Skip to main content
SpringerLink
Log in

Gastroesophageal reflux disease

  • Published:
Current Treatment Options in Gastroenterology Aims and scope Submit manuscript

Opinion statement

Lifestyle modifications should be discussed with every patient with symptoms of chronic gastroesophageal reflux disease (GERD). Proton pump inhibitors are the most efficacious medical therapy for GERD. H2 receptor antagonists are likely to be effective in patients with mild to moderate GERD and for occasional symptoms. Promotility drugs have limited efficacy and produce frequent side effects. Surgery is a reasonable option for chronic management. Endoscopic therapy remains experimental until more long-term results are available.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References and Recommended Reading

  1. Nebel OT, Fornes MF, Castell DO: Symptomatic gastroesophageal reflux: incidence and precipitating factors. Am J Dig Dis 1976, 21:953–956.

    Article  PubMed  CAS  Google Scholar 

  2. Howard PJ, Heading RC: Epidemiology of gastroesophageal reflux disease. World J Surg 1992, 16:288–293.

    Article  PubMed  CAS  Google Scholar 

  3. Locke GR III, Talley NJ, Fett SL, et al.: Prevalence and clinical spectrum of gastroesophageal reflux disease: a population based study in Olmstead County, Minnesota. Gastroenterology 1997, 112:1448–1456.

    Article  PubMed  Google Scholar 

  4. Richter JE. Gastroesophageal reflux disease in the older patient: presentation, treatment and complications. Am J Gastroenterol 2000, 95:368–373.

    PubMed  CAS  Google Scholar 

  5. Hetzel D, Dent J, Reed W, et al.: Healing and relapse of severe peptic esophagitis after treatment with omeprazole. Gastroenterology 1988, 95:903–912.

    PubMed  CAS  Google Scholar 

  6. Khoury RM, Camacho-Lobato Katz PO, et al.: Influence of spontaneous sleep positions on nighttime recumbent reflux in patients with the gastroesophageal reflux disease. Am J Gastroenterol 1999, 94:2069–2073.

    Article  PubMed  CAS  Google Scholar 

  7. DeVault KR, Castell DO: Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol 1999;94:1435–1442. A comprehensive review on the diagnosis and treatment of GERD.

    Article  Google Scholar 

  8. Iskedjian M, Einarson TR.: Meta-analyses of cisapride, omeprazole and ranitidine in the treatment of GORD: implications for treating patient subgroups. Clin Drug Invest 1998, 16:9–18.

    Article  CAS  Google Scholar 

  9. Wolfe MM, Sachs G: Acid suppression: optimizing therapy for gastroduodenal ulcer healing, gastroesophageal reflux disease, and stress-related erosive syndrome. Gastroenterology 2000, 118(Suppl):S9-S31.

    Article  PubMed  CAS  Google Scholar 

  10. Dent J, Brun J, Fendrick AM, et al.: An evidence-based appraisal of reflux disease management—the Genval workshop report. Gut 1999, 44(Suppl):S1-S16.

    Article  Google Scholar 

  11. Klinkenbberg-Knol E, Nelis F, Dent J, et al.: Long-term omeprazole treatment in resistant gastroesophageal reflux disease. Gastroenterology 2000, 118:661–669. An important study documenting the effectiveness of longterm PPI therapy for GERD.

    Article  Google Scholar 

  12. Peghini PL, Katz PO, Bracy NA, et al.: Nocturnal recovery of gastric acid secretion with twice daily dozing of proton pump inhibitors. Am J Gastroenterol 1998, 93:763–767. A excellent study proving and introducing the concept of nocturnal acid breakthrough on PPI therapy.

    Article  PubMed  CAS  Google Scholar 

  13. Katz PO, Anderson C, Khoury R, et al.: Gastroesophageal reflux associated with nocturnal gastric acid breakthrough on proton pump inhibitors. Aliment Pharmacol Ther 1998, 12:1231–1234.

    Article  PubMed  CAS  Google Scholar 

  14. Peghini PL, Katz PO, Castell DO: Ranitidine controls nocturnal gastric acid breakthrough on omeprazole: a controlled study in normal subjects. Gastroenterology 1998, 115:1335–1339.

    Article  PubMed  CAS  Google Scholar 

  15. Lundell L, Miettinen P, Myrvold HE, et al.: A randomized comparison between omeprazole and it opened anti-reflux surgery in the management of chronic gastro-esophageal reflux disease: report on 5 year follow up [abstract]. Gut 1999, 45(Suppl 5):A40.

    Google Scholar 

  16. Holloway R, Dent J: Pathophysiology of gastroesophageal reflux: lower esophageal sphincter dysfunction in gastroesophageal disease. Gastroenterol Clin North Am 1990, 19:517–535.

    PubMed  CAS  Google Scholar 

  17. Howden CW, Castell DO, Cohen S, et al.: The rationale for continuous maintenance treatment of reflux esophagitis. Arch Intern Med 1995, 155:1465–1471.

    Article  PubMed  CAS  Google Scholar 

  18. Hunt RH: Importance of pH control in the management of GERD. Arch Intern Med 1999, 159:649–657.

    Article  PubMed  CAS  Google Scholar 

  19. Lundell L, Miettinen P, Myrvold H, et al.: Continued follow-up of a randomized clinical study comparing antireflux surgery and omeprazole in gastroesophageal reflux disease. J Am Coll Surg 2001;192:172–179.

    Article  PubMed  CAS  Google Scholar 

  20. Lundell L, Miettinen P, Myrvold HE, et al.: Long-term management of gastroesophageal reflux disease with omeprazole or open anti-reflux surgery: results of a prospective, randomized clinical trial. Eur J Gastroenterol Hepatol 2000, 12:879–887.

    Article  PubMed  CAS  Google Scholar 

  21. Triadafilopoulos G, Dibaise JK, Nostrant TT, et al.: The Stretta procedure for the treatment of GERD: 6 and 12 month follow-up of the U.S. open label trial. Gastrointest Endosc 2002, 55:149–156. An important study giving us the first long-term data on the efficacy of the Stretta procedure.

    Article  PubMed  Google Scholar 

  22. Gersin K, Fanelli R: The Stretta procedure: review of catheter and technique evolution, efficacy and complications 2 years after introduction. Surg Endosc 2002, 16(Suppl 1):PF199.

    Google Scholar 

  23. Filipi C, Lehman G, Rothstein RI, et al.: Transoral endoscopic suturing for gastroesophageal reflux disease: a multicenter trial. Gastrointest Endosc 2001, 53:416–422.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Digestive Disease Center, Medical University of South Carolina, 96 Jonathan Lucas Street, 210 Clinical Science Building, 29425, Charleston, SC, USA

    Amine Hila MD & Donald O. Castell MD

Authors
  1. Amine Hila MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Donald O. Castell MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hila, A., Castell, D.O. Gastroesophageal reflux disease. Curr Treat Options Gastro 6, 41–48 (2003). https://doi.org/10.1007/s11938-003-0032-7

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11938-003-0032-7

Keywords

Search

Navigation