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Treatment of venous thrombosis at unusual sites

Opinion statement

The literature is filled with randomized controlled trial data to guide most steps in managing patients with deep venous thrombosis of the extremities or pulmonary embolism. Venous thrombosis, however, is not limited to these locations and may involve the cerebral venous sinuses, renal veins, splanchnic veins, and ovarian veins. The causes of these thrombi are often unique to the venous segments involved and typically stem from pathologies of the organs supplied by these veins. Very little randomized controlled trial data exist to guide therapy for these atypical venous thrombi. Treatment should focus on correcting the underlying disease and relieving venous congestion of the involved organ while preserving organ functionality. Although natural history data are limited, recurrence rates for these atypical venous thrombi appear to be relatively low. Indefinite secondary anticoagulant prophylaxis is therefore primarily dictated by the congenital or acquired pathology precipitating the event.

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References and Recommended Reading

  1. Heit JA, O’Fallon WM, Petterson TM, et al.: Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study. Arch Intern Med 2002, 162:1245–1248.

    PubMed  Article  Google Scholar 

  2. Silverstein MD, Heit JA, Mohr DN, et al.: Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med 1998, 158:585–593.

    PubMed  Article  CAS  Google Scholar 

  3. Heit JA, Silverstein MD, Mohr DN, et al.: Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Arch Intern Med 2000, 160:809–815.

    PubMed  Article  CAS  Google Scholar 

  4. Geerts WH, Pineo GF, Heit JA, et al.: Prevention of venous thromboembolