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Cerebrovascular complications of fibromuscular dysplasia

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Opinion statement

Patients with cerebral ischemia or hemorrhage due to fibromuscular dysplasia (FMD) should be admitted to a monitored hospital bed and receive supportive stroke care. Based on our personal clinical experience, we recommend antiplatelet agents for future stroke prevention in patients with symptomatic FMD. In patients with watershed stroke due to hemodynamically significant FMD, our opinion is that hypertensive, hypervolemic therapy should be initiated immediately. Additionally, we suggest that potential revascularization therapies, such as intraoperative or primary percutaneous angioplasty, should be discussed.

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References and Recommended Reading

  1. Schievink WI, Meyer FB, Parisi JE, Wijdicks EF: Fibromuscular dysplasia of the internal carotid artery associated with alpha-1 antitrypsin deficiency. Neurosurgery 1998, 43:229–234.

    Article  PubMed  CAS  Google Scholar 

  2. Luscher TF, Stanson AW, Houser OW, et al.: Arterial fibromuscular dysplasia. Mayo Clin Proc 1987, 62:931–952.

    PubMed  CAS  Google Scholar 

  3. Begelman SM, Olin JW: Fibromuscular dysplasia. Curr Opin Rheumatol 2000, 12:41–47.

    Article  PubMed  CAS  Google Scholar 

  4. Gray BH, Young JR, Olin JW: Miscellaneous arterial diseases. In Peripheral Vascular Diseases. edn 2. Edited by Young JR, et al. St Louis, MO: Mosby Yearbook; 1996:425–440.

    Google Scholar 

  5. Lusher TF, Keller HM, Imhof HG, et al.: Fibromuscular hypoplasia: extension of the disease and therapeutic outcome; results of the University Hospital Zurich Cooperative Study on fibromuscular hypoplasia. Nephron 1986, 44(suppl 1):109–114.

    Google Scholar 

  6. Correll JW, Quest DO, Carpenter DB: Nonatheromatous lesions of the extracranial cerebral arteries. In Stroke and the Extracranial Vessels. Edited by Smith RR. New York, NY: Raven Press; 2000:321–331.

    Google Scholar 

  7. Heffelfinger MJ, Holley KE, Harrison EG Jr, Hunt JC: Arterial fibromuscular dysplasia studied at autopsy. Am J Clin Pathol 1970, 54:274–280.

    Google Scholar 

  8. Mettinger KL: Fibromuscular dysplasia and the brain. II. Current concept of the disease. Stroke 1982, 13:53–58.

    PubMed  CAS  Google Scholar 

  9. Mettinger KL, Ericsonn K: Fibromuscular dysplasia and the brain. I. Observations on angiographic, clinical, and genetic characteristics. Stroke 1982, 13:46–52.

    PubMed  CAS  Google Scholar 

  10. Harrison EG, McCormack LJ: Pathologic classification of renal arterial disease in renovascular hypertension. Mayo Clin Proc 1971, 46:161–167.

    PubMed  Google Scholar 

  11. Stanley JC, Gewertz BL, Bove EL, et al.: Arterial fibroplasias, histopathologic character and current etiologic concepts. Arch Surg 1975, 110:561–566.

    PubMed  CAS  Google Scholar 

  12. Alimi Y, Mercier C, Pèllissier JF, et al.: Fibromuscular disease of the renal artery: a new histopathologic classification. Ann Vasc Surg 1992, 6:220–224.

    Article  PubMed  CAS  Google Scholar 

  13. Rybka SJ, Novick AC: Concomitant carotid, mesenteric, and renal artery stenosis due to primary intimal fibroplasias. J Urol 1983, 129:798–800.

    PubMed  CAS  Google Scholar 

  14. Stokes JB, Bonsib SM, McBride JW: Diffuse intimal fibromuscular dysplasia with multiorgan failure. Arch Intern Med 1996, 156:2611–2614.

    Article  Google Scholar 

  15. So EL, Toole JF, Dalal P, Moody DM: Cephalic fibromuscular dysplasia in 32 patients. Arch Neurol 1981, 38:619–622.

    PubMed  CAS  Google Scholar 

  16. Tan AK, Venketasubramanian N, Tan CB, et al.: Ischaemic stroke from cerebral embolism in cephalic fibromuscular dysplasia. Ann Acad Med Singapore 1995, 24:891–894.

