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Food and Bioprocess Technology

, Volume 8, Issue 4, pp 709–728 | Cite as

Double Emulsions: Emerging Delivery System for Plant Bioactives

  • Heena Lamba
  • Kumar Sathish
  • Latha Sabikhi
Review Paper

Abstract

Bioactives have shown excellent protective effect against chronic diseases such as cancer, cardiovascular diseases and metabolic disorders. However, many of the bioactives like anthocyanins, carotenoids, flavonoids, vitamins and essential fatty acids are sensitive to surrounding environment stresses like pH, ionic strength, light, temperature, oxygen and gastro-intestinal (GI) conditions during transit. Hence, the functionality diminishes upon exposure to such unfriendly environment and leads to reduction in bioavailability. Double emulsions are designed to provide protection to bioactives in the innermost compartment through encapsulation and prevent loss of functionality in food matrix as well as during the GI transit. This article reviews the work done on double emulsion for food applications, covering various aspects of double emulsion like its matrix, constituents (aqueous phase, oil phase, emulsifiers, and other additives) and properties (viscosity, particle size, electrical conductivity and zeta potential). In addition to the stability of double emulsion, various means to express and modern techniques to measure it, the review also elucidates the role of newer emulsifiers and additives in improving the stability of double emulsion. The developments in target delivery of bioactives through double emulsion are highlighted. In vitro and in vivo studies proved target delivery of bioactives through double emulsion; however, confirmation through human trial is still pending.

Keywords

Emulsifier Particle size Nano emulsion Target delivery Zeta potential 

References

  1. Akhtar, M., & Dickinson, E. (2003). Emulsifying properties of whey protein-dextran conjugates at low pH and different salt concentrations. Colloids and Surfaces B: Biointerfaces, 31(1–4), 125–132.Google Scholar
  2. Appelqvist, I. A. M., Golding, M., Vreeker, R., & Zuidam, N. J. (2007). Emulsions as delivery systems in foods. In J. M. Lakkis (Ed.), Encapsulation and controlled release technologies in food systems (pp. 41–81). Oxford: Blackwell Publishing.Google Scholar
  3. Aronson, M. P., & Petko, M. F. (1993). Highly concentrated water-in-oil emulsions: influence of electrolyte on their properties and stability. Journal of Colloid and Interface Science, 159(1), 134–149.Google Scholar
  4. Aserin, A. (Ed.). (2008). Multiple emulsions: technology and applications. Hoboken, New Jersey: Wiley.Google Scholar
  5. Benichou, A., Aserin, A., & Garti, N. (2004). Double emulsions stabilized with hybrids of natural polymers for entrapment and slow release of active matters. Advances in Colloid and Interface Science, 108–109, 29–41.Google Scholar
  6. Benichou, A., Aserin, A., & Garti, N. (2007). W/O/W double emulsions stabilized with WPI-polysaccharide complexes. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 294(1–3), 20–32.Google Scholar
  7. Benna-Zayani, M., Kbir-Ariguib, N., Trabelsi-Ayadi, N., & Grossiord, J. L. (2008). Stabilisation of W/O/W double emulsion by polysaccharides as weak gels. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 316(1–3), 46–54.Google Scholar
  8. Blanco-Prieto, M. J., Fattal, E., Gulik, A., Dedieu, J. C., Roques, B. P., & Couvreur, P. (1997). Characterization and morphological analysis of a cholecystokinin derivative peptide-loaded poly(lactide-coglycolide) microspheres prepared by a water-in-oil-in-water emulsion solvent evaporation method. Journal of Controlled Release, 43(1), 81–87.Google Scholar
  9. Bozkir, A., & Hayta, G. (2004). Preparation and evaluation of multiple emulsions water-in-oil-in-water (w/o/w) as delivery system for influenza virus antigens. Journal of Drug Targeting, 12(3), 157–164.Google Scholar
  10. Cameron, N. R. (2005). High internal phase emulsion templating as a route to well-defined porous polymers. Polymer, 46(5), 1439–1449.Google Scholar
  11. Chanamai, R., & McClements, D. J. (2000). Creaming stability of flocculated monodisperse oil-in-water emulsions. Journal of Colloid and Interface Science, 225(1), 214–218.Google Scholar
  12. Charcosset, C. (2009). Preparation of emulsions and particles by membrane emulsification for the food processing industry. Journal of Food Engineering, 92(3), 241–249.Google Scholar
