Cardiovascular Concerns in BRCA1 and BRCA2 Mutation Carriers

  • Kelly C. Gast
  • Paul V. Viscuse
  • Somaira Nowsheen
  • Tufia C. Haddad
  • Robert W. Mutter
  • Andrea E. Wahner Hendrickson
  • Fergus J. Couch
  • Kathryn J. Ruddy
Cardio-oncology (M Fradley, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Cardio-oncology


Purpose of review

BRCA1 and BRCA2 mutation carriers can be at increased cardiovascular risk. The goal of this review is to provide information about factors associated with increased cardiovascular risk, methods to prevent cardiovascular toxicities, and recommended screening guidelines.

Recent findings

BRCA1/2 mutation carriers who are diagnosed with cancer are often exposed to chemotherapy, chest radiotherapy, and/or HER2 directed therapies, all of which can be cardiotoxic. In addition, BRCA1/2 carriers often undergo prophylactic salpingoopherectomies, which may also increase cardiovascular risks.


Understanding the potential for increased cardiovascular risk in individuals with a BRCA1 or BRCA2 mutation, as well as gold standard practices for prevention, detection, and treatment of cardiac concerns in this population, is important.


BRCA mutation Cardio-oncology Chemotherapy cardiotoxicity Radiation cardiotoxicity 


Compliance with Ethical Standards

Conflict of Interest

Kelly C. Gast, Paul V. Viscuse, Somaira Nowsheen, Tufia C. Haddad, Robert W. Mutter, Andrea E. Wahner Hendrickson, and Kathryn J. Ruddy each declare no potential conflicts of interest. Fergus J. Couch reports research funding to the institution from GRAIL Inc.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Kelly C. Gast
    • 1
  • Paul V. Viscuse
    • 1
  • Somaira Nowsheen
    • 2
  • Tufia C. Haddad
    • 3
  • Robert W. Mutter
    • 4
  • Andrea E. Wahner Hendrickson
    • 3
  • Fergus J. Couch
    • 5
  • Kathryn J. Ruddy
    • 3
  1. 1.Department of Internal MedicineMayo Clinic School of Graduate Medical EducationRochesterUSA
  2. 2.Mayo Clinic Graduate School of Biomedical SciencesMedical Scientist Training Program, Mayo Clinic School of MedicineRochesterUSA
  3. 3.Department of Oncology, Division of Medical OncologyMayo ClinicRochesterUSA
  4. 4.Department of Radiation OncologyMayo ClinicRochesterUSA
  5. 5.Department of Laboratory Medicine and PathologyMayo ClinicRochesterUSA

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