 2 years. The mean survival was 9.7 months (median, 7.2 months; range, 0.1–74.5 months). A favorable prognosis was more likely in women and patients with adenocarcinoma, solitary bone metastasis, no metastases to the appendicular bone, no pathologic fractures, performance status 1 or less, use of systemic chemotherapy, and use of an epithelial growth factor receptor inhibitor. Analyses of single and multiple variables indicated better prognoses for patients with adenocarcinoma, no evidence of appendicular bone metastases, and treatment with an epithelial growth factor receptor inhibitor. The mean survival period was longer in a small group treated with an epithelial growth factor receptor inhibitor than in the larger untreated group. The data preliminarily suggest treatment with an epithelial growth factor receptor inhibitor may improve survival after bone metastasis.

Level of Evidence: Level IV, prognostic study. See the Guidelines for Authors for a complete description of levels of evidence.


Lung Cancer Bone Metastasis Gefitinib Pathologic Fracture Cumulative Survival Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank Mitsuko Yokouchi and Kiyonori Kuriki for statistical assistance and Shoko Miyachi for administrative assistance in the preparation of this manuscript.


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Copyright information

© The Association of Bone and Joint Surgeons 2008

Authors and Affiliations

  • Hideshi Sugiura
    • 1
    Email author
  • Kenji Yamada
    • 1
  • Takahiko Sugiura
    • 2
  • Toyoaki Hida
    • 3
  • Tetsuya Mitsudomi
    • 4
  1. 1.Department of Orthopaedic SurgeryAichi Cancer CenterChikusa-kuJapan
  2. 2.Department of Respiratory DiseaseAichi Circulation and Respiratory CenterNagoya CityJapan
  3. 3.Department of Respiratory DiseaseAichi Cancer CenterNagoya CityJapan
  4. 4.Department of Thoracic SurgeryAichi Cancer CenterNagoya CityJapan

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