  13. Chen, R., Dong, P. F., Xu, J. H., Wang, Y. D., & Luo, G. S. (2012). Controllable microfluidic production of gas-in-oil-in-water emulsions for hollow microspheres with thin polymer shells. Lab on a Chip, 12(20), 3858–3860.Google Scholar
  14. Cho, Y. H., & Park, J. (2003). Evaluation of process parameters in the O/W/O multiple emulsion method for flavor encapsulation. Journal of Food Science, 68(2), 534–538.Google Scholar
  15. Choi, M. J., Briançon, S., Bazile, D., Royere, A., Min, S. G., & Fessi, H. (2007). Effect of cryoprotectant and freeze-drying process on the stability of W/O/W emulsions. Drying Technology, 25(5), 809–819.Google Scholar
  16. Cournarie, F., Savelli, M. P., Rosilio, V., Bretez, F., Vauthier, C., Grossiord, J. L., et al. (2004). Insulin-loaded W/O/W multiple emulsions: comparison of the performances of systems prepared with medium-chain-triglycerides and fish oil. European Journal of Pharmaceutics and Biopharmaceutics, 58(3), 477–482.Google Scholar
  17. Couvreur, P., Blanco-Prieto, M. J., Puisieux, F., Roques, B., & Fattal, E. (1997). Multiple emulsion technology for the design of microspheres containing peptide and oligopeptides. Advanced Drug Delivery Reviews, 28(1), 85–96.Google Scholar
  18. Danny, A., & Buttriss, J. (2005). Plant foods and health focus on plant bioactives. Norwich, UK: British Nutrition Foundation/EuroFIR.Google Scholar
  19. Dauchet, L., Amouyel, P., Hercberg, S., & Dallongeville, J. (2006). Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies. Journal of Nutrition, 136(10), 2588–2593.Google Scholar
  20. Davis, S. S., & Walker, I. M. (1983). Measurement of the yield of multiple emulsion droplets by a fluorescent tracer technique. International Journal of Pharmaceutics, 17(2–3), 203–213.Google Scholar
  21. Davis, S. S., & Walker, I. M. (1987). Multiple emulsions as targetable delivery systems. Methods in Enzymology, 149, 51–64.Google Scholar
  22. Denny, S. I., Thompson, R. L., & Margetts, B. M. (2003). Dietary factors in the pathogenesis of asthma and chronic obstructive pulmonary disease. Current Allergy and Asthma Reports, 3(2), 130–136.Google Scholar
  23. Dickinson, E. (1993). Protein-polysaccharide interactions in food colloids. In E. Dickinson & P. Walstra (Eds.), Food colloids and polymers: stability and mechanical properties (pp. 77–93). London: The Royal Society of Chemistry.Google Scholar
  24. Dickinson, E. (2011). Double emulsions stabilized by food biopolymers. Food Biophysics, 6(1), 1–11.Google Scholar
  25. Dickinson, E., & Euston, S. R. (1991). Stability of food emulsions containing both protein and polysaccharide. In E. Dickinson (Ed.), Food polymers, gels and colloids (pp. 132–146). London: The Royal Society of Chemistry.Google Scholar
  26. Dickinson, E., & McClements, D. J. (1996). Water-in-oil-in-water multiple emulsions. In E. Dickinson & D. J. McClements (Eds.), Advances in food colloids (pp. 280–300). Cambridge: Blackie Academic and Professional.Google Scholar
  27. Dickinson, E., Evison, J., & Owusu, R. K. (1991). Preparation of fine protein-stabilized water-in-oil-in-water emulsions. Food Hydrocolloids, 5(5), 481–485.Google Scholar
  28. Dickinson, E., Evison, J., Owusu, R. K., & Williams, A. (1994). Protein stabilized water-in-oil-in-water emulsions. In G. O. Phillips, P. A. Williams, & D. J. Wedlock (Eds.), Gums and stabilisers for the food industry (pp. 91–101). New York: Oxford University Press.Google Scholar
  29. Dickinson, E., Evison, J., Owusu, R. K., & Zhu, Q. (1993). Studies of water-in-oil-in-water (w/o/w) multiple emulsions: stabilization and controlled nutrient release. In E. Dickinson & P. Walstra (Eds.), Food colloids and polymers: stability and mechanical properties (pp. 243–249). London: Royal Society of Chemistry.Google Scholar
  30. Dunlap, C. A., & Cote, G. L. (2005). β-Lactoglobulin-dextran conjugates: effect of polysaccharide size on emulsion stability. Journal of Agricultural and Food Chemistry, 53(2), 419–423.Google Scholar
  31. Edris, A., & Bergnstahl, B. (2001). Encapsulation of orange oil in a spray dried double emulsion. Nahrung Food, 45(2), 133–137.Google Scholar
  32. Einhorn-Stoll, U., Ulbrich, M., Sever, S., & Kunzek, H. (2005). Formation of milk protein-pectin conjugates with improved emulsifying properties by controlled dry heating. Food Hydrocolloids, 19(2), 329–340.Google Scholar