    PubMed  CAS  Google Scholar 

  17. Schievink WI, Bjornsson J: Fibromuscular dysplasia of the internal carotid artery: a clinicopathological study. Clin Neuropathol 1996, 15:2–6.

    Google Scholar 

  18. Puir V, Riggs G: Case report of fibromuscular dysplasia presenting as stroke in a 16-year-old boy. J Child Neurol 1999, 14:233–238.

    Article  Google Scholar 

  19. Srivastava SS, Sharma PP, Bhaumik SS, Behari MM: Fibromuscular dysplasia of internal carotid artery. Neurol India 1999, 47:77–78.

    PubMed  CAS  Google Scholar 

  20. Sandmann J, Hojer C, Bewermeyer H, et al.: Fibromuscular dysplasia as a cause of cerebral infarct. Nervenarzt 1992, 63:335–340.

    PubMed  CAS  Google Scholar 

  21. Osborn AG, Andersen RE: Angiographic spectrum of cervical and intracranial fibromuscular dysplasia. Stroke 1977, 8:617–626.

    PubMed  CAS  Google Scholar 

  22. Healton EB: Fibromuscular dysplasia. In Stroke: Pathophysiology, Diagnosis, and Management. edn 2. Edited by Barnett HJ, et al. New York, NY: Churchill Livingstone; 1986:831–843.

    Google Scholar 

  23. Puri V, Riggs G: Case report of fibromuscular dysplasia presenting as stroke in a 16 year old boy. J Child Neurol 1999, 14:233–238.

    Article  PubMed  CAS  Google Scholar 

  24. Kubis N, Von Langsdorff D, Petitjean C, et al.: Thrombotic carotid megabulb: fibromuscular dysplasia, septae, and ischemic stroke. Neurology 1999, 52:883–886.

    PubMed  CAS  Google Scholar 

  25. Houser OW, Baker HL, Sandok BA, Holley KE: Cephalic arterial fibromuscular dysplasia. Neuroradiology 1971, 101:605–611.

    CAS  Google Scholar 

  26. Rainer WG, Cramer CG, Newby JP, Clarcke JP: Fibromuscular hyperplasia of the carotid artery causing positional cerebral ischemia. Ann Surg 1968, 167:444–446.

    Article  PubMed  CAS  Google Scholar 

  27. Lipchik EO, DeWeese JA, Schenk EA, Lim GH: Diaphragm-like obstructions of the human arterial tree. Radiology 1974, 113:43–46.

    PubMed  CAS  Google Scholar 

  28. Ehrenfeld WK, Stoney RJ, Wylie EJ: Fibromuscular hyperplasia of the internal carotid artery. Arch Surg 1967, 95:284–287.

    PubMed  CAS  Google Scholar 

  29. So EL, Toole JF, Moody DM, Venkata RC: Cerebral embolism from septal fibromuscular dysplasia of the common carotid artery. Ann Neurol 1979, 6:75–78.

    Article  PubMed  CAS  Google Scholar 

  30. Wirth FP, Miller WA, Russel AP: Atypical fibromuscular hyperplasia: report of two cases. J Neurosurg 1981, 54:685–689.

    Article  PubMed  CAS  Google Scholar 

  31. Morgenlander JC, Goldstein LB: Recurrent transient ischemic attacks and stroke in association with an internal carotid artery web. Stroke 1991, 22:94–98.

    PubMed  CAS  Google Scholar 

  32. Watanabe S, Tanaka K, Nakayama T, Kaneko M: Fibromuscular dysplasia at the internal carotid origin: a case of carotid web. No Shinkei Geka 1993, 21:449–452.

    PubMed  CAS  Google Scholar 

  33. Healton EB: Cerebrovascular fibromuscular dysplasia. In Stroke: Pathophysiology, Diagnosis, and Management. Edited by Barnett HJ. New York, NY: Churchill Livingstone; 1994:749–760.

