Skip to main content

Development of a Novel Antimicrobial Electrospun Nanofiber Based on Polylactic Acid/Hydroxypropyl Methylcellulose Containing Pomegranate Peel Extract for Active Food Packaging

Abstract

In the present study, a new active electrospun nanofiber (NF) based on polylactic acid (PLA) and hydroxypropyl methylcellulose (HPMC) containing pomegranate peel extract (PPE) was developed as antimicrobial food packaging materials. Based on the results, by increasing the HPMC content from 5 to 20%, the solution viscosity increased and subsequently, a bead-free morphology with increasing NF diameter was observed. Therefore, PLA/HPMC NFs with ratio of 80:20 (optimal sample) were designated for delivery of PPE as the antioxidant and antibacterial agent. There was no significant change in the NF diameter by increasing the concentration of the PPE. The water contact angel (∼ 88.5°) of optimal NF decreased after increasing the concentration of the PPE (∼ 68.5°). Moreover, after the incorporation of the extract into the NFs, the thermal stability, tensile stress (7.33 MPa at dry state, and 11.54 MPa at wet state), porosity (∼ 90%), and water vapor transmission rate (∼ 278 g/mm2.24 h) were improved. The results of the antioxidant activity showed that this extract increased the antioxidant activity of NFs by about ∼ 60% in the highest concentration (10 wt%) and also inhibited the growth of pathogenic bacteria. In conclusion, the PLA/HPMC electrospun NFs with ratio of 80:20 containing 10% PPE can be a good candidate as the new active food packaging system.

This is a preview of subscription content, access via your institution.

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9

Data Availability

Not applicable.

References

  1. Abu-dalo, M., Jaradat, A., Albiss, B. A., & Al-rawashdeh, N. A. F. (2019). Green synthesis of TiO 2 NPs / pristine pomegranate peel extract nanocomposite and its antimicrobial activity for water disinfection. Journal of Environmental Chemical Engineering, 7(5), 103370. https://doi.org/10.1016/j.jece.2019.103370

    CAS  Article  Google Scholar 

  2. Aghdam, M. S., Luo, Z., Li, L., Jannatizadeh, A., Fard, J. R., & Pirzad, F. (2020). Melatonin treatment maintains nutraceutical properties of pomegranate fruits during cold storage. Food Chemistry, 303, 125385. https://doi.org/10.1016/j.foodchem.2019.125385

    CAS  Article  PubMed  Google Scholar 

  3. Ahmadian, S., Ghorbani, M., & Mahmoodzadeh, F. (2020). Silver sulfadiazine-loaded electrospun ethyl cellulose/polylactic acid/collagen nanofibrous mats with antibacterial properties for wound healing. International Journal of Biological Macromolecules, 162, 1555–1565. https://doi.org/10.1016/j.ijbiomac.2020.08.059

    CAS  Article  PubMed  Google Scholar 

  4. Akhtar, S., Ismail, T., Fraternale, D., & Sestili, P. (2015). Pomegranate peel and peel extracts : Chemistry and food features. FOOD CHEMISTRY, 174, 417–425. https://doi.org/10.1016/j.foodchem.2014.11.035

    CAS  Article  PubMed  Google Scholar 

  5. Alexandre, E. M. C., Silva, S., Santos, S. A. O., Silvestre, A. J. D., Duarte, M. F., Saraiva, J. A., & Pintado, M. (2019). Antimicrobial activity of pomegranate peel extracts performed by high pressure and enzymatic assisted extraction. Food Research International, 115(June 2018), 167–176. https://doi.org/10.1016/j.foodres.2018.08.044

  6. Altan, A., Aytac, Z., & Uyar, T. (2018). Carvacrol loaded electrospun fibrous films from zein and poly(lactic acid) for active food packaging. Food Hydrocolloids, 81, 48–59. https://doi.org/10.1016/j.foodhyd.2018.02.028

