Abstract
The in situ radical polymerization technique has been used for synthesizing different amounts of hydroxyapatite (HAp)–doped polyhydroxyethylmethacrylate (PHEMA) films. Film-formed hydrogels were obtained, then the investigation of swelling behavior and moisture contents of composite hydrogels in aqueous solutions was carried out. The morphological and structural properties of the obtained films have been characterized by FT-IR and UV–Vis. spectrophotometer, XRD, and SEM analysis. Obtained films have shown transparent and semitransparent properties, which caused excellent UV–Vis. barrier properties. Gas transmission qualification of the films was evaluated by C, H, and N elemental analysis. HAp-doped and undoped PHEMA films were tested on cherry tomatoes as smart packaging materials. The result of the application test exhibits that these films are suitable for use as a preservative packaging of vegetables because of their visual integrity. In this way, the whole of these characterization and test results elicits the increase of shelf life of cherry tomatoes and reduction of pathogenic caused by food with HAp-doped PHEMA smart porous materials. This study presents HAp-doped PHEMA films as alternative packaging material instead of existing materials, which has a negative environmental impact.
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References
Abdolsattari, P., Rezazadeh-Bari, M., & Pirsa, S. (2022). Smart film based on polylactic acid, modified with polyaniline/ZnO/CuO: Investigation of physicochemical properties and its use of intelligent packaging of orange juice. Food and Bioprocess Technology, 15(12), 2803–2825. https://doi.org/10.1007/s11947-022-02911-3
Ahmed, E. M. (2015). Hydrogel: Preparation, characterization, and applications: A review. Journal of Advanced Research, 6(2), 105–121. https://doi.org/10.1016/j.jare.2013.07.006
Alam, A., Zhang, Y., Kuan, H. C., Lee, S. H., & Ma, J. (2018). Polymer composite hydrogels containing carbon nanomaterials—morphology and mechanical and functional performance. Progress in Polymer Science, 77, 1–18. https://doi.org/10.1016/J.PROGPOLYMSCI.2017.09.001
Albahr, Z., Al-Ghamdi, S., Tang, J., & Sablani, S. S. (2022). Pressure-assisted thermal sterilization and storage stability of avocado puree in high barrier polymeric packaging. Food and Bioprocess Technology, 15(11), 2616–2628. https://doi.org/10.1007/s11947-022-02904-2
Appendini, P., & Hotchkiss, J. H. (2002). Review of antimicrobial food packaging. Innovative Food Science & Emerging Technologies, 3(2), 113–126. https://doi.org/10.1016/S1466-8564(02)00012-7
Argin, S., Kofinas, P., & Lo, Y. M. (2014). The cell release kinetics and the swelling behavior of physically crosslinked xanthan–chitosan hydrogels in simulated gastrointestinal conditions. Food Hydrocolloids, 40, 138–144. https://doi.org/10.1016/J.FOODHYD.2014.02.018
Batista, R. A., Judith, P., Espitia, P., Souza, J. D., Quintans, S., Machado, M., et al. (2019). Hydrogel as an alternative structure for food packaging systems. Carbohydrate Polymers, 205, 106–116. https://doi.org/10.1016/j.carbpol.2018.10.006
Bayramoǧlu, G., Kaya, B., & Arica, M. Y. (2002). Procion brown mx-5br attached and lewis metals ion-immobilized poly(hydroxyethyl methacrylate)/chitosan ipns membranes: Their lysozyme adsorption equilibria and kinetics characterization. Chemical Engineering Science, 57(13), 2323–2334. https://doi.org/10.1016/S0009-2509(02)00141-0
Caló, E., & Khutoryanskiy, V. V. (2015). Biomedical applications of hydrogels: A review of patents and commercial products. European Polymer Journal, 65, 252–267. https://doi.org/10.1016/J.EURPOLYMJ.2014.11.024
Castro, K. A. D. F., Moura, N. M. M., Simões, M. M. Q., Cavaleiro, J. A. S., Faustino, A. F., Cunha, Â., et al. (2019). Synthesis and characterization of photoactive porphyrin and poly (2-hydroxyethyl methacrylate ) based materials with bactericidal properties. Applied Materials Today, 16, 332–341. https://doi.org/10.1016/j.apmt.2019.06.010
Chang, C., Duan, B., Cai, J., & Zhang, L. (2010). Superabsorbent hydrogels based on cellulose for smart swelling and controllable delivery. European Polymer Journal, 46(1), 92–100. https://doi.org/10.1016/J.EURPOLYMJ.2009.04.033
Chaudhuri, B., Mondal, B., Ray, S. K., & Sarkar, S. C. (2016). A novel biocompatible conducting polyvinyl alcohol (PVA)-polyvinylpyrrolidone (PVP)-hydroxyapatite (HAP) composite scaffolds for probable biological application. Colloids and Surfaces B: Biointerfaces, 143, 71–80. https://doi.org/10.1016/j.colsurfb.2016.03.027
Dainelli, D., Gontard, N., Spyropoulos, D., Zondervan-van den Beuken, E., & Tobback, P. (2008). Active and intelligent food packaging: Legal aspects and safety concerns. Trends in Food Science & Technology, 19(SUPPL. 1), S103–S112. https://doi.org/10.1016/J.TIFS.2008.09.011
Demarco, F., Rômio, A. P., da Trindade Alfaro, A., & Tonial, I. B. (2022). Effects of natural antioxidants on the lipid oxidation, physicochemical and sensory characteristics, and shelf life of sliced salami. Food and Bioprocess Technology, 15(10), 2282–2293. https://doi.org/10.1007/s11947-022-02877-2
Dilkes-Hoffman, L. S., Pratt, S., Laycock, B., Ashworth, P., & Lant, P. A. (2019). Public attitudes towards plastics. Resources, Conservation and Recycling, 147, 227–235. https://doi.org/10.1016/j.resconrec.2019.05.005
Dinu, M. V., Cocarta, A. I., & Dragan, E. S. (2016). Synthesis, characterization and drug release properties of 3D chitosan/clinoptilolite biocomposite cryogels. Carbohydrate Polymers, 153, 203–211. https://doi.org/10.1016/J.CARBPOL.2016.07.111
Dragan, E. S., & Dinu, M. V. (2020). Advances in porous chitosan-based composite hydrogels : Synthesis and applications. Reactive and Functional Polymers, 146, 104372. https://doi.org/10.1016/j.reactfunctpolym.2019.104372
Duarte, L. G. R., Ferreira, N. C. A., Fiocco, A. C. T. R., & Picone, C. S. F. (2022). Lactoferrin-chitosan-TPP nanoparticles: Antibacterial action and extension of strawberry shelf-life. Food and Bioprocess Technology, 135–148. https://doi.org/10.1007/s11947-022-02927-9
El Miri, N., Abdelouahdi, K., Barakat, A., Zahouily, M., Fihri, A., Solhy, A., & El Achaby, M. (2015). Bio-nanocomposite films reinforced with cellulose nanocrystals: Rheology of film-forming solutions, transparency, water vapor barrier and tensile properties of films. Carbohydrate Polymers, 129, 156–167. https://doi.org/10.1016/J.CARBPOL.2015.04.051
Emir, A. A., Yildiz, E., Aydogdu, Y., & Sumnu, G. (2022). Active films based on Faba Bean (Vicia faba L.) flour incorporated with Sumac (Rhus coriaria): Assessment of antioxidant and antimicrobial performances of packaging for shelf life of chicken breast. Food and Bioprocess Technology, 327–341. https://doi.org/10.1007/s11947-022-02940-y
