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Cellular Automata Modeling of Hesperetin Release Phenomenon from Lipid Nanocarriers

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Abstract

Release behavior of encapsulated food bioactives is an important issue which has not been befittingly studied. Cellular automaton is a mathematical model that shows complex systems can be simulated based on interactions of their constructing components. In this research, cellular automata were proposed for simulating encapsulant release through lipid nanocarriers via diffusion mechanism in order to know effects of different parameters, e.g., encapsulant load, kind of neighborhood, probability of encapsulant solubility, encapsulant distribution, and type of release medium in two and three dimensions. The simulation results were validated using experimental hesperetin release data which showed good agreement indicating the ability of cellular automata to enhance the resolution over the complexity of the diffusion phenomenon during encapsulant release from nanocarriers.

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Acknowledgment

The authors would like to acknowledge the Iran National Science Foundation (INSF) for financial support under grant number of 89004288.

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Authors and Affiliations

  1. Department of Food Science and Technology, Faculty of Agriculture, Isfahan University of Technology, Isfahan, 84156-83111, Iran

    Milad Fathi

  2. Department of Food Science and Technology, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran

    Mohebbat Mohebbi & Fakhri Shahidi

  3. Department of Pharmaceutics, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

    Jaleh Varshosaz

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  1. Milad Fathi
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  2. Mohebbat Mohebbi
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  3. Jaleh Varshosaz
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  4. Fakhri Shahidi
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Correspondence to Milad Fathi.

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Fathi, M., Mohebbi, M., Varshosaz, J. et al. Cellular Automata Modeling of Hesperetin Release Phenomenon from Lipid Nanocarriers. Food Bioprocess Technol 6, 3134–3142 (2013). https://doi.org/10.1007/s11947-012-0995-2

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  • DOI: https://doi.org/10.1007/s11947-012-0995-2

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