  33. Evison, J., Dickinson, E., Owusu, R., & Williams, A. (1995). Formulation and properties of protein-stabilized water-in-oil-in-water multiple emulsions. In E. Dickinson & D. Lorient (Eds.), Food macromolecules and colloids (pp. 235–243). London: Special Publication-Royal Society of Chemistry.Google Scholar
  34. Farahmand, S., Tajerzadeh, H., & Farboud, E. S. (2006). Formulation and evaluation of a vitamin C multiple emulsion. Pharmaceutical Development and Technology, 11(2), 255–261.Google Scholar
  35. Fechner, A., Knoth, A., Scherze, I., & Muschiolik, G. (2007). Stability and release properties of double-emulsions stabilised by caseinate-dextran conjugates. Food Hydrocolloids, 21(5), 943–952.Google Scholar
  36. Florence, A. T., & Whitehill, D. (1981). Some features of breakdown in water-in-oil-in-water multiple emulsions. Journal of Colloid and Interface Science, 79(1), 243–256.Google Scholar
  37. Frank, K., Köhler, K., & Schuchmann, H. P. (2011). Formulation of labile hydrophilic ingredients in multiple emulsions: influence of the formulation's composition on the emulsion's stability and on the stability of entrapped bioactives. Journal of Dispersion Science and Technology, 32(12), 1753–1758.Google Scholar
  38. Frank, K., Walz, E., Graf, V., Greiner, R., Kohler, K., & Schuchmann, H. P. (2012). Stability of anthocyanin-rich w/o/w-emulsions designed for intestinal release in gastrointestinal environment. Journal of Food Science, 77(12), N51–N58.Google Scholar
  39. Gallarate, M., Carlotti, M. E., Trotta, M., & Bovo, S. (1999). On the stability of ascorbic acid in emulsified systems for topical and cosmetic use. International Journal of Pharmaceutics, 188(2), 233–241.Google Scholar
  40. Garti, N. (1997). Double emulsions—scope, limitations and new achievements. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 123–124, 233–246.Google Scholar
  41. Garti, N., & Benichou, A. (2001). Double emulsions for controlled release applications progress and trends. In J. Sjoblom (Ed.), Encyclopedic handbook of emulsion technology (pp. 377–407). New York: Marcel Dekker.Google Scholar
  42. Garti, N., Aserin, A., Tiunova, I., & Binyamin, H. (1999). Double emulsions of water-in-oil-in-water stabilized by α-form fat microcrystals. Part 1: selection of emulsifiers and fat microcrystalline particles. Journal of the American Oil Chemists Society, 76(3), 383–389.Google Scholar
  43. Garti, N., Binyamin, H., & Aserin, A. (1998). Stabilization of water-in-oil emulsions by submicrocrystalline alpha-form fat particles. Journal of the American Oil Chemists Society, 75(12), 1825–1831.Google Scholar
  44. Giroux, H. J., Constantineau, S., Fustier, P., Champagne, C. P., St-Gelais, D., Lacroix, M., et al. (2013). Cheese fortification using water-in-oil-in-water double emulsions as carrier for water soluble nutrients. International Dairy Journal, 29(2), 107–114.Google Scholar
  45. Gu, Y. S., Decker, E. A., & McClements, D. J. (2006). Irreversible thermal denaturation of betalactoglobulin retards adsorption of carrageenan onto beta-lactoglobulin-coated droplets. Langmuir, 22(18), 7480–7486.Google Scholar
  46. Harnsilawat, T., Pongsawatmanit, R., & McClements, D. J. (2006). Stabilization of model beverage cloud emulsions using protein-polysaccharide electrostatic complexes formed at the oil-water interface. Journal of Agricultural and Food Chemistry, 54(15), 5540–5547.Google Scholar
  47. Hearn, T. L., Olsen, M., & Hunter, R. L. (1996). Multiple emulsions oral vaccine vehicles for inducing immunity or tolerance. Annals of the New York Academy of Sciences, 778, 388–389.Google Scholar
  48. Hino, T., Shimabayashi, S., Tanaka, M., Nakano, M., & Okochi, H. (2001). Improvement of encapsulation efficiency of water-in-oil-in-water emulsion with hypertonic inner aqueous phase. Journal of Microencapsulation, 18(1), 19–28.Google Scholar
  49. Hoensch, H. P., & Kirch, W. (2005). Potential role of flavonoids in the prevention of intestinal neoplasia: a review of their mode of action and their clinical perspectives. International Journal of Gastrointestinal Cancer, 35(3), 187–195.Google Scholar
  50. Hughes, E., Acquistapace, S., Gunes, D. Z., Atkins, T., Homewood, P. & Gray, R. (2012). Double encapsulated emulsion generation using a novel dual chip design. Retrieve from http://www.dolomite-microfluidics.com/images/stories/PDFs/application_notes/Double_encapsulated_emulsion_generation_using_a_novel_dual_chip_design.pdf. Accessed 19 May 2014.
  51. Hung, H. C., Joshipura, K. J., Jiang, R., Hu, F. B., Hunter, D., Smith-Warner, S. A., et al. (2004). Fruit and vegetable intake and risk of major chronic disease. Journal of the National Cancer Institute, 96(21), 1577–1584.Google Scholar
  52. ICI Americas Inc. (1980). The HLB system – a time saving guide to emulsifier selection. Retrieve from http://www.firp.ula.ve/archivos/historicos/76_Book_HLB_ICI.pdf. Accessed 15 March 2014.
  53. IFST. (2014). Nanotechnology. Institute of food, science and technology, London. Available on: http://www.ifst.org/print/125. Accessed 21 May 2014.
  54. Jahaniaval, F., Kakuda, Y., & Abraham, V. (2003). Characterization of a double emulsion system (oil-in-water-in-oil emulsion) with low solid fats: microstructure. Journal of the American Oil Chemists Society, 80(1), 25–31.Google Scholar
  55. Jiao, J., & Burgess, D. J. (2003). Rheology and stability of water-in-oil-in-water multiple emulsions containing Span 83 and Tween 80. American Association of Pharmaceutical Scientists, 5(1), 62–73.Google Scholar
  56. Jimenez-Alvarado, R., Beristain, C. I., Medina-Torres, L., Roman-Guerrero, A., & Vernon-Carter, E. J. (2009). Ferrous bisglycinate content and release in w1/o/w2 multiple emulsions stabilized by protein-polysaccharide complexes. Food Hydrocolloids, 23(8), 2425–2433.Google Scholar
  57. Joshipura, K. J., Ascherio, A., & Manson, J. E. (1999). Fruit and vegetable intake in relation to risk of ischemic stroke. Journal of the American Medical Association, 282(13), 1233–1239.Google Scholar
  58. Joshipura, K. J., Hu, F. B., Manson, J. E., Stampfer, M. J., Rimm, E. B., Speizer, F. E., et al. (2001). The effect of fruit and vegetable intake on risk for coronary heart disease. Annals of Internal Medicine, 134(12), 1106–1114.Google Scholar
  59. Kaimainen, M., Marze, S., Jarvenpaa, E., Anton, M., & Huopalahti, R. (2014). Encapsulation of betalain into w/o/w double emulsion and release during in vitro intestinal lipid digestion. Lebensmittel-Wissenschaft und Technologie - Food Science and Technology. doi: 10.1016/j.lwt.2014.10.016.Google Scholar
  60. Kanouni, M., Rosano, H. L., & Naouli, N. (2002). Preparation of a stable double emulsion (w1/o/w2): role of the interfacial films on the stability of the system. Advances in Colloid and Interface Science, 99(3), 229–254.Google Scholar
  61. Kato, A. (1996). Functional protein-polysaccharide conjugates. Comments on Agriculture and Food Chemistry, 3, 139–153.Google Scholar
  62. Kato, A., Sasaki, Y., Furuta, R., & Kobayashi, K. (1990). Functional protein-polysaccharide conjugate prepared by controlled dry-heating of ovalbumin-dextran mixtures. Agricultural and Biological Chemistry, 54(1), 107–112.Google Scholar
  63. Kaufman, S. F. M., & Palzer, S. (2011). Food structure engineering for nutrition, health and wellness. Procedia Food Science, 1, 1479–1486.Google Scholar
  64. Key, T. J., Allen, N., Appleby, P., Overvad, K., Tjønneland, A., Miller, A., et al. (2004a). Fruits and vegetables and prostate cancer: no association among 1104 cases in a prospective study of 130544 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). International Journal of Cancer, 109(1), 119–124.Google Scholar
  65. Key, T. J., Schatzkin, A., Willett, W. C., Allen, N. E., Spencer, E. A., & Travis, R. C. (2004b). Diet, nutrition and the prevention of cancer. Public Health Nutrition, 7(1a), 187–200.Google Scholar