Fernández, A., Soriano, E., López-Carballo, G., Picouet, P., Lloret, E., Gavara, R., & Hernández-Muñoz, P. (2009). Preservation of aseptic conditions in absorbent pads by using silver nanotechnology. Food Research International, 42(8), 1105–1112. https://doi.org/10.1016/J.FOODRES.2009.05.009
Friedrich, D. (2020). How regulatory measures towards biobased packaging influence the strategic behaviour of the retail industry: A microempirical study. Journal of Cleaner Production, 260, 121128. https://doi.org/10.1016/j.jclepro.2020.121128
Gao, P., Cha, R., Luo, H., Xu, Y., Zhang, P., Han, L., et al. (2021). Development of antimicrobial oxidized cellulose film for active food packaging. Carbohydrate Polymers, 118922. https://doi.org/10.1016/j.carbpol.2021.118922
Gokmen, F. O., Yaman, E., & Temel, S. (2021). Eco-friendly polyacrylic acid based porous hydrogel for heavy metal ions adsorption: Characterization, adsorption behavior, thermodynamic and reusability studies. Microchemical Journal, 168, 106357. https://doi.org/10.1016/j.microc.2021.106357
Haghighi, H., Gullo, M., La China, S., Pfeifer, F., Siesler, H. W., Licciardello, F., & Pulvirenti, A. (2021). Characterization of bio-nanocomposite films based on gelatin/polyvinyl alcohol blend reinforced with bacterial cellulose nanowhiskers for food packaging applications. Food Hydrocolloids, 113, 106454. https://doi.org/10.1016/j.foodhyd.2020.106454
Haghighi, H., Leugoue, S. K., Pfeifer, F., Siesler, H. W., Licciardello, F., Fava, P., & Pulvirenti, A. (2020). Development of antimicrobial films based on chitosan-polyvinyl alcohol blend enriched with ethyl lauroyl arginate (LAE) for food packaging applications. Food Hydrocolloids, 100, 105419. https://doi.org/10.1016/j.foodhyd.2019.105419
Hebeish, A., Hashem, M., El-hady, M. M. A., & Sharaf, S. (2013). Development of CMC hydrogels loaded with silver nano-particles for medical applications. Carbohydrate Polymers, 92(1), 407–413. https://doi.org/10.1016/j.carbpol.2012.08.094
Huang, J., Lyu, S., Fu, F., Wu, Y., & Wang, S. (2017). Green preparation of a cellulose nanocrystals/ polyvinyl alcohol composite superhydrophobic coating. RSC Advances, 7(33), 20152–20159. https://doi.org/10.1039/c6ra27663f
Hui, J., Li, H., Zheng, X., Ma, H., Fan, D., Liu, H., & Wang, Y. (2015). Control synthesis and self-assembly of calcium apatite at low temperatures. Ceramics International, 41(5), 6194–6202. https://doi.org/10.1016/j.ceramint.2014.12.156
Jayakumar, A., K.V., H., T.S., S., Joseph, M., Mathew, S., G., P., et al. (2019). Starch-PVA composite films with zinc-oxide nanoparticles and phytochemicals as intelligent pH sensing wraps for food packaging application. International Journal of Biological Macromolecules, 136, 395–403. https://doi.org/10.1016/j.ijbiomac.2019.06.018
Kameshwar, A. K. S., & Qin, W. (2016). Recent developments in using advanced sequencing technologies for the genomic studies of lignin and cellulose degrading microorganisms. International Journal of Biological Sciences, 12(2), 156–171. https://doi.org/10.7150/ijbs.13537
Koçyiǧit, S., Gökmen, Ö., Temel, S., Aytimur, A., Uslu, I., & Haman Bayari, S. (2013). Structural investigation of boron undoped and doped indium stabilized bismuth oxide nanoceramic powders. Ceramics International, 39(7), 7767–7772. https://doi.org/10.1016/j.ceramint.2013.03.035