    CAS  Article  Google Scholar 

  7. Aman Mohammadi,  M., Ramezani, S., Hosseini, H., Mortazavian, A. M., Hosseini, S. M., Ghorbani, M. (2021). Electrospun antibacterial and antioxidant zein/polylactic acid/hydroxypropyl methylcellulose nanofibers as an active food packaging system. Food and Bioprocess Technology, 1–13. https://doi.org/10.1007/s11947-021-02654-7

  8. Amjadi, S., Almasi, H., Ghorbani, M., & Ramazani, S. (2020a). Preparation and characterization of TiO2NPs and betanin loaded zein/sodium alginate nanofibers. Food Packaging and Shelf Life, 24, 100504. https://doi.org/10.1016/j.fpsl.2020.100504

    Article  Google Scholar 

  9. Amjadi, S., Almasi, H., Ghorbani, M., & Ramazani, S. (2020b). Reinforced ZnONPs/ rosemary essential oil-incorporated zein electrospun nanofibers by κ-carrageenan. Carbohydrate Polymers, 232, 115800. https://doi.org/10.1016/j.carbpol.2019.115800

    CAS  Article  PubMed  Google Scholar 

  10. Amjadi, S., Emaminia, S., Nazari, M., Davudian, S. H., Roufegarinejad, L., & Hamishehkar, H. (2019). Application of reinforced ZnO nanoparticle-incorporated gelatin bionanocomposite film with chitosan nanofiber for packaging of chicken fillet and cheese as food models. Food and Bioprocess Technology, 12(7), 1205–1219. https://doi.org/10.1007/s11947-019-02286-y

    CAS  Article  Google Scholar 

  11. Araújo, J. M. S., de Siqueira, A. C. P., Blank, A. F., Narain, N., & de Aquino Santana, L. C. L. (2018). A cassava starch–chitosan edible coating enriched with Lippia sidoides Cham. Essential oil and pomegranate peel extract for preservation of Italian tomatoes (Lycopersicon esculentum Mill.) stored at room temperature. Food and Bioprocess Technology, 11(9), 1750–1760. https://doi.org/10.1007/s11947-018-2139-9

  12. Aydogdu, A., Yildiz, E., Ayhan, Z., Aydogdu, Y., Sumnu, G., & Sahin, S. (2019). Nanostructured poly(lactic acid)/soy protein/HPMC films by electrospinning for potential applications in food industry. European Polymer Journal, 112, 477–486. https://doi.org/10.1016/j.eurpolymj.2019.01.006

    CAS  Article  Google Scholar 

  13. Azarpazhooh, E., Sharayei, P., Zomorodi, S., & Ramaswamy, H. S. (2019). Physicochemical and phytochemical characterization and storage stability of freeze-dried encapsulated pomegranate peel anthocyanin and in vitro evaluation of its antioxidant activity. Food and Bioprocess Technology, 12(2), 199–210. https://doi.org/10.1007/s11947-018-2195-1

    CAS  Article  Google Scholar 

  14. Basch, C. Y., Jagus, R. J., & Flores, S. K. (2013). Physical and antimicrobial properties of tapioca starch-HPMC edible films incorporated with nisin and/or potassium sorbate. Food and Bioprocess Technology, 6(9), 2419–2428. https://doi.org/10.1007/s11947-012-0860-3

    CAS  Article  Google Scholar 

  15. Bilbao-sainz, C., Chiou, B., Valenzuela-medina, D., Du, W., Gregorski, K. S., Williams, T. G., et al. (2014). Solution blow spun poly ( lactic acid )/ hydroxypropyl methylcellulose nanofibers with antimicrobial properties. European Polymer Journal, 54, 1–10. https://doi.org/10.1016/j.eurpolymj.2014.02.004