  66. Khaw, K. T., Bingham, S., Welch, A., Luben, R., Wareham, N., & Oakes, S. (2001). Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study in European Prospective Investigation into Cancer and Nutrition. The Lancet, 357(9257), 657–663.Google Scholar
  67. Kim, H. J., Decker, E. A., & McClements, D. J. (2006). Preparation of multiple emulsions based on thermodynamic incompatibility of heat-denatured whey protein and pectin solutions. Food Hydrocolloids, 20(5), 586–595.Google Scholar
  68. Knoth, A., Scherze, I., & Muschiolik, G. (2005). Stability of water-in-oil emulsions containing phosphatidylcholine depleted lecithin. Food Hydrocolloids, 19(3), 635–640.Google Scholar
  69. Kothawade, P. D., Gangurde, H. H., Surawase, R. K., Wagh, M. A., & Tamizharasi, S. (2011). Conventional and novel approaches for colon specific drug delivery: a review. e -Journal of Science and Technology (e-JST), 6(4), 33–56.Google Scholar
  70. Kralovec, J. A., Zhang, S., Zhang, W., & Barrow, C. J. (2012). A review of the progress in enzymatic concentration and microencapsulation of omega-3 rich oil from fish and microbial sources. Food Chemistry, 131(2), 639–644.Google Scholar
  71. Kumar, A. D. (2011). Masters in Technology thesis in Dairy Technology submitted to National Dairy Research Institute (Deemed University). Karnal, Haryana: India. Evaluation of selected matrix material for developing emulsion based delivery system for Pueraria tuberose/Vidarikand extract.Google Scholar
  72. Kumar, R., Kumar, M. S., & Mahadevan, N. (2012). Multiple emulsions: a review. International Journal of Recent Advances in Pharmaceutical Research, 2(1), 9–19.Google Scholar
  73. Lawson, & Braud, L. (2003). Water-in-oil-in-water double emulsions: targeted drug delivery under investigation. (Resource: engineering and technology for a sustainable world). Niles, Michigan: American society of agricultural and biological engineer.Google Scholar
  74. Lesmes, U., & McClements, D. J. (2009). Structure-function relationships to guide rational design and fabrication of particulate food delivery systems. Trends in Food Science and Technology, 20(10), 448–457.Google Scholar
  75. Li, B., Jiang, Y., Liu, F., Chai, Z., Li, Y., Li, Y., et al. (2012). Synergistic effects of whey protein-polysaccharide complexes on the controlled release of lipid soluble and water soluble vitamins in w1/o/w2 double emulsion systems. International Journal of Food Science and Technology, 47(2), 248–254.Google Scholar
  76. Liu, R., Huang, S., Wan, Y., Ma, G., & Su, Z. (2006). Preparation of insulin-loaded PLA/PLGA microcapsules by a novel membrane emulsification method and its release in vitro. Colloids and Surfaces B: Biointerfaces, 51(1), 30–38.Google Scholar
  77. Lutz, R., & Garti, N. (2006). Double emulsions. In P. Somasundaran (Ed.), Encyclopedia of surface and colloids science (pp. 1816–1845). London: Taylor and Francis.Google Scholar
  78. Lutz, R., Aserin, A., Wicker, L., & Garti, N. (2009). Release of electrolytes from W/O/W double emulsions stabilized by a soluble complex of modified pectin and whey protein isolate. Colloids and Surfaces B: Biointerfaces, 74(1), 178–185.Google Scholar
  79. Malvern Instruments. (2011). Zeta potentail - An introduction in 30 minutes. Zetasizer nano series technical note.  Retrieve from http://www3.nd.edu/~rroeder/ame60647/slides/zeta.pdf. Accessed 5 November 2014.
  80. Malvern Instruments. (2012). A Basic Guide to Particle Characterazation. Retrieve from http://golik.co.il/Data/ABasicGuidtoParticleCharacterization(2)_1962085150.pdf. Accessed 05 April 2014.