    Google Scholar 

  34. Sandok BA: Fibromuscular dysplasia of the cephalic arterial system. In Handbook of Clinical Neurology: Vascular Diseases-Part III. Edited by Toole JF. Amsterdam: Elsevier; 1989.

    Google Scholar 

  35. Sundt TM Jr: Carotid bruit audible to patient. JAMA 1991, 265:121.

    Article  PubMed  Google Scholar 

  36. Effeney DJ, Krupski WC, Stoney RJ, Ehrenfeld WK: Fibromuscular dysplasia of the carotid artery. Aust N Z J Surg 1983, 53:527–531.

    Article  PubMed  CAS  Google Scholar 

  37. Sandmann W, Schulte KM: Multivisceral fibromuscular dysplasia in childhood. Case report and review of the literature. Ann Vasc Surg 2000, 14:496–502.

    Article  PubMed  CAS  Google Scholar 

  38. Osseby G, Manceau E, Huet F, et al.: ’Fou rire prodromique’ as the heralding symptom of lenticular infarction, caused by dissection of the internal carotid artery in 12-year-old boy. Eur J Paediatr Neurol 1999, 3:133–136.

    Article  PubMed  CAS  Google Scholar 

  39. Camacho A, Villarejo A, Moreno T, et al.: Vertebral artery fibromuscular dysplasia: an unusual case of stroke in a 3-year-old child. Dev Med Child Neurol 2003, 45:709–711.

    Article  PubMed  Google Scholar 

  40. Manninen HI, Koivisto T, Saari T, et al.: Dissecting aneurysms of all four cervicocephalic arteries in fibromuscular dysplasia. Treatment with self-expanding endovascular stents, coil embolization, and surgical ligation. AJNR Am J Neuroradiol 1997, 18:1216–1220.

    PubMed  CAS  Google Scholar 

  41. Hopkins LN, Budny JL: Fibromuscular dysplasia. In Neurosurgery. Edited by Wilkins RH, Rengachary SS. New York, NY: McGraw Hill; 1985:1293–1296.

    Google Scholar 

  42. Hegedus K, Nemeth G: Fibromuscular dysplasia of the basilar artery. Case report with autopsy verification. Arch Neurol 1984, 41:440–442.

    PubMed  CAS  Google Scholar 

  43. Nomura S, Yamashita K, Kato S, et al.: Childhood subarachnoid hemorrhage associated with fibromuscular dysplasia. Childs Nerv Syst 2001, 17:419–422.

    Article  PubMed  CAS  Google Scholar 

  44. Hatayama K, Karasawa H, Naito H, et al.: Anterior cerebral artery dissecting aneurysm associated with fibromuscular dysplasia (FMD): a case report. No Shinkei Geka 2001, 29:451–456.

    PubMed  CAS  Google Scholar 

  45. Chin N-C, DeLong GR, Heinz ER: Intracranial fibromuscular dysplasia in a 5-year-old child. Pediatr Neurol 1996, 14:262–264.

    Article  Google Scholar 

  46. Romero-Lopez J, Moreno-Carretero MJ, Escriche D: Cephalic fibromuscular dysplasia and stroke in infancy: a case report and review of the literature. Rev Neurol 1996, 24:650–652.

    Google Scholar 

  47. Belen D, Bolay H, Firat M, et al.: Unusual appearance of intracranial fibromuscular dysplasia. A case report. Angiology 1996, 47:627–632.

    Article  Google Scholar 

  48. DiFazio M, Hinds SR, Depper M, et al.: Intracranial fibromuscular dysplasia in a six year old child: a rare cause of childhood stroke. J Child Neurol 2000, 15:559–562.

    Article  PubMed  CAS  Google Scholar 

  49. Zurin AA, Houkin K, Asano T, et al.: Childhood ischemic stroke caused by fibromuscular dysplasia of the intracranial artery—case report. Neurol Med Chir (Tokyo) 1997, 37:542–545.

    Article  CAS  Google Scholar 

  50. Chiras T, Bories J, Barth MO, et al.: Cerebral angiography in ischemic strokes. Neuroradiology 1985, 27:521–538.

    Article  PubMed  CAS  Google Scholar 

  51. Saver JL, Easton JD: Dissections and trauma of cervicocerebral arteries. In Stroke: Pathophysiology, Diagnosis, and Management. 3rd edn. Edited by Barnett HJ, et al. Philadelphia, PA: Churchill Livingstone; 1998:769–786.

    Google Scholar 

  52. Schievink WI, Mokri B, Piepgras DG: Spontaneous dissections of cervicocephalic arteries in childhood and adolescence. Neurology 1994, 44:1607–1612.

    PubMed  CAS  Google Scholar 

  53. Friedman WA, Day AL, Guisling RG, et al.: Cervical carotid dissecting aneurysms. Neurosurgery 1980, 7:207–214.

    Article  PubMed  CAS  Google Scholar 

  54. Schievink WI, Bjornsson J, Piepgras DG: Coexistence of fibromuscular dysplasia and cystic necrosis in a patient with Marfan’s syndrome and bilateral carotid artery dissections. Stroke 1994, 25:2492–2496.

    PubMed  CAS  Google Scholar 

  55. Mas JL, Bousser MG, Hasbourn D, Laplane D: Extracranial vertebral artery dissections. A review of 13 cases. Stroke 1987, 18:1037–1047.

    PubMed  CAS  Google Scholar 

  56. Dziewas R, Konrad C, Drager B, et al.: Cervical artery dissection —clinical features, risk factors, therapy, and outcomes in 126 patients. J Neurol 2003, 250:1179–1184. Highlighted the possible danger of chiropractic manipulation of the cervical spine. This treatment was significantly associated with bilateral vertebral artery dissection.

    Article  PubMed  Google Scholar 

  57. Duncan MA, Dowd N, Rawluk D, Cunningham AJ: Traumatic bilateral internal carotid artery dissection in a patient with fibromuscular dysplasia. Br J Anaesth 2000, 85:476–478.

    PubMed  CAS  Google Scholar 

  58. Amarenco P, Seux-Levieil ML, Cohen A, et al.: Carotid artery dissection with renal infarcts. Two cases. Stroke 1994, 25:2488–2491.

    PubMed  CAS  Google Scholar 

  59. Atkinson JL, Piepgras DG, Huston J, Mokri B: Cervical artery dissections: evidence for redissection in previously dissected arteries: report of three cases. Neurosurgery 2002, 51:797–801.

    Article  PubMed  Google Scholar 

  60. Rhee RY, Gloviczki P, Cherry KJ Jr, Edwards WD: Two unusual variants of internal carotid artery aneurysms due to fibromuscular dysplasia. Ann Vasc Surg 1996, 10:481–485.

    Article  Google Scholar 

  61. Hinse P, Thie A, Lachenmayer L: Dissection of the extracranial vertebral artery: report of four cases and review of the literature. J Neurol Neurosurg Psychiatry 1991, 54:863–869.

    Article  PubMed  CAS  Google Scholar 

  62. Mokri B: Traumatic and spontaneous extracranial internal carotid artery dissections. J Neurol 1990, 237:356–361.

    Article  PubMed  CAS  Google Scholar 

  63. Rodacki MA, Mello LR: Bilateral dissecting aneurysms of the extracranial vertebral arteries associated with cervical carotid artery aneurysm. AJNR Am J Neuroradiol 1990, 11:1147–1149.

    PubMed  CAS  Google Scholar 

  64. Cloft HJ, Kallmes DF, Kallmes MH, et al.: Prevalence of cerebral aneurysms in patients with fibromuscular dysplasia: a reassessment. J Neurosurg 1998, 88:436–440.

    Article  PubMed  CAS  Google Scholar 

  65. Hernesniemi JA, Drake CG, Peerless SJ: Nongiant aneurysms of the vertebral artery. In Surgery of Vertebrobasilar Aneurysms: London, Ontario Experience on 1767 Patients. Edited by Drake CG, et al. Vienna, Austria: Springer; 1996:195–206.

    Google Scholar 

  66. Miyauchi M, Shionoya S: Aneurysm of the extracranial internal carotid artery caused by fibromuscular dysplasia. Eur J Vasc Surg 1991, 5:587–591.