    CAS  Article  Google Scholar 

  16. Chaves, F. M., Pavan, I. C. B., da Silva, L. G. S., de Freitas, L. B., Rostagno, M. A., Antunes, A. E. C., et al. (2020). Pomegranate juice and peel extracts are able to inhibit proliferation, migration and colony formation of prostate cancer cell lines and modulate the Akt/mTOR/S6K signaling pathway. Plant Foods for Human Nutrition, 75(1), 54–62. https://doi.org/10.1007/s11130-019-00776-0

    CAS  Article  PubMed  Google Scholar 

  17. Cui, H., Surendhiran, D., Li, C., & Lin, L. (2020). Biodegradable zein active film containing chitosan nanoparticle encapsulated with pomegranate peel extract for food packaging. Food Packaging and Shelf Life, 24, 100511. https://doi.org/10.1016/j.fpsl.2020.100511

    Article  Google Scholar 

  18. Dehghan, S. F., Golbabaei, F., Maddah, B., Latifi, M., Pezeshk, H., Hasanzadeh, M., & Akbar-Khanzadeh, F. (2016). Optimization of electrospinning parameters for polyacrylonitrile-MgO nanofibers applied in air filtration. Journal of the Air and Waste Management Association, 66(9), 912–921. https://doi.org/10.1080/10962247.2016.1162228

    CAS  Article  PubMed  Google Scholar 

  19. Deng, L., Li, Y., Feng, F., Wu, D., & Zhang, H. (2019). Encapsulation of allopurinol by glucose cross-linked gelatin/zein nanofibers: Characterization and release behavior. Food Hydrocolloids, 94, 574–584. https://doi.org/10.1016/j.foodhyd.2019.04.004

    CAS  Article  Google Scholar 

  20. Dharmalingam, K., & Anandalakshmi, R. (2019). Fabrication, characterization and drug loading efficiency of citric acid crosslinked NaCMC-HPMC hydrogel films for wound healing drug delivery applications. International Journal of Biological Macromolecules, 134, 815–829. https://doi.org/10.1016/j.ijbiomac.2019.05.027

    CAS  Article  PubMed  Google Scholar 

  21. Dongdong, L., Qingyang, Y., Jiang, L., & Luo, Z. (2016). Effects of nano-TiO2-LDPE packaging on postharvest quality and antioxidant capacity of strawberry (Fragaria ananassa Duch.) stored at refrigeration temperature. Journal of the Science of Food and Agriculture, 97, 1116–1123. https://doi.org/10.1002/jsfa.7837

    CAS  Article  Google Scholar 

  22. Duan, M., Yu, S., Sun, J., Jiang, H., Zhao, J., & Tong, C. (2021). Development and characterization of electrospun nanofibers based on pullulan / chitin nanofibers containing curcumin and anthocyanins for active-intelligent food packaging. International Journal of Biological Macromolecules, 187, 332–340. https://doi.org/10.1016/j.ijbiomac.2021.07.140

    CAS  Article  PubMed  Google Scholar 

  23. Farshi, P., Tabibiazar, M., Ghorbani, M., Mohammadifar, M., Amirkhiz, M. B., & Hamishehkar, H. (2019). Whey protein isolate-guar gum stabilized cumin seed oil nanoemulsion. Food Bioscience, 28, 49–56. https://doi.org/10.1016/j.fbio.2019.01.011

    CAS  Article  Google Scholar 

  24. Ghorbani, M., Hamishehkar, H., Arsalani, N., & Entezami, A. A. (2016). Surface decoration of magnetic nanoparticles with folate-conjugated poly(N-isopropylacrylamide-co-itaconic acid): A facial synthesis of dual-responsive nanocarrier for targeted delivery of doxorubicin. International Journal of Polymeric Materials and Polymeric Biomaterials, 65(13), 683–694. https://doi.org/10.1080/00914037.2016.1157800

    CAS  Article  Google Scholar 

  25. Ghorbani, M., Mahmoodzadeh, F., Yavari, L., & Nezhad-mokhtari, P. (2020a). Electrospun tetracycline hydrochloride loaded zein / gum tragacanth / poly lactic acid nanofibers for biomedical application. International Journal of Biological Macromolecules, 165, 1312–1322. https://doi.org/10.1016/j.ijbiomac.2020.09.225

