Skip to main content

Management of esophageal strictures in children

Opinion statement

Esophageal dilatation remains the primary treatment of esophageal strictures. Aggressive esophageal dilatation is indicated regardless of the etiology and length of the stricture. Esophageal dilatation causes iatrogenic trauma and tearing of scar tissue that may result in restricturing. Local infiltration of triamcinolone into the stricture site at the time of dilatation may markedly reduce subsequent scar formation and restricturing. Intralesional triamcinolone is most useful for short strictures and may decrease the need for future dilatation. Successful management of esophageal strictures requires the aggressive treatment of all pathogenic processes contributing to esophageal inflammation and restricturing following dilatation. Medically uncontrolled reflux esophagitis may require antireflux surgery to successfully dilate the stricture. Balloon dilators apply only radial forces and no longitudinal, shearing forces. They are most useful for two situations: circumstances under which it is desirable to minimize esophageal trauma (eg, epidermolysis bullosa) and short strictures. Savary-Gilliard dilators are useful for strictures resistant to balloon dilatation and for long strictures that require carefully controlled and graded dilatation. We routinely use dilators instead of guide wires for long strictures, multiple strictures, tortuous esophagus, and very narrow strictures, particularly when the state of the esophagus distal to the stricture is unclear. Failure of aggressive, frequent dilatation to maintain sufficient esophageal luminal diameter may necessitate surgical intervention (ie, resection of the stricture or esophageal replacement).

This is a preview of subscription content, access via your institution.

References and Recommended Reading

  1. Ketchum LD, Smith J, Robinson DW, Masters FW: The treatment of hypertrophic scar, keloid and scar contracture by triamcinolone acetonide. J Plast Reconstr Surg 1996, 38:209–214.

    Google Scholar 

  2. Ashcraft KW, Holder TM: The experimental treatment of esophageal strictures by intralesional steroid injections. J Thorac Cardiovasc Surg 1996, 58:685–693.

    Google Scholar 

  3. Holder TM, Ashcraft KW, Leape L: The treatment of patients with esophageal strictures by local steroid injections. J Pediatr Surg 1969, 4:646–653.

    PubMed  Article  CAS  Google Scholar 

  4. Mendelson HJ, Maloney WH: The treatment of benign strictures of the esophagus with cortisone injection. Ann Otol Rhinol Laryngol 1970, 79:900–904.

    Google Scholar 

  5. Kirsch M, Blue M, Desai RK, et al.: Intralesional steroid injections for peptic esophageal strictures. Gastrointest Endosc 1991, 37:118–182.

    Article  Google Scholar 

  6. Berenson GA, Wylie R, Caulfield M, et al.: Intralesional steroids in the treatment of refractory esophageal strictures. J Pediatr Gastroenterol Nutr 1994, 18:250–252.

    PubMed  CAS  Article  Google Scholar 

  7. Lee M, Kubik CM, Polhamus CD, et al.: Preliminary experience with endoscopic intralesional steroid injection therapy for refractory upper gastrointestinal strictures. Gastrointest Endosc 1994, 41:598–601.

    Article  Google Scholar 

  8. Kochar R, Ray JD, Sriram PV, et al.: Intralesional steroids augment the effects of endoscopic dilatation in corrosive esophageal strictures. Gastrointest Endosc 1999, 49:509–513.

    Article  Google Scholar 

  9. Kochar R, Makharia GK: Usefulness of intralesional triamcinolone in treatment of benign of esophageal strictures. Gastrointest Endosc 2002, 56:829–834.

    Article  Google Scholar 

  10. Andersen JM: Treatment of esophageal strictures with intralesional steroids [abstract]. Gastrointest Endosc 1995, 41:332A.

    Article  Google Scholar 

  11. Rahbar R, Jones DT, Nuss RC, et al.: The role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract. Arch Otolaryngol Head Neck Surg 2002, 128:401–406. This paper demonstrates the benefit of using mitomycin in the reduction of scar formation after dilatation.