    Article  PubMed  CAS  Google Scholar 

  67. Bour P, Taghavi I, Bracard S, et al.: Aneurysms of the extracranial internal carotid artery due to fibromuscular dysplasia: results of surgical management. Ann Vasc Surg 1992, 6:205–208.

    Article  PubMed  CAS  Google Scholar 

  68. Mandai S, Nishino S, Itoh T, et al.: A case of fibromuscular dysplasia associated with intra and extra-cranial multiple aneurysms. No Shinkei Geka 1992, 20:611–615.

    PubMed  CAS  Google Scholar 

  69. Bellot J, Gerardi R, Poirer J, et al.: Fibromuscular dysplasia of cervico-cephalic arteries with multiple dissections and a carotid-cavernous fistula. Stroke 1985, 16:255–261.

    PubMed  CAS  Google Scholar 

  70. Hirai T, Korogi Y, Goto K, et al.: Carotid-cavernous sinus fistula and aneurismal rupture associated with fibromuscular dysplasia. A case report. Acta Radiol 1996, 37:49–51.

    Article  Google Scholar 

  71. Caplan LR: Nonatherosclerotic vasculopathies. In Caplan’s Stroke: A Clinical Approach, 3rd edn. Edited by Caplan LR. Boston, MA: Butterworth-Heinemann; 2000:295–342.

    Google Scholar 

  72. DeVries RR, Nikkels PG, van der Laag J, et al.: Moyamoya and extracranial vascular involvement: fibromuscular dysplasia? A report of two children. Neuropediatrics 2003, 34:318–321.

    Article  CAS  Google Scholar 

  73. Begue P, Faure C, Rousseau MC, et al.: Cerebrovascular accidents in children with homozygous sickle cell anemia: report on three cases. Ann Med Intern 1981, 132:190–194.

    CAS  Google Scholar 

  74. Escamilla F, Espigares A, Hervas R, et al.: Fibromuscular dysplasia with moyamoya phenomenon in a patient with Alport’s syndrome. A type IV collagen disorder. Rev Neurol 2000, 30:736–740.

    PubMed  CAS  Google Scholar 

  75. Nozaki Y, Mizuguchi M, Momoi MY: A boy with infantileonset fibromuscular dysplasia showing recurrent cerebrovascular attacks. No To Hattasu 2003, 35:253–258.

    Google Scholar 

  76. Verdu Perez A, Rinaudo Zaniratto R, Perez-Higueras A: The moyamoya syndrome secondary to fibromuscular dysplasia of the middle cerebral artery. An Esp Pediatr 1996, 45:99–100.

    Google Scholar 

  77. Boespflug OJ: Ultrasonography of supra-aortic trunks. Neuroradiology 1985, 27:544–547.

    Article  PubMed  CAS  Google Scholar 

  78. Arning C: Nonatheromatous disease of the cervical arteries: role of ultrasonography for diagnosis. Vasa 2001, 30:160–167. In cases of FMD, ultrasound has delivered less positive results on account of the unfavorable localization for duplex sonography. Because the disease has a relatively good prognosis, only symptomatic cases need be detected. Overall, sonography is a suitable method for the diagnosis of nonatherosclerotic disease of the cervical arteries.

    Article  PubMed  CAS  Google Scholar 

  79. Boutouyrie P, Gimenez-Roqueplo AP, Fine E, et al.: Evidence for carotid and radial artery wall subclinical lesions in renal fibromuscular dysplasia. J Hypertens 2003, 21:2287–2295. Described a new carotid phenotype in patients with FMD using a noninvasive echotracking sytem. The data suggest that renal FMD is not a focal but a systemic arterial disease.

    Article  PubMed  CAS  Google Scholar 

  80. Heiserman JE, Drayer BP, Fram EK, Keller PJ: MR angiography of cervical fibromuscular dysplasia. AJNR Am J Neuroradiol 1992, 13:1454–1457.