    CAS  Article  PubMed  Google Scholar 

  26. Ghorbani, M., Nezhad-Mokhtari, P., & Ramazani, S. (2020b). Aloe vera-loaded nanofibrous scaffold based on zein/polycaprolactone/collagen for wound healing. International Journal of Biological Macromolecules, 153, 921–930. https://doi.org/10.1016/j.ijbiomac.2020.03.036

    CAS  Article  PubMed  Google Scholar 

  27. Ghorbani, M., Ramezani, S., & Rashidi, M. R. (2021). Fabrication of honey-loaded ethylcellulose/gum tragacanth nanofibers as an effective antibacterial wound dressing. Colloids and Surfaces a: Physicochemical and Engineering Aspects, 621, 126615. https://doi.org/10.1016/j.colsurfa.2021.126615

    CAS  Article  Google Scholar 

  28. González, E., Shepherd, L. M., Saunders, L., & Frey, M. W. (2016). Surface functional poly(lactic acid) electrospun nanofibers for biosensor applications. Materials, 9(1), 1–11. https://doi.org/10.3390/ma9010047

    CAS  Article  Google Scholar 

  29. Gullon, B., Pintado, M. E., Pérez-Álvarez, J. A., & Viuda-Martos, M. (2016). Assessment of polyphenolic profile and antibacterial activity of pomegranate peel (Punica granatum) flour obtained from co-product of juice extraction. Food Control, 59, 94–98. https://doi.org/10.1016/j.foodcont.2015.05.025

    CAS  Article  Google Scholar 

  30. Hanani, Z. A. N., Yee, F. C., & Nor-Khaizura, M. A. R. (2019). Effect of pomegranate (Punica granatum L.) peel powder on the antioxidant and antimicrobial properties of fish gelatin films as active packaging. Food Hydrocolloids, 89, 253–259. https://doi.org/10.1016/j.foodhyd.2018.10.007

    CAS  Article  Google Scholar 

  31. Ignatova, M., Manolova, N., Rashkov, I., & Markova, N. (2016). Quaternized chitosan/κ-carrageenan/caffeic acid–coated poly(3-hydroxybutyrate) fibrous materials: Preparation, antibacterial and antioxidant activity. International Journal of Pharmaceutics, 513(1–2), 528–537. https://doi.org/10.1016/j.ijpharm.2016.09.062

    CAS  Article  PubMed  Google Scholar 

  32. Kazemi, M., Karim, R., Mirhosseini, H., & Hamid, A. A. (2017). Processing of parboiled wheat noodles fortified with pulsed ultrasound pomegranate (Punica granatum L. var. Malas) peel extract. Food and Bioprocess Technology, 10(2), 379–393. https://doi.org/10.1007/s11947-016-1825-8

  33. Li, D., Zhang, X., Li, L., Aghdam, M. S., Wei, X., Liu, J., et al. (2019). Elevated CO2 delayed the chlorophyll degradation and anthocyanin accumulation in postharvest strawberry fruit. Food Chemistry, 285, 163–170. https://doi.org/10.1016/j.foodchem.2019.01.150

    CAS  Article  PubMed  Google Scholar 

  34. Li, M., Yu, H., Xie, Y., Guo, Y., Cheng, Y., Qian, H., & Yao, W. (2021). Fabrication of eugenol loaded gelatin nanofibers by electrospinning technique as active packaging material. Lwt, 139, 110800. https://doi.org/10.1016/j.lwt.2020.110800

    CAS  Article  Google Scholar 

  35. Liu, Y., Wang, D., Sun, Z., Liu, F., Du, L., & Wang, D. (2021). Preparation and characterization of gelatin/chitosan/3-phenylacetic acid food-packaging nanofiber antibacterial films by electrospinning. International Journal of Biological Macromolecules, 169, 161–170. https://doi.org/10.1016/j.ijbiomac.2020.12.046

