Opinion statement
Our brain regulates all bodily functions either directly or indirectly, and cardiovascular control is no exception. There is strong clinical evidence of cerebrogenic cardiac arrhythmias and myocardial changes during ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage. Alternative scenarios include cardioembolic stroke, multisystem diseases with stroke-like and cardiac features, and coincidental detection of cardiac disorders in a stroke patient. Cardiac effects of stroke may be severe or even fatal and worsen the prognosis. Clinical and experimental studies suggest that cortical and subcortical structures such as the insular cortex and amygdala play a pathogenic role. The peripheral mechanisms involve abnormal sympathetic activity, altered parasympathetic activity, and raised levels of circulating catecholamines, whereas the central mechanisms are largely unknown. Because stroke patients are best managed in an acute stroke unit during their initial presentation, a cardiocerebral approach is desirable with close cardiovascular and neurologic monitoring. Prolonged and intensive cardiovascular monitoring is recommended in patients manifesting cerebrogenic cardiovascular disturbances and in high-risk patients with insular involvement, rightsided stroke, advancing age, coexisting hypertensive or coronary artery disease, or intense emotional stress. Although the best management is largely unknown, treatment of cardiac effects of stroke is largely supportive according to the type of disturbance. Severely affected patients should be evaluated by a cardiologist prior to the initiation of appropriate therapy. Much more clinical and basic research is needed to allow a full understanding of the brain-heart control, the consequences of disruption of this control, the true incidence of cardiac effects of stroke, and the evidence-based treatment options.
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References and Recommended Reading
Cheung RTF: The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion. J Pineal Res 2003, 34:153–160.
Cheung RTF, Hachinski V: Cardiology. In Hospitalist Neurology (Blue Books of Practical Neurology, vol 19). Edited by Samuels MA. Boston: Butterworth-Heinemann Medical; 1999:305–330.
Cheung RTF, Hachinski V: Cardiac rhythm disorders and muscle changes with cerebral lesions. Adv Neurol 2003, 92:213–220. An excellent and recent summary of current issues and published reports of the cardiac arrhythmias and myocardial changes seen in some common or important causes of cerebral lesion, with an outline on the plausible peripheral and central neuroanatomical basis and neurochemical mediators of cerebrogenic arrhythmias and cardiomyopathy.
Cheung RTF, Hachinski V: The insula and cerebrogenic sudden death. Arch Neurol 2000, 57:1685–1688. recent review of available evidence on the role of the insular cortex on cerebrogenic sudden death, as well as nonfatal cerebrogenic cardiovascular disturbances.
Adams HP Jr, Adams RJ, Brott T, et al.: Guidelines for the early management of patients with ischemic stroke. A scientific statement from the Stroke Council of the American Stroke Association. Stroke 2003, 34:1056–1083.
Bertinchant JP, Robert E, Polge A, et al.: Comparison of the diagnostic value of cardiac troponin I and T determinations for detecting early myocardial damage and the relationship with histological findings after isoprenaline-induced cardiac injury in rats. Clin Chim Acta 2000, 298:13–28.
James P, Ellis CJ, Whitlock RM, et al.: Relation between troponin T concentration and mortality in patients presenting with an acute stroke: observational study. BMJ 2000, 320:1502–1504.
Ay H, Arsava EM, Saribas O: Creatine kinase-MB elevation after stroke is not cardiac in origin. Comparison with troponin T levels. Stroke 2002, 33:286–289.
Sander D, Klingelhöfer J: Changes of circadian blood pressure patterns after hemodynamic and thromboembolic brain infarction. Stroke 1994, 25:1730–1737.
Sander D, Klingelhöfer J: Stroke-associated pathological sympathetic activation related to size of infarction and extent of insular damage. Cerebrovasc Dis 1995, 5:381–385.
Klingelhöfer J, Sander D: Cardiovascular consequences of clinical stroke. Baillieres Clin Neurol 1997, 6:309–335.
Sander D, Winbeck K, Klingelhöfer J, et al.: Prognostic relevance of pathological sympathetic activation after acute thromboembolic stroke. Neurology 2001, 57:833–838.
Tokgözoglu SL, Batur MK, Topçuoglu MA, et al.: Effects of stroke localization on cardiac autonomic balance and sudden death. Stroke 1999, 30:1307–1311.
Korpelainen JT, Sotaniemi KA, Mäkikallio A, et al.: Dynamic behavior of heart rate in ischemic stroke. Stroke 1999, 30:1008–1013.
Megli_ B, Kobal J, Osredkar J, Poga_nik T: Autonomic nervous system function in patients with acute brainstem stroke. Cerebrovasc Dis 2001, 11:2–8.
Oppenheimer SM: Management of cardiac/ECG complications of stroke. In Primer on Cerebrovascular Diseases. Edited by Welch K, et al. New York: Academic Press; 1997:692–696.
Erciyas AH, Topalkara K, Topaktas S, et al.: Suppression of cardiac parasympathetic functions in patients with right hemispheric stroke. Eur J Neurol 1999, 6:685–690.
Blomström-Lundqvist, Scheinman MM, Aliot EM, et al.: ACC/AHA/ESC Guidelines for the management of patients with supraventricular arrhythmias—executive summary. A report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (writing committee to develop guidelines for the management of patients with supraventricular arrhythmias). J Am Coll Cardiol 2003, 42:1493–1531.
McNamara RL, Tamartz LJ, Segal JB, Bass EB: Management of atrial fibrillation: review of the evidence for the role of pharmacologic therapy, electrical cardioversion, and echocardiography. Ann Intern Med 2003, 139:1018–1033.
Fischer A, Verma R, Gomes JA, Mehta D: Ventricular arrhythmia: role of the implantable cardioverter defibrillator and radiofrequency ablation in addition to drugs. Mount Sinai J Med 2002, 69:197–207.
Mayberg MR, Batjer HH, Dacey R, et al.: Guidelines for management of aneurysmal subarachnoid hemorrhage. A statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Stroke 1994, 25:2315–2328.
Broderick JP, Adams HP Jr, Barsan W, et al.: Guidelines for the management of spontaneous intracerebral hemorrhage. Stroke 1999, 30:905–915.
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Cheung, R.T.F., Hachinski, V. Cardiac effects of stroke. Curr Treat Options Cardiovasc Med 6, 199–207 (2004). https://doi.org/10.1007/s11936-996-0014-x
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DOI: https://doi.org/10.1007/s11936-996-0014-x