  81. Mark, D., Von Stetten, F., & Zengerle, R. (2012). Microfluidic apps for off-the-shelf instruments. Lab on a Chip, 12(14), 2464–2468.Google Scholar
  82. Matsumoto, S. (1983). Development of w/o/w type dispersion during phase inversion of concentrated w/o emulsion. Journal of Colloid and Interface Science, 94(2), 362–368.Google Scholar
  83. Matsumoto, S., Inove, T., Kohda, M., & Ohta, T. (1980). An attempt to estimate stability of the oil layer in w/o/w emulsions by means of viscometry. Journal of Colloid and Interface Science, 77(2), 564–565.Google Scholar
  84. Matsumoto, S., Koh, Y., & Michiura, A. (1985). Preparation of w/o/w emulsions in an edible form on the basis of phase inversion technique. Journal of Dispersion Science and Technology, 6(5), 507–520.Google Scholar
  85. McClements, D. J. (2005). Food emulsions: principles, practices and techniques (2nd ed.). Boca Raton, Florida: CRC Press.Google Scholar
  86. McClements, D. J., & Rao, J. (2011). Food-grade nanoemulsions: formulation, fabrication, properties, performance, biological fate, and potential toxicity. Critical Reviews in Food Science and Nutrition, 51(4), 285–330.Google Scholar
  87. Mezzenga, R., Folmer, B., & Hughes, E. (2004). Design of double emulsions by osmotic pressure tailoring. Langmuir, 20(9), 3574–3582.Google Scholar
  88. Mishra, S., Mann, B., & Joshi, V. K. (2001). Functional improvement of whey protein concentrate on interaction with pectin. Food Hydrocolloids, 15(1), 9–15.Google Scholar
  89. Mohanraj, V. J., & Chen, Y. (2006). Nanoparticles: a review. Tropical Journal of Pharmaceutical Research, 5(1), 561–573.Google Scholar
  90. Morais, J. M., Santos, O. D. H., & Friberg, S. E. (2010). Some fundamentals of the one-step formation of double emulsions. Journal of Dispersion Science and Technology, 31(8), 1019–1026.Google Scholar
  91. Morris, G., Sims, I. M., Robertson, A. J., & Furneaux, R. H. (2004). Investigation into the physical and chemical properties of sodium caseinate-maltodextrin glyco-conjugates. Food Hydrocolloids, 18(6), 1007–1014.Google Scholar
  92. Muschiolik, G., Scherze, I., Preissler, P., Weiss, J., Knoth, A., & Fechner, A. (2006). Multiple emulsions—preparation and stability. 13th World Congress of Food Science and Technology, IUFoST. doi: 10.1051/IUFoST:20060043.Google Scholar
  93. Muschiolik, G., Weiss, J., & Scherze, I. (2004). Microgel as carrier. Baking + Sweets, 4(2), 20.Google Scholar
  94. Nanocomposix. (2012). Guidelines for zeta potential analysis of nano particles. Retrieve from http://nanocomposix.com/sites/default/files/nanoComposix%20Guidelines%20for%20Zeta%20Potential%20Analysis%20of%20Nanoparticles.pdf. Accessed 20 March 2014.
  95. O’Dwyer, S. P., O’Beirne, D., Eidhin, D. N., Hennessy, A. A., & O’Kennedy, B. T. (2013). Formation, rheology and susceptibility to lipid oxidation of multiple emulsions (o/w/o) in table spreads containing omega-3 rich oils. Lebensmittel-Wissenschaft und Technologie - Food Science and Technology, 51(2), 484–491.Google Scholar
  96. O’Regan, J., & Mulvihill, D. M. (2009a). Water soluble inner aqueous phase markers as indicators of the encapsulation properties of water-in-oil-in-water emulsions stabilized with sodium caseinate. Food Hydrocolloids, 23(8), 2339–2345.Google Scholar
  97. O’Regan, J., & Mulvihill, D. M. (2009b). Preparation, characterisation and selected functional properties of sodium caseinate-maltodextrin conjugates. Food Chemistry, 115(4), 1257–1267.Google Scholar
  98. O’Regan, J., & Mulvihill, D. M. (2010). Sodium caseinate-maltodextrin conjugate stabilized double emulsions: encapsulation and stability. Food Research International, 43(1), 224–231.Google Scholar
  99. Okochi, H., & Nakano, M. (2000). Preparation and evaluation of w/o/w type emulsions containing vancomycin. Advanced Drug Delivery Reviews, 45(1), 5–26.Google Scholar
  100. Omotosho, J. A., Whateley, T. L., Law, T. K., & Florence, A. T. (1986). The nature of the oil phase and the release of solutes from multiple (w/o/w) emulsions. Journal of Pharmacy and Pharmacology, 38(12), 865–870.Google Scholar
  101. Onwulata, C. I. (2012). Encapsulation of new active ingredients. Annual Review of Food Science and Technology, 3, 183–202.Google Scholar