    CAS  Article  PubMed  Google Scholar 

  36. Liu, Y., Deng, L., Zhang, C., Feng, F., & Zhang, H. (2018). Tunable physical properties of ethylcellulose/gelatin composite nanofibers by electrospinning. Journal of Agricultural and Food Chemistry, 66(8), 1907–1915. https://doi.org/10.1021/acs.jafc.7b06038

    CAS  Article  PubMed  Google Scholar 

  37. Luo, X., Guo, Z., He, P., Chen, T., Li, L., Ding, S., & Li, H. (2018). Study on structure, mechanical property and cell cytocompatibility of electrospun collagen nanofibers crosslinked by common agents. International Journal of Biological Macromolecules, 113, 476–486. https://doi.org/10.1016/j.ijbiomac.2018.01.179

    CAS  Article  PubMed  Google Scholar 

  38. Min, T., Sun, X., Yuan, Z., Zhou, L., Jiao, X., Zha, J., et al. (2021). Novel antimicrobial packaging film based on porous poly(lactic acid) nanofiber and polymeric coating for humidity-controlled release of thyme essential oil. Lwt, 135, 110034. https://doi.org/10.1016/j.lwt.2020.110034

    CAS  Article  Google Scholar 

  39. Mir, S. A., Shah, M. A., Dar, B. N., Wani, A. A., Ganai, S. A., & Nishad, J. (2017). Supercritical impregnation of active components into polymers for food packaging applications. Food and Bioprocess Technology, 10(9), 1749–1754. https://doi.org/10.1007/s11947-017-1937-9

    CAS  Article  Google Scholar 

  40. Motelica, L., Ficai, D., Ficai, A., Oprea, O. C., Kaya, D. A., & Andronescu, E. (2020). Biodegradable antimicrobial food packaging: Trends and perspectives. Foods, 9(10), 1–36. https://doi.org/10.3390/foods9101438

    CAS  Article  Google Scholar 

  41. Nair, M. S., Saxena, A., & Kaur, C. (2018). Characterization and antifungal activity of pomegranate peel extract and its use in polysaccharide-based edible coatings to extend the shelf-life of capsicum (Capsicum annuum L.). Food and Bioprocess Technology, 11(7), 1317–1327. https://doi.org/10.1007/s11947-018-2101-x

  42. Nur Hanani, Z. A., Aelma Husna, A. B., Nurul Syahida, S., Nor Khaizura, M. A. B., & Jamilah, B. (2018). Effect of different fruit peels on the functional properties of gelatin/polyethylene bilayer films for active packaging. Food Packaging and Shelf Life, 18, 201–211. https://doi.org/10.1016/j.fpsl.2018.11.004

    Article  Google Scholar 

  43. Panichayupakaranant, P., Tewtrakul, S., & Yuenyongsawad, S. (2010). Antibacterial, anti-inflammatory and anti-allergic activities of standardised pomegranate rind extract. Food Chemistry, 123(2), 400–403. https://doi.org/10.1016/j.foodchem.2010.04.054

    CAS  Article  Google Scholar 

  44. Perone, N., Torrieri, E., Cavella, S., & Masi, P. (2014). Effect of rosemary oil and HPMC concentrations on film structure and properties. Food and Bioprocess Technology, 7(2), 605–609. https://doi.org/10.1007/s11947-012-1044-x

    CAS  Article  Google Scholar 

  45. Pirsa, S., Sani, I. K., Pirouzifard, M. K., & Erfani, A. (2020). Extract to detect cream cheeses spoilage Smart film based on chitosan / Melissa officinalis essences / pomegranate peel extract to detect cream cheeses spoilage Sajad Pirsa, Iraj Karimi Sani, Mir Khalil Pirouzifard & Aref Erfani. Food Additives & Contaminants: Part A, 00(00), 1–15. https://doi.org/10.1080/19440049.2020.1716079