Koenig-Lewis, N., Grazzini, L., & Palmer, A. (2022). Cakes in plastic: A study of implicit associations of compostable bio-based versus plastic food packaging. Resources, Conservation and Recycling, 178, 105977. https://doi.org/10.1016/j.resconrec.2021.105977
Li, S., Sun, X., Li, H., & Yan, S. (2018). The crystallization behavior of biodegradable polymer in thin fi lm. European Polymer Journal, 102, 238–253. https://doi.org/10.1016/j.eurpolymj.2018.03.029
Liu, B., Xu, H., Zhao, H., Liu, W., Zhao, L., & Li, Y. (2017). Preparation and characterization of intelligent starch/PVA films for simultaneous colorimetric indication and antimicrobial activity for food packaging applications. Carbohydrate Polymers, 157, 842–849. https://doi.org/10.1016/j.carbpol.2016.10.067
Liu, J., Cheng, D., Zhang, D., Han, L., Gan, Y., Zhang, T., & Yu, Y. (2022). Incorporating ε-polylysine hydrochloride, tea polyphenols, nisin, and ascorbic acid into edible coating solutions: Effect on quality and shelf life of marinated eggs. Food and Bioprocess Technology, 15(12), 2683–2696. https://doi.org/10.1007/s11947-022-02908-y
Luo, Y., Su, J., Guo, S., Cao, Z., Liu, Z., Wu, S., et al. (2022). Preparation of humidity-responsive cinnamon essential oil nanomicelles and its effect on postharvest quality of strawberries. Food and Bioprocess Technology, 15(12), 2723–2736. https://doi.org/10.1007/s11947-022-02906-0
Ma, W., Li, L., Xiao, X., Du, H., Ren, X., Zhang, X., et al. (2020). 2000228 (1 of 9) Construction of chlorine labeled ZnO-chitosan loaded cellulose nanofibrils film with quick antibacterial performance and prominent UV stability. Macromolecular Materials and Engineering, 305, 2000228. https://doi.org/10.1002/mame.202000228
Mahroug, H., Mansri, A., & Dergal, F. (2019). The effect of calcium suspension concentration on the hydroxyapatite structures and purity. Revue Roumaine de Chimie, 64(3), 277–286. https://doi.org/10.33224/rrch/2019.64.3.10
Mansri, A., Mahroug, H., & Dergal, F. (2019). In situ preparation of hydroxyapatite composites into hydrolyzed polyacrylamide solution and methylene blue dye retention. Turkish Journal of Chemistry, 43(2), 582–593. https://doi.org/10.3906/kim-1803-49
Mary, I. R., Sonia, S., Viji, S., Mangalaraj, D., Viswanathan, C., & Ponpandian, N. (2016). Novel multiform morphologies of hydroxyapatite: Synthesis and growth mechanism. Applied Surface Science, 361, 25–32. https://doi.org/10.1016/j.apsusc.2015.11.123
Misra, K., & S., P. Valappil, S., Roy, I., & R. Boccaccini, A. (2006). Polyhydroxyalkanoate (PHA)/inorganic phase composites for tissue engineering applications. Biomacromolecules, 7(8), 2249–2258. https://doi.org/10.1021/bm060317c
Min, T., Zhu, Z., Sun, X., Yuan, Z., Zha, J., & Wen, Y. (2020). Highly efficient antifogging and antibacterial food packaging film fabricated by novel quaternary ammonium chitosan composite. Food Chemistry, 308, 125682. https://doi.org/10.1016/j.foodchem.2019.125682
Montheard, J. -P., Chatzopoulos, M., & Chappard, D. (1992). 2-Hydroxyethyl methacrylate (HEMA): Chemical properties and applications in biomedical fields. Journal of Macromolecular Science, Part C, 32(1), 1–34. https://doi.org/10.1080/15321799208018377
Muratore, F., Barbosa, S. E., & Martini, R. E. (2019). Development of bioactive paper packaging for grain-based food products. Food Packaging and Shelf Life, 20, 100317. https://doi.org/10.1016/j.fpsl.2019.100317
Nair, L. S., & Laurencin, C. T. (2007). Biodegradable polymers as biomaterials. Progress in Polymer Science, 32(8–9), 762–798. https://doi.org/10.1016/J.PROGPOLYMSCI.2007.05.017