    PubMed  CAS  Google Scholar 

  81. Weissman JL, Hirsch BE: Imaging of tinnitus, a review. Radiology 2000, 216:342–349.

    PubMed  CAS  Google Scholar 

  82. Link J, Steffens JC, Muller-Hulsbeck S, et al.: MR angiography in fibromuscular dysplasia of the cervical arteries. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 1996, 164:201–205.

    Article  Google Scholar 

  83. Wolpert SM, Caplan LR: Current role of cerebral angiography in the diagnosis of cerebrovascular diseases. Am J Roentgenol 1992, 159:191–197.

    CAS  Google Scholar 

  84. Phadke RV, Taori KB, Diveker VK: Fibromuscular dysplasia of common carotid artery: a case report. Australas Radiol 1990, 34:350–352.

    Article  PubMed  CAS  Google Scholar 

  85. Russo CP, Smoker WR: Nonatheromatous carotid artery disease. Neuroimaging Clin N Am 1996, 6:811–830.

    Google Scholar 

  86. Sang CN, Whelton PK, Hamper UM, et al.: Etiologic factors in renovascular fibromuscular dysplasia: a case-control study. Hypertension 1989, 14:472–479.

    PubMed  CAS  Google Scholar 

  87. Rushton AR: The genetics of fibromuscular dysplasia. Arch Intern Med 1980, 140:233–236.

    Article  PubMed  CAS  Google Scholar 

  88. Bigazzi R, Bianchi S, Quilici N, et al.: Bilateral fibromuscular dysplasia in identical twins. Am J Kidney Dis 1998, 32:E4.

    Article  PubMed  CAS  Google Scholar 

  89. Grange DK, Balfour IC, Chen SC, Wood EG: Familial syndrome of progressive arterial occlusive disease consistent with fibromuscular dysplasia, hypertension, congenital cardiac defects bone fragility, brachysyndactyly, and learning disabilities. Am J Med Genet 1998, 75:469–480.

    Article  PubMed  CAS  Google Scholar 

  90. Petit H, Bouchez B, Destee A, Clarisse J: Familial form of fibromuscular dysplasia of the internal carotid artery. J Neuroradiol 1983, 10:15–22.

    PubMed  CAS  Google Scholar 

  91. Mokri B, Piepgras DG, Wiebers DO, Houser OW: Familial occurrence of spontaneous dissection of the internal carotid artery. Stroke 1987, 18:246–251.

    PubMed  CAS  Google Scholar 

  92. Perez Errazquin F, Gil Peralta A, Garzon FJ, et al.: Familial internal carotid dissection. Neurologia 1998, 13:247–249.

    PubMed  CAS  Google Scholar 

  93. Pannier-Moreau I, Grimbert P, Fiquet-Kempf B, et al.: Possible familial origin of multifocal renal artery fibromuscular dysplasia. J Hypertens 1997, 15:1797–1801.

    Article  PubMed  CAS  Google Scholar 

  94. Schievink WI, Prakash UBS, Piepgras DG, Mokri B: Alpha1-antitrypsin deficiency in intracranial aneurysms and cervical artery dissection. Lancet 1994, 343:452–453.

    Article  PubMed  CAS  Google Scholar 

  95. Imaya H, Kobayashi S, Okada T, et al.: A case of fibromuscular dysplasia with middle cerebral aneurysm. No Shinkei Geka 1985, 13:653–658.

    PubMed  CAS  Google Scholar 

  96. Schievink WI, Bjornsson J, Parisi JE, Prakash UB: Arterial fibromuscular dysplasia associated with severe alpha1-antitrypsin deficiency. Mayo Clin Proc 1994, 69:1040–1043.

    PubMed  CAS  Google Scholar 

  97. Schievink WI, Puumala MR, Meyer FB, et al.: Giant intracranial aneurysm and fibromuscular dysplasia in an adolescent with alpha1-antitrypsin deficiency. J Neurosurg 1996, 85:503–506.

    Google Scholar 

  98. Schievink WI, Katzmann JA, Piepgras DG: Alpha-1-antitrypsin deficiency in spontaneous intracranial arterial dissections. Cerebrovasc Dis 1998, 8:42–44.