  102. Owusu, R. K., Zhu, Q., & Dickinson, E. (1992). Controlled release of L-tryptophan and vitamin B2 from model water/oil/water multiple emulsions. Food Hydrocolloids, 6(5), 443–453.Google Scholar
  103. Pal, R. (2008). Viscosity models for multiple emulsions. Food Hydrocolloids, 22(3), 428–438.Google Scholar
  104. Pays, K., Giermanska-Kahn, J., Pouligny, B., Bibette, J., & Leal-Calderon, F. (2002). Double emulsions: how does release occur? Journal of Controlled Release, 79(1–3), 193–205.Google Scholar
  105. Perrechil, F. A., Santana, R. C., Lima, D. B., Polastro, M. Z., & Cunha, R. L. (2014). Emulsifying properties of Maillard conjugates produced from sodium caseinate and locust bean gum. Brazilian Journal of Chemical Engineering, 31(02), 429–438.Google Scholar
  106. Pimentel-González, D. J., Campos-Montiel, R. G., Lobato-Calleros, C., Pedroza-Islas, R., & Vernon-Carter, E. J. (2009). Encapsulation of Lactobacillus rhamnosus in double emulsions formulated with sweet whey as emulsifier and survival in simulated gastrointestinal conditions. Food Research International, 42(2), 292–297.Google Scholar
  107. Prakash, W. V. (2012). Studies on design of micro/nano emulsion based delivery system for potential nutraceuticals using dairy based ingredients. Masters in Technology thesis in Dairy Technology submitted to National Dairy Research Institute (Deemed University), Karnal, Haryana, India.Google Scholar
  108. Rambhau, D., Phadke, D. S., & Dorle, A. K. (1977). Evaluation of o/w emulsion stability through zeta potential-I. Journal of the Society of Cosmetic Chemists, 28(4), 183–196.Google Scholar
  109. Rao, J., & McClements, D. J. (2010). Stabilization of phase inversion temperature nanoemulsions by surfactant displacement. Journal of Agricultural and Food Chemistry, 58(11), 7059–7066.Google Scholar
  110. Rodríguez-Huezo, M. E., Pedroza-Islas, R., Prado-Barragán, L. A., Beristain, C. I., & Vernon-Carter, E. J. (2004). Microencapsulation by spray drying of multiple emulsions containing carotenoids. Journal of Food Science, 69(7), 351–359.Google Scholar
  111. Rosano, H. L., Gandolfo, F. G., & Hidrot, J. P. (1998). Stability of w1/o/w2 multiple emulsions: influence of ripening and interfacial interactions. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 138(1), 109–121.Google Scholar
  112. Sapei, L., Naqvi, M. A., & Rousseau, D. (2012). Stability and release properties of double emulsions for food applications. Food Hydrocolloids, 27(2), 316–323.Google Scholar
  113. Scherze, I., Knöfel, R., & Muschiolik, G. (2005). Automated image analysis as a control tool for multiple emulsions. Food Hydrocolloids, 19(3), 617–624.Google Scholar
  114. Scherze, I., Knoth, A., & Muschiolik, G. (2006). Effect of emulsification method on the properties of lecithin- and PGPR-stabilized water-in-oil-emulsions. Journal of Dispersion Science and Technology, 27(4), 427–434.Google Scholar
  115. Schmitt, C., Sanchez, C., Desobry-Banon, S., & Hardy, J. (1998). Structure and techno-functional properties of protein-polysaccharide complexes: a review. Critical Reviews in Food Science and Nutrition, 38(8), 689–753.Google Scholar
  116. Shaw, L. A., McClements, D. J., & Decker, E. A. (2007). Spray-dried multilayered emulsions as a delivery method for ω-3 fatty acids into food systems. Journal of Agricultural and Food Chemistry, 55(8), 3112–3119.Google Scholar
  117. Shepherd, R., Robertson, A., & Ofman, D. (2000). Dairy glycoconjugate emulsifiers: casein-maltodextrin. Food Hydrocolloids, 14(4), 281–286.Google Scholar
  118. Silva, M. R., Contente, D. M. L., & Filho, P. A. R. (1997). Ascorbic acid liberation from o/w/o multiple emulsions. Cosmetics and Toiletries, 112(12), 85–87.Google Scholar
  119. Srinivasan, M. (1998). Formation and stability of oil-in-water caseinate emulsions. Doctor of Philosophy thesis in Food Technology submitted to Riddet Institute. Palmerston North, New Zealand: Massey University.Google Scholar
  120. Stevanovic, M., & Uskokovic, D. (2009). Poly(lactide-co-glycolide)-based micro and nanoparticles for the controlled drug delivery of vitamins. Current Nanoscience, 5(1), 1–14.Google Scholar