Nguyen, H., Hong, T., Tan, L., Jeon, H., & Oh, D. X. (2021). Biorenewable , transparent , and oxygen / moisture barrier nanocellulose / nanochitin-based coating on polypropylene for food packaging applications. Carbohydrate Polymers, 271, 118421. https://doi.org/10.1016/j.carbpol.2021.118421
Otoni, C. G., Espitia, P. J. P., Avena-Bustillos, R. J., & McHugh, T. H. (2016). Trends in antimicrobial food packaging systems: Emitting sachets and absorbent pads. Food Research International, 83, 60–73. https://doi.org/10.1016/J.FOODRES.2016.02.018
Oyen, M. L. (2014). Mechanical characterisation of hydrogel materials. International Materials Reviews, 59(1), 44–59. https://doi.org/10.1179/1743280413Y.0000000022
Ozdemir, M., & Floros, J. D. (2004). Active food packaging technologies. Critical Reviews in Food Science and Nutrition, 44(3), 185–193. https://doi.org/10.1080/10408690490441578
Pereira, A. T., Henriques, P. C., Costa, P. C., Martins, M. C. L., Magalhães, F. D., & Gonçalves, I. C. (2019). Graphene oxide-reinforced poly(2-hydroxyethyl methacrylate) hydrogels with extreme stiffness and high-strength. Composites Science and Technology, 184, 107819. https://doi.org/10.1016/j.compscitech.2019.107819
Piyada, K., Waranyou, S., & Thawien, W. (2013). Mechanical, thermal and structural properties of rice starch films reinforced with rice starch nanocrystals. International Food Research Journal, 20(1), 439–449.
Rooney, M. L. (2005). Introduction to active food packaging technologies. Innovations in Food Packaging, 63–79. https://doi.org/10.1016/B978-012311632-1/50037-1
Shahabi-Ghahfarrokhi, I., & Babaei-Ghazvini, A. (2019). Using photo-modification to compatibilize nano-ZnO in development of starch-kefiran-ZnO green nanocomposite as food packaging material. International Journal of Biological Macromolecules, 124, 922–930. https://doi.org/10.1016/j.ijbiomac.2018.11.241
Sumrin, S., Gupta, S., Asaad, Y., Wang, Y., Bhattacharya, S., & Foroudi, P. (2021). Eco-innovation for environment and waste prevention. Journal of Business Research, 122, 627–639. https://doi.org/10.1016/j.jbusres.2020.08.001
Suppakul, P., Sonneveld, K., Bigger, S. W., & Miltz, J. (2008). Efficacy of polyethylene-based antimicrobial films containing principal constituents of basil. LWT - Food Science and Technology, 41(5), 779–788. https://doi.org/10.1016/J.LWT.2007.06.006
Tang, Y., Hu, X., Zhang, X., Guo, D., Zhang, J., & Kong, F. (2016). Chitosan/titanium dioxide nanocomposite coatings: Rheological behavior and surface application to cellulosic paper. Carbohydrate Polymers, 151, 752–759. https://doi.org/10.1016/j.carbpol.2016.06.023
Temel, S., Gokmen, F. O., & Yaman, E. (2020). Antibacterial activity of ZnO nanoflowers deposited on biodegradable acrylic acid hydrogel by chemical bath deposition. Bulletin of Materials Science, 43(1), 1–6. https://doi.org/10.1007/s12034-019-1967-1
Temel, S., Gökmen, F., & Yaman, E. (2019a). An energy efficient way to produce zinc-based semiconductor thin films via chemical bath deposition technique. Journal of Sustainable Development of Energy, Water and Environment Systems, 7(2), 253–260. https://doi.org/10.13044/j.sdewes.d6.0239
Temel, S., Yaman, E., Ozbay, N., & Gokmen, F. O. (2019b). Synthesis, characterization and adsorption studies of nano-composite hydrogels and the effect of SiO2on the capacity for the removal of Methylene Blue dye. Journal of the Serbian Chemical Society, 85(7), 939–952. https://doi.org/10.2298/JSC190517114T
