Current Treatment Options in Gastroenterology

, Volume 4, Issue 1, pp 73–81 | Cite as

Gastroesophageal reflux disease in pregnancy

  • Mohan Charan
  • Philip O. Katz

Opinion statement

Gastroesophageal reflux disease (GERD) in pregnancy presents a special challenge for the clinician, predominantly because of the potential side effects of pharmacologic interventions on the fetus. Lifestyle and dietary modifications, change in sleeping posture, and antacid medications are emphasized, as these options pose little risk to the fetus. When these interventions are not successful, sucralfate, a mucosal protectant with little to no systemic absorption, should be considered next. Therapy with H2 receptor antagonists or proton pump inhibitors can be considered in patients with refractory symptoms; though not approved for this use, they are likely safe, particularly in third trimester. Prokinetic agents should be used with extreme caution or avoided altogether in the pregnant patient.


Omeprazole Gastroesophageal Reflux Lansoprazole Aluminum Hydroxide Cisapride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Science Inc 2001

Authors and Affiliations

  • Mohan Charan
    • 1
  • Philip O. Katz
    • 1
  1. 1.Division of Gastroenterology, Department of MedicineThe Graduate HospitalPhiladelphiaUSA

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