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Esophageal leiomyomas

Current Treatment Options in Gastroenterology volume 3, pages 71–76 (2000)Cite this article

Opinion statement

Esophageal leiomyomas are often discovered incidentally when a barium swallow or endoscopic examination performed for unrelated reasons reveals a smooth, submucosal mass in the esophagus. Although surgical removal and histologic examination are required to prove the diagnosis, a diagnosis of esophageal leiomyoma can be established with reasonable certainty by a careful clinical evaluation that includes endoscopy, endoscopic ultrasonography (EUS), and CT scan. If these tests reveal any feature that suggests malignancy, or if the tumor is causing symptoms, the lesion should be removed surgically, provided there is no severe co-morbidity or evidence of metastatic disease. If the imaging studies are typical of benign leiomyoma and the patient has no symptoms, therapy should be individualized. The limited data available on the natural history of esophageal leiomyomas suggests that the tumors grow slowly and that malignant transformation is extremely uncommon.

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References and Recommended Reading

  1. Seremetis MG, Lyons WS, De Guzman VC, Peabody JWJr: Leiomyomata of the esophagus: an analysis of 838 cases. Cancer 1976, 38:2166–2177. An excellent review of the clinical and histologic features of esophageal leiomyoma.

    PubMed  Article  CAS  Google Scholar 

  2. Takubo K, Nakagawa H, Tsuchiya S, et al.: Seedling leiomyoma of the esophagus and esophagogastric junction zone. Hum Pathol 1981, 12:1006–1010.

    PubMed  CAS  Google Scholar 

  3. Levine MS, Buck JL, Pantongrag-Brown L, et al.: Esophageal leiomyomatosis. Radiology 1996, 199:533–536.

    PubMed  CAS  Google Scholar 

  4. Massari M, Lattuada E, Zappa MA, et al.: Evaluation of leiomyoma of the esophagus with endoscopic ultrasonography. Hepatogastroenterology 1997, 44:727–731. This article summarizes the endosonographic features of esophageal leiomyoma, and describes how endosonography is used to formulate management decisions for patients with submucosal esophageal tumors.

    PubMed  CAS  Google Scholar 

  5. Rendina EA, Venuta F, Pescarmona EO, et al.: Leiomyoma of the esophagus. Scand J Thorac Cardiovasc Surg 1990, 24:79–82.

    PubMed  CAS  Google Scholar 

  6. Evans HL: Smooth muscle tumors of the gastrointestinal tract: a study of 56 cases followed for a minimum of 10 years. Cancer 1985, 56:2242–2250.

    PubMed  Article  CAS  Google Scholar 

  7. Bonavina L, Segalin A, Rosati R, et al.: Surgical therapy of esophageal leiomyoma. J Am Coll Surg 1995, 181:257–262.

    PubMed  CAS  Google Scholar 

  8. Geller A, Wang KK, DiMagno EP: Diagnosis of foregut duplication cysts by endoscopic ultrasonography. Gastroenterology 1995, 109:838–842. This article summarizes how endosonography can be used to distinguish cystic from solid submucosal lesions of the esophagus.

    PubMed  Article  CAS  Google Scholar 

  9. Rafal RB, Markisz JA: Magnetic resonance imaging of an esophageal duplication cyst. Am J Gastroenterol 1991, 86:1809–1811.

    PubMed  CAS  Google Scholar 

  10. Massari M, De Simone M, Cioffi U, et al.: Endoscopic ultrasonography in the evaluation of leiomyoma and extramucosal cysts of the esophagus. Hepatogastroenterology 1998, 45:938–943.

    PubMed  CAS  Google Scholar 

  11. Rösch T, Lorenz R, Dancygier H, et al.: Endosonographic diagnosis of submucosal upper gastrointestinal tract tumors. Scand J Gastroenterol 1992, 27:1–8.

    PubMed  Google Scholar 

  12. Glanz I, Grunebaum M: The radiological approach to leiomyoma of the oesophagus with a long-term follow-up. Clin Radiol 1977, 28:197–200. One of very few articles that deal with the natural history of esophageal leiomyomas. This report suggests that these tumors grow very slowly and that malignant transformation is rare.

    PubMed  Article  CAS  Google Scholar 

  13. Basic Pathology, 6th edn. Edited by Kumar V, Cotran RS, Robbins SL. Philadelphia: W.B. Saunders Co.; 1997:611.

    Google Scholar 

  14. Shamji F, Todd TRJ: Benign Tumors. In Esophageal Surgery. Edited by Pearson FG, Deslauriers J, Ginsberg RJ, et al. New York: Churchill Livingstone. 1995; 519–538.

    Google Scholar 

  15. Roviaro GC, Maciocco M, Varoli F, et al.: Videothoracoscopic treatment of oesophageal leiomyoma. Thorax 1998, 53:190–192.

    PubMed  CAS  Article  Google Scholar 

  16. Kajiyama T, Sakai M, Torii A, et al.: Endoscopic aspiration lumpectomy of esophageal leiomyomas derived from the muscularis mucosae. Am J Gastroenterol 1995, 90:417–422.

    PubMed  CAS  Google Scholar 

  17. Hyun JH, Jeen YT, Chun HJ, et al.: Endoscopic resection of submucosal tumor of the esophagus: results in 62 patients. Endoscopy 1997, 29:165–170. This report summarizes the results of endoscopic resection for esophageal leiomyomas.

    PubMed  CAS  Article  Google Scholar 

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Authors and Affiliations

  1. Division of Gastroenterology (111B1), Dallas VA Medical Center, 4500 Lancaster Road, 75216, Dallas, TX, USA

    Stuart Jon Spechler MD

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  1. Stuart Jon Spechler MD
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  2. Irving Waxman MD
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Spechler, S.J., Waxman, I. Esophageal leiomyomas. Curr Treat Options Gastro 3, 71–76 (2000). https://doi.org/10.1007/s11938-000-0063-2

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  • DOI: https://doi.org/10.1007/s11938-000-0063-2

Keywords

  • Leiomyomas
  • Muscularis Propria
  • Submucosal Tumor
  • Esophageal Resection
  • Granular Cell Tumor