Thompson, J. M., Waites, W. M., & Dodd, C. E. R. (1998). Detection of rope spoilage in bread caused by bacillus species. Journal of Applied Microbiology, 85(3), 481–486. https://doi.org/10.1046/j.1365-2672.1998.853512.x
Vélez-Erazo, E. M., Carbajal-Sandoval, M. S., Sanchez-Pizarro, A. L., Peña, F., Martínez, P., & Velezmoro, C. (2022). Peruvian biopolymers (sapote gum, tunta, and potato starches) as suitable coating material to extend the shelf life of bananas. Food and Bioprocess Technology, 15(11), 2562–2572. https://doi.org/10.1007/s11947-022-02902-4
Wang, F., Chen, C., Wang, J., Xu, Z., Shi, F., & Chen, N. (2023). Facile preparation of PHEMA hydrogel induced via Tannic Acid-Ferric ions for wearable strain sensing. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 658, 130591. https://doi.org/10.1016/j.colsurfa.2022.130591
Wang, Y., Ouyang, H., Xie, Y., Jiang, Y., Zhao, L., Peng, W., et al. (2022). Mechanically robust, biocompatible, and durable PHEMA-based hydrogels enabled by the synergic effect of strong intermolecular interaction and suppressed phase separation. Polymer, 254, 125083. https://doi.org/10.1016/j.polymer.2022.125083
Wichterle, O., & Lím, D. (1960). Hydrophilic gels for biological use. Nature, 185(4706), 117–118. https://doi.org/10.1038/185117a0
Wu, M., Sukyai, P., Lv, D., Zhang, F., Wang, P., Liu, C., & Li, B. (2020). Water and humidity-induced shape memory cellulose nanopaper with quick response, excellent wet strength and folding resistance. Chemical Engineering Journal, 392(August 2019), 123673. https://doi.org/10.1016/j.cej.2019.123673
Yang, X., Huang, L., Zhou, L., Xu, H., & Yi, Z. (2016). A photochromic copolymer hydrogel contact lens: From synthesis to application. International Journal of Polymer Science, 2016(Cd). https://doi.org/10.1155/2016/4374060
Yavuz, M., Çakir, O., & Baysal, Z. (2016). Adsorption of cellulase on poly(2-hydroxyethyl methacrylate) cryogels containing phenylalanine. Turkish Journal of Chemistry, 40(5), 720–728. https://doi.org/10.3906/kim-1601-43
Youssef, A. M., El-Sayed, H. S., El-Sayed, S. M., Fouly, M., & El-Aziz, M. E. A. (2022). Novel bionanocomposites based on cinnamon nanoemulsion and TiO2-NPs for preserving fresh chicken breast fillets. Food and Bioprocess Technology, 356–367. https://doi.org/10.1007/s11947-022-02934-w
Zhang, L., Lyu, S., Zhang, Q., Wu, Y., Melcher, C., Chmely, S. C., et al. (2019). Dual-emitting film with cellulose nanocrystal-assisted carbon dots grafted SrAl2O4, Eu2+, Dy3+ phosphors for temperature sensing. Carbohydrate Polymers, 206, 767–777. https://doi.org/10.1016/j.carbpol.2018.11.031
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Fatma Özge Gökmen designed the study and the experimental setups. Fatma Özge Gökmen evaluated the characterization results and prepared all figures and tables in the manuscript. Fatma Özge Gökmen was the only one responsible for writing, editing, and reviewing the manuscript.
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Gökmen, F.Ö. Hydroxyapatite-Doped Polyhydroxyethylmethacrylate Hydrogels as Smart Porous Packaging Materials. Food Bioprocess Technol 16, 2692–2704 (2023). https://doi.org/10.1007/s11947-023-03097-y
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DOI: https://doi.org/10.1007/s11947-023-03097-y