  121. Su, J. (2008). Formation and stability of food-grade water-in-oil-in-water emulsions. Doctor of Philosophy in Food Technology thesis submitted to Riddet Institute. Palmerston North, New Zealand: Massey University.Google Scholar
  122. Su, J., Flanagan, J., & Singh, H. (2008). Improving encapsulation efficiency and stability of water-in-oil-in-water emulsions using a modified gum Arabic (Acacia: Super GUM). Food Hydrocolloids, 22(1), 112–120.Google Scholar
  123. Su, J., Flanagan, J., Hemar, Y., & Singh, H. (2006). Synergistic effects of polyglycerol ester of polyricinoleic acid and sodium caseinate on the stabilisation of water-oil-water emulsions. Food Hydrocolloids, 20(2–3), 261–268.Google Scholar
  124. Tadros, T. F. (2008). Colloids in cosmetics and personal care (Vol. 4). Weinheim: Wiley.Google Scholar
  125. Tadros, T. F., Taelman, M. C., & Dederen, J. C. (1998). Multiple emulsions with polymeric surfactants. In J. L. Grossiord & M. Seiller (Eds.), Multiple emulsions: structure, properties and applications (pp. 117–137). Paris: Editions de Sante.Google Scholar
  126. Taki, J., Isomura, T., Kanda, K., Kawahara, A., Maruyama, K., & Kusumoto, S. (2007). w1/o/w2-type double emulsion dressing and method for production thereof. Japan Patent No. JP.PCT/JP2006/320550.Google Scholar
  127. Tavani, A., Spertini, L., Bosetti, C., Parpinel, M., Gnagarella, P., Bravi, F., et al. (2006). Intake of specific flavonoids and risk of acute myocardial infarction in Italy. Public Health Nutrition, 9(3), 369–374.Google Scholar
  128. van der Graff, S., Schroen, C. G. P. H., & Boom, R. M. (2005). Preparation of double emulsions by membrane emulsification: a review. Journal of Membrane Science, 251(1–2), 7–15.Google Scholar
  129. van-Gils, C. H., Peeters, P. H., & Bueno-de-Mesquita, H. B. (2005). Consumption of vegetables and fruits and risk of breast cancer. Journal of the American Medical Association, 293(2), 183–193.Google Scholar
  130. Vega, C., & Roos, Y. H. (2006). Invited review: spray-dried dairy and dairy-like emulsions-compositional considerations. Journal of Dairy Science, 89(2), 383–401.Google Scholar
  131. Vermeir, L. (2011). Formulation and characterization aspects of low fat whipping cream by water/oil/water technology. Master of Science in Food Technology thesis submitted to The Faculty of Bioscience Engineering. Belgium: Katholieke Universiteit Leuven.Google Scholar
  132. Vladisavljevic, G. T., & Williams, R. A. (2005). Recent developments in manufacturing emulsions and particulate products using membranes. Advances in Colloid and Interface Science, 113(1), 1–20.Google Scholar
  133. Walstra, P. (2003). Physical chemistry of foods. New York: Marcel Decker.Google Scholar
  134. WHO/FAO. (2002). Diet, nutrition and the prevention of chronic diseases: report of a Joint FAO/WHO consultation, Geneva, 28 January- 1 February 2002. Geneva: WHO.Google Scholar
  135. Xu, J. H., Chen, R., Wang, Y. D., & Luo, G. S. (2012). Controllable gas/liquid/liquid double emulsions in a dual-coaxial microfluidic device. Lab on a Chip, 12(11), 2029–2036.Google Scholar
  136. Xu, J. H., Ge, X. H., Chen, R., & Luo, G. S. (2014). Microfluidic preparation and structure evolution of double emulsions with two phase cores. RSC Advances, 4, 1900–1906.Google Scholar
  137. Yan, J., & Pal, R. (2001). Osmotic swelling behaviour of globules of W/O/W emulsion liquid membranes. Journal of Membrane Science, 190(1), 79–91.Google Scholar
  138. Yoshida, K., Sekine, T., Matsuzaki, F., Yanaki, T., & Yamaguchi, M. (1999). Stability of vitamin A in oil-in-water-in-oil type multiple emulsions. Journal of the American Oil Chemists Society, 76(2), 195–200.Google Scholar
  139. Zeeb, B., Zhang, H., Gibis, M., Fischer, L., & Weiss, J. (2013). Influence of buffer on the preparation of multilayered oil-in-water emulsions stabilized by proteins and polysaccharides. Food Research International, 53(1), 325–333.Google Scholar

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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Dairy Technology DivisionNational Dairy Research InstituteKarnalIndia

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