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Invited Commentary on Preventive Anti-Migraine Therapy (PAMT)


Migraine is a chronic paroxysmal neurological disorder characterized by multiphase attacks of head pain and a myriad of neurological symptoms. Chronic migraine causes a great personal and societal burden. Many patients are poorly responsive to, or non-compliant with, conventional migraine preventive therapies. For this reason, physicians are constantly looking for effective migraine prevention strategies. The recent introduction of an innovative pharmacological class useful for migraine prevention, namely monoclonal antibodies towards calcitonin gene-related peptide or its receptors, opens a new, immense therapeutic scenario. In this commentary, the development and efficacy of this novel class of preventive anti-migraine therapy have been discussed and compared with the conventional therapies of migraine prevention.

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Corresponding author

Correspondence to Sameer Jain MD.

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Conflict of Interest

Stephen D. Silberstein reports personal fees from Alder Biopharmaceuticals, Allergan, Inc., Amgen, Avanir Pharmaceuticals, Inc., Curelator, Inc., Dr. Reddy’s Laboratories, eNeura Inc., electroCore Medical, LLC, Lilly USA, LLC, Supernus Pharmaceuticals, Inc., Teva Pharmaceuticals, Theranica, Trigemina, Inc., Medscape, LLC, Abide Therapeutics, Biohaven Pharmaceuticals, Cefaly, Egalet, and GlaxoSmithKline, outside the submitted work. Sameer Jain reports no potential conflict of interest.

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Jain, S., Silberstein, S.D. Invited Commentary on Preventive Anti-Migraine Therapy (PAMT). Curr Treat Options Neurol 21, 14 (2019).

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  • Migraine
  • CGRP monoclonal antibody
  • Migraine prevention
  • CGRP receptor
  • Fremanezumab
  • Erenumab
  • Galcanezumab
  • New migraine treatments
  • Migraine prophylaxis