Opinion statement
Nocturnal acid breakthrough is misunderstood and infrequently requires treatment in everyday practice. There are important subgroups of patients in whom esophageal reflux occurs in the presence of nocturnal acid breakthrough in which treatment may be needed.
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References and Recommended Reading
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Katz, P.O., Dudnick, R.S. Nocturnal acid breakthrough on proton pump inhibitor therapy: To treat or not to treat. Curr Treat Options Gastro 11, 29–34 (2008). https://doi.org/10.1007/s11938-008-0004-z
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DOI: https://doi.org/10.1007/s11938-008-0004-z