    Article  PubMed  CAS  Google Scholar 

  99. Solder B, Streif W, Ellemunter H, et al.: Fibromuscular dysplasia of the internal carotid artery in a child with alpha-1-antitrypsin deficiency. Dev Med Child Neurol 1997, 39:827–829.

    Article  PubMed  CAS  Google Scholar 

  100. Bernstein PR, Edwards PD, Williams JC: Inhibitors of human leukocyte elastase. Prog Med Chem 1994, 31:59–120.

    Article  PubMed  CAS  Google Scholar 

  101. Cox DW: Alpha1-antitrypsin deficiency. In The Metabolic and Molecular Bases of Inherited Disease. Edited by Scriver CR, et al. New York, NY: McGraw Hill; 1995:4125–4158.

    Google Scholar 

  102. Cox DW: Alpha1-antitrypsin: a guardian of vascular tissue. Mayo Clin Proc 1994, 69:1123–1124.

    PubMed  CAS  Google Scholar 

  103. Lancman M, Mesropian H, Serra P, Granillo R: Turner’s syndrome, fibromuscular dysplasia, and stroke. Stroke 1991, 22:269–271.

    PubMed  CAS  Google Scholar 

  104. Miyake S, Arai J, Hayashi M, et al.: A case of Turner syndrome with renal hypertension: fibromuscular dysplasia in cerebro-renal arteries. No To Hattatsu 1985, 17:438–442.

    PubMed  CAS  Google Scholar 

  105. Fievez M, Koerperich G, Dulieu J: Arterial fibromuscular dysplasia and ergotism [in French]. Ann Anat Pathol (Paris) 1975, 20:357–366.

    CAS  Google Scholar 

  106. Fievez ML: Fibromuscular dysplasia of arteries: a spastic phenomenon? Med Hypotheses 1984, 13:341–349.

    Article  PubMed  CAS  Google Scholar 

  107. Bofinger A, Hawley C, Fisher P, et al.: Increased severity of multifocal renal artery fibromuscular dysplasia in smokers. J Hum Hypertens 1999, 13:517–520.

    Article  PubMed  CAS  Google Scholar 

  108. Galanski M, Hofmann P: Multiple vascular stenoses in neurofibromatosis. Radiologe 1977, 17:83–89.

    PubMed  CAS  Google Scholar 

  109. Schievink WI, Limburg M: Angiographic abnormalities mimicking fibromuscular dysplasia in a patient with Ehlers-Danlos syndrome, type IV. Neurosurgery 1989, 25:482–508.

    Article  PubMed  CAS  Google Scholar 

  110. Sanchez Torres G, Contreras R: Fibromuscular dysplasia: a genetic entity related to Ehlers-Danlos syndrome. Arch Inst Cardiol Mex 1974, 44:571–581.

    PubMed  CAS  Google Scholar 

  111. Mitsias P, Levine SR: Large cerebral vessel occlusive disease in systemic lupus erythematosus. Neurology 1994, 44:385–393.

    PubMed  CAS  Google Scholar 

  112. Yoshimoto T, Ueno K, Ihara T, et al.: A case of systemic lupus erythematosus with neurological manifestations as initial symptoms. No Shinkei Geka 1989, 17:489–493.

    PubMed  CAS  Google Scholar 

  113. Szpak GM, Kuczynska-Zardzewialy A, Popow J: Brain vascular changes in the case of primary antiphospholipid syndrome. Folia Neuropathol 1996, 34:92–96.

    Google Scholar 

  114. Tripathyi M, Santosh V, Nagaraj D, et al.: Stroke in a young man with fibromuscular dysplasia of the cranial vessels with anticardiolipin antibodies: a case report. Neurol Sci 2001, 22:31–35.

    Article  Google Scholar 

  115. Buttinelli C, Spalloni A, Fieschi C, Rasura M: Migraine and arterial dissection an a young woman. Neurol Sci 2001, 22:275–278.

    Article  PubMed  CAS  Google Scholar 

  116. Shi FY: Morphological studies of extracranial arteries in patients with migraine. Zhonghua Bing Li Xue Za Zhi 1989, 18:271–273.

    PubMed  CAS  Google Scholar 

  117. Moreau P, Albat B, Thevenet A: Fibromuscular dysplasia of the internal carotid artery: long-term surgical results. J Cardiovasc Surg 1993, 34:465–472.

