Biotherapy in Inflammatory Diseases of the CNS: Current Knowledge and Applications

  • Nicolas Collongues
  • Laure Michel
  • Jérôme de Seze
Multiple Sclerosis and Related Disorders (P Villoslada, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Multiple Sclerosis and Related Disorders

Opinion statement

Biotherapy represents an innovative therapeutic approach that includes immunotherapy (vaccines, apheresis, and antibodies); gene therapy; and stem cell transplants. Their development helps to cross the bridge from bench to bedside and brings new hope of a cure for severe diseases in different fields of medicine. In neurology, a growing range of applications is being developed for these medications. Valuable results are now available in the field of autoimmunity, neuro-oncology, paraneoplastic manifestations, and neurodegenerative disorders. In this review, we examine the current and future applications of biotherapy in the field of inflammation of the central nervous system. We demonstrate its contribution in clinical practice, where it has enabled a significant level of effectiveness to be achieved. Indeed, the efficacy of these new biodrugs provides a solution for patients refractory to standard therapies, such as intravenous immunoglobulins in limbic encephalitis, plasma exchanges in neuromyelitis optica and anti-CD20 monoclonal antibodies in multiple sclerosis. They also mark the first steps towards individualized medicine.


Biotherapy Monoclonal antibody Stem cell Gene therapy 


Compliance with Ethical Standard

Conflict of Interest

Nicolas Collongues has received board membership fees, honoraria, and paid travel accommodations from Biogen, Merck, Novartis, and Sanofi. Laure Michel has received honoraria payments from Genzyme and Roche and paid travel accommodations from Novartis. Jérôme de Seze has received board membership fees from Biogen, Genzyme, Teva, Merck, Novartis, and Roche.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Département de NeurologieCHU de StrasbourgStrasbourgFrance
  2. 2.Centre d′investigation cliniqueINSERMStrasbourgFrance
  3. 3.Département de neurologieCHU de NantesNantesFrance

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