    CAS  Article  Google Scholar 

  46. Ren, Y., Huang, L., Wang, Y., Mei, L., Fan, R., He, M., et al. (2020). Stereocomplexed electrospun nanofibers containing poly (lactic acid) modified quaternized chitosan for wound healing. Carbohydrate Polymers, 247(July), 116754. https://doi.org/10.1016/j.carbpol.2020.116754

    CAS  Article  PubMed  Google Scholar 

  47. Saberi, B., Vuong, Q. V., Chockchaisawasdee, S., Golding, J. B., Scarlett, C. J., & Stathopoulos, C. E. (2017). Physical, barrier, and antioxidant properties of pea starch-guar gum biocomposite edible films by incorporation of natural plant extracts. Food and Bioprocess Technology, 10(12), 2240–2250. https://doi.org/10.1007/s11947-017-1995-z

    CAS  Article  Google Scholar 

  48. Shao, S., Li, L., Yang, G., Li, J., Luo, C., Gong, T., & Zhou, S. (2011). Controlled green tea polyphenols release from electrospun PCL/MWCNTs composite nanofibers. International Journal of Pharmaceutics, 421(2), 310–320. https://doi.org/10.1016/j.ijpharm.2011.09.033

    CAS  Article  PubMed  Google Scholar 

  49. Song, B., Li, J., & Li, J. (2016). Pomegranate peel extract polyphenols induced apoptosis in human hepatoma cells by mitochondrial pathway. Food and Chemical Toxicology, 93, 158–166. https://doi.org/10.1016/j.fct.2016.04.020

    CAS  Article  PubMed  Google Scholar 

  50. Surendhiran, D., Li, C., Cui, H., & Lin, L. (2020). Fabrication of high stability active nanofibers encapsulated with pomegranate peel extract using chitosan / PEO for meat preservation. Food Packaging and Shelf Life, 23(March 2019), 100439. https://doi.org/10.1016/j.fpsl.2019.100439

  51. Tavassoli-kafrani, E., Amir, S., Goli, H., & Fathi, M. (2018). Encapsulation of orange essential oil using cross-linked electrospun gelatin nanofibers, 427–434.

  52. Van Hai, L., Zhai, L., Kim, H. C., Panicker, P. S., Pham, D. H., & Kim, J. (2020). Chitosan nanofiber and cellulose nanofiber blended composite applicable for active food packaging. Nanomaterials, 10(9), 1–14. https://doi.org/10.3390/nano10091752

    CAS  Article  Google Scholar 

  53. Wang, M., Li, D., Li, J., Li, S., Chen, Z., Yu, D., et al. (2020). Electrospun Janus zein – PVP nanofibers provide a two-stage controlled release of poorly water-soluble drugs. Materials & Design, 196, 109075. https://doi.org/10.1016/j.matdes.2020.109075

    CAS  Article  Google Scholar 

  54. Xu, Y., Charles, M. T., Luo, Z., Mimee, B., Tong, Z., Véronneau, P. Y., et al. (2019). Ultraviolet-C priming of strawberry leaves against subsequent Mycosphaerella fragariae infection involves the action of reactive oxygen species, plant hormones, and terpenes. Plant Cell and Environment, 42(3), 815–831. https://doi.org/10.1111/pce.13491

    CAS  Article  Google Scholar 

  55. Yavari, L., & Ghorbani, M. (2021). International Journal of Biological Macromolecules Injectable Chitosan-Quince Seed Gum Hydrogels Encapsulated with Curcumin Loaded-Halloysite Nanotubes Designed for Tissue Engineering Application, 177, 485–494. https://doi.org/10.1016/j.ijbiomac.2021.02.113

