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The development of coatings using combinatorial/high throughput methods: a review of the current status

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Abstract

Combinatorial chemistry is a relatively new experimental methodology developed by academics and researchers in the pharmaceutical industry to reduce the time and cost associated with drug development. Basically, combinatorial chemistry involves the rapid synthesis and evaluation of large numbers of compounds in parallel using robotics, rapid analytical instrumentation, and data management software. More recently, the principles of combinatorial chemistry have been applied to materials development, and interest in this area is increasing rapidly. This interest can be attributed to the potential for obtaining a major competitive advantage by implementing a combinatorial approach. This document provides an introduction to combinatorial materials science and provides a review of efforts aimed at developing combinatorial workflows for coating development. While the application of combinatorial methods to coating development is still in its infancy, full combinatorial workflows have been developed within a few different organizations.

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Acknowledgments

The authors acknowledge the Office of Naval Research (grant N00014-05-1-0822) and the Air Force Research Laboratory (grants FA8650-04-1-5045 and RSC02050) for financial support of the preparation of this document.

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Authors and Affiliations

  1. Center for Nanoscale Science and Engineering, North Dakota State University, 1805 Research Park Drive, Fargo, ND, 58102, USA

    Bret J. Chisholm

  2. Department of Coatings and Polymeric Materials, North Dakota State University, 1735 Research Park Drive, Fargo, ND, 58105, USA

    Dean C. Webster

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  2. Dean C. Webster
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Correspondence to Bret J. Chisholm.

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Chisholm, B.J., Webster, D.C. The development of coatings using combinatorial/high throughput methods: a review of the current status. J Coat Technol Res 4, 1–12 (2007). https://doi.org/10.1007/s11998-007-9000-9

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