Management of Cirrhotic Patients After Successful HCV Eradication

  • Ryan M. KwokEmail author
  • Tram T. Tran
Liver (J Bajaj, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Liver

Opinion statement

Chronic hepatitis C (HCV) is a hepatotropic virus which, when untreated, can lead to progressive inflammation and fibrosis resulting in cirrhosis, hepatocellular carcinoma (HCC), and decompensations related to end-stage liver disease. The relatively recent introduction of all oral, interferon-free, direct-acting antiviral medications against HCV has transformed the management of these patients. Previous treatment regimens were prolonged, poorly tolerated, and frequently did not result in cure. Current therapies achieve sustained viral response (SVR) in the vast majority of patients including those with decompensated liver disease; a previously challenging population to treat. These successes will result in significant numbers of cirrhotic patients requiring management after SVR. Although many complications of cirrhosis are improved in this setting, regular follow-up of HCC, esophageal varices, and other sequelae of cirrhosis will be necessary. This chapter will review the management of cirrhosis in HCV patients achieving cure.


Hepatitis C Cirrhosis Decompensated liver disease Gastroesophageal varices Ascites Hepatic encephalopathy Hepatocellular carcinoma Sustained virologic response Portal hypertension 


Compliance with Ethical Standards

Conflict of Interest

Ryan M. Kwok declares no conflict of interest.

Tram T. Tran declares grants and personal fees from Gilead Sciences, BMS, AbbVie, Merck, and Janssen.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC (outside the USA) 2017

Authors and Affiliations

  1. 1.Division of Gastroenterology/HepatologyWalter Reed National Military Medical CenterBethesdaUSA
  2. 2.Cedars-Sinai Medical Center Liver TransplantationLos AngelesUSA

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