    CAS  Google Scholar 

  118. Ballard JL, Guinn JE, Kileen JD, Smith DC: Open operative balloon angioplasty of the internal carotid artery: a technique in evolution. Ann Vasc Surg 1995, 9:390–393.

    Article  PubMed  CAS  Google Scholar 

  119. Smith DC, Smith LL, Hasso AN: Fibromuscular dysplasia of the internal carotid artery treated by operative transluminal balloon angioplasty. Radiology 1985, 155:645–648.

    PubMed  CAS  Google Scholar 

  120. Balaji MR, DeWeese JA: Fibromuscular dysplasia of the internal carotid artery: Its occurrence with acute stroke and its surgical reversal. Arch Surg 1980, 115:984–986.

    PubMed  CAS  Google Scholar 

  121. Collins GJ Jr, Rich NM, Clagett GP, et al.: Fibromuscular dysplasia of the internal carotid arteries. Clinical experience and follow-up. Ann Surg 1981, 194:89–96.

    Article  PubMed  Google Scholar 

  122. Welsh P, Prdier R, Repetto R: Fibromuscular dysplasia of the distal cervical internal carotid artery. J Cardiovasc Surg 1981, 22:321–326.

    CAS  Google Scholar 

  123. De Smul G, Bostoen H: Operative balloon dilatation of fibromuscular dysplasia of the internal carotid artery: two case reports. Acta Chir Belg 1995, 95:139–143.

    PubMed  Google Scholar 

  124. Van Damme H, Sakalihasan N, Limet R: Fibromuscular dysplasia of the internal carotid artery. Personal experience with 13 cases and literature review. Acta Chir Belg 1999, 99:163–168.

    PubMed  Google Scholar 

  125. Stewart MT, Moritz MW, Smith RB 3rd, et al.: The natural history of carotid fibromuscular dysplasia. J Vasc Surg 1986, 3:305–310.

    Article  PubMed  CAS  Google Scholar 

  126. Hasso AN, Bird CR, Zinke DE, Thompson JR: Fibromuscular dysplasia of the internal carotid artery: percutaneous transluminal angioplasty. Am J Roentgenol 1981, 136:955–960.

    CAS  Google Scholar 

  127. Finsterer J, Strassegger J, Haymerle A, Hagmuller G: Bilateral stenting of symptomatic and asymptomatic internal carotid artery stenosis due to fibromuscular dysplasia. J Neurol Neurosurg Psychiatry 2000, 69:683–686.

    Article  PubMed  CAS  Google Scholar 

  128. Wilms GE, Smits J, Baert AL, De Wolf L: Percutaneous transluminal angioplasty in fibromuscular dysplasia of the internal carotid artery: one year clinical and morphological follow-up. Cardiovasc Intervent Radiol 1985, 8:20–23.

    Article  PubMed  CAS  Google Scholar 

  129. Takigami M, Baba T, Saitou K: Percutaneous transluminal angioplasty in fibromuscular dysplasia of the internal carotid artery: case report. No Shinkei Geka 2002, 30:301–306.

    PubMed  Google Scholar 

  130. Kubaska SM 3rd, Greenberg RK, Clair D, et al.: Internal carotid artery pseudoaneurysms: treatment with the Wallgraft endoprosthesis. J Endovasc Ther 2003, 10:182–189.

    Article  PubMed  Google Scholar 

  131. Curry TK, Messina LM: Fibromuscular dysplasia: when is intervention warranted? Semin Vasc Surg 2003, 16:190–199.

    Article  PubMed  Google Scholar 

  132. Sandok BA: Fibromuscular dysplasia of the internal carotid artery. In Neurological Clinics, vol 1. Edited by Barnett HJ. Philadelphia, PA: WB Saunders; 1983:17–26.

    Google Scholar 

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Leary, M.C., Finley, A. & Caplan, L.R. Cerebrovascular complications of fibromuscular dysplasia. Curr Treat Options Cardiovasc Med 6, 237–248 (2004). https://doi.org/10.1007/s11936-996-0019-5

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