    CAS  Article  Google Scholar 

  56. Yavari, L., Ghorbani, M., Tabibiazar, M., Mohammadi, M., & Pezeshki, A. (2021a). International Journal of Biological Macromolecules Advanced Properties of Gelatin Film by Incorporating Modified Kappa-Carrageenan and Zein Nanoparticles for Active Food Packaging, 183, 753–759. https://doi.org/10.1016/j.ijbiomac.2021.04.163

    CAS  Article  Google Scholar 

  57. Yavari, L., Tabibiazar, M., Ghorbani, M., & Jahanban-esfahlan, A. (2021b). International Journal of Biological Macromolecules Fabrication and characterization of novel antibacterial chitosan / dialdehyde guar gum hydrogels containing pomegranate peel extract for active food packaging application. International Journal of Biological Macromolecules, 187(July), 179–188. https://doi.org/10.1016/j.ijbiomac.2021.07.126

    CAS  Article  Google Scholar 

  58. Yavari Maroufi, L., Ghorbani, M., Mohammadi, M., & Pezeshki, A. (2021c). Improvement of the physico-mechanical properties of antibacterial electrospun poly lactic acid nanofibers by incorporation of guar gum and thyme essential oil. Colloids and Surfaces a: Physicochemical and Engineering Aspects, 622(March), 126659. https://doi.org/10.1016/j.colsurfa.2021.126659

    CAS  Article  Google Scholar 

  59. Yavari Maroufi, L., Ghorbani, M., & Tabibiazar, M. (2020). A gelatin-based film reinforced by covalent interaction with oxidized guar gum containing green tea extract as an active food packaging system. Food and Bioprocess Technology, 13(9), 1633–1644. https://doi.org/10.1007/s11947-020-02509-7

    CAS  Article  Google Scholar 

  60. Zadeh, K. M., Luyt, A. S., Zarif, L., Augustine, R., Hasan, A., & Messori, M., et al. (2019). Electrospun polylactic acid / date palm polyphenol extract nanofibres for tissue engineering applications, 141–151.

  61. Zhang, R., Lan, W., Ji, T., Sameen, D. E., Ahmed, S., Qin, W., & Liu, Y. (2021). Development of polylactic acid/ZnO composite membranes prepared by ultrasonication and electrospinning for food packaging. Lwt, 135(August 2020), 110072. https://doi.org/10.1016/j.lwt.2020.110072

  62. Zhang, W., Li, X., & Jiang, W. (2020). International Journal of Biological Macromolecules Development of antioxidant chitosan film with banana peels extract and its application as coating in maintaining the storage quality of apple. International Journal of Biological Macromolecules, 154, 1205–1214. https://doi.org/10.1016/j.ijbiomac.2019.10.275

    CAS  Article  PubMed  Google Scholar 

  63. Zou, Y., Zhang, C., Wang, P., Zhang, Y., & Zhang, H. (2020). Electrospun chitosan/polycaprolactone nanofibers containing chlorogenic acid-loaded halloysite nanotube for active food packaging. Carbohydrate Polymers, 247(June), 116711. https://doi.org/10.1016/j.carbpol.2020.116711

    CAS  Article  PubMed  Google Scholar 

Download references

Funding

This research was supported by the Nutrition Research Center; Tabriz University of Medical Sciences (Grant Number: 67774).

Author information

Affiliations

Authors

Corresponding author

Correspondence to Marjan Ghorbani.

Ethics declarations

Conflict of Interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bodbodak, S., Shahabi, N., Mohammadi, M. et al. Development of a Novel Antimicrobial Electrospun Nanofiber Based on Polylactic Acid/Hydroxypropyl Methylcellulose Containing Pomegranate Peel Extract for Active Food Packaging. Food Bioprocess Technol (2021). https://doi.org/10.1007/s11947-021-02722-y

Download citation

Keywords

  • Electrospinning nanofiber
  • Food packaging
  • Polylactic acid
  • Hydroxypropyl methylcellulose
  • Pomegranate peel extract