    PubMed  Google Scholar 

  12. Rodgers BM, McGahren III ED: Esophagus. In Surgery of Infants and Children: Scientific Principals and Practice. Edited by Oldham KT, Colombani PM, Foglia RP. Philadelphia: Lippincott-Raven Publishers; 1997:1005–1019.

    Google Scholar 

  13. Hassell E, Isreal D, Shepherd R, et al.: Omeprazole for treatment of chronic erosive esophagitis in children: a multicenter study of efficacy, safety, tolerability, and dose requirements. International Pediatric Omeprazole Study Group. J Pediatr 2000, 137:800–807. This multicenter study reports the adequate dosages of protonpump inhibitors in the treatment of children with esophagitis.

    Article  Google Scholar 

  14. DiGiancinto JL, Olsen KM, Bergman KL, et al.: Stability of suspension of formulations of lansoprazole and omeprazole. Am J Health Syst Pharm 1999, 94:1813–1817.

    Google Scholar 

  15. Sharma VK, Peyton B, Spears T, et al.: Oral pharmacokinetics of Omeprazole and Lansoprazole after single and repeated doses as intact capsules or as suspensions in sodium bicarbonate. Aliment Pharmacol Ther 2000, 14:887–892. This study showed that lansoprazole solution is more efficacious than omeprazole solution.

    PubMed  Article  CAS  Google Scholar 

  16. Chanin TN, Schuster MM, Crowell MD, et al.: Effects of low doses of erythromycin on gastrointestinal motility and symptoms in chronic intestinal pseudoobstruction [abstract]. Gastroenterology 1991, 100:41.

    Google Scholar 

  17. Fry SW, Fleischer DE: Management of a refractory benign esophageal stricture with a new biodegradable stent. Gastrointest Endosc 1997, 45:179–182.

    PubMed  Article  CAS  Google Scholar 

  18. Zarityzky M, Hauri J, Berghoff R, et al.: Uso de stents en patologia benigna de esofago en pediatria. Intervencionismo 2002, 2:1.

    Google Scholar 

  19. Fiorini A, Fleischer D, Valero J, et al.: Self-expandable metal coil stents in the treatment of benign esophageal strictures refractory to conventional therapy: a case series. Gastrointest Endosc 2000, 52:259–262.

    PubMed  Article  CAS  Google Scholar 

  20. Lee JG, Hsu R, Leung JW: Are self-expanding metal mesh stents useful in the treatment of benign esophageal stenosis and fistulas? An experience of four cases. Am J Gastroenterol 2000, 95:1920–1925.

    PubMed  Article  CAS  Google Scholar 

  21. Pintus C, Valeri S, Riccioni M, et al.: Recurrent peptic stenosis of the esophagus: treatment with a selfexpanding metallic stent. Surg Laparosc Endosc Percutaneous Tech 2000, 10:401–403.

    Article  CAS  Google Scholar 

  22. Ackroyd R, Watson DI, Devitt PG, Jamieson GG: Expandable metallic stents should not be used in the treatment of esophageal strictures. J Gastroenterol Hepatol 2001, 16:484–487.

    PubMed  Article  CAS  Google Scholar 

  23. Catnach S, Barrison I: Self-expanding metal stents for the treatment of benign esophageal strictures. Gastrointest Endosc 2001, 54:140.

    PubMed  Article  CAS  Google Scholar 

  24. Brandimarte G, Tursi A: Endoscopic treatment of benign anastomotic esophageal stenosis with electrocautery. Endoscopy 2002, 34:339–401. This article reports successful use of electrocautery in esophageal strictures.

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Rodriguez-Baez, N., Andersen, J.M. Management of esophageal strictures in children. Curr Treat Options Gastro 6, 417–425 (2003). https://doi.org/10.1007/s11938-003-0044-3

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11938-003-0044-3

Keywords

  • Lansoprazole
  • Guide Wire
  • Main Side Effect
  • Main Drug Interaction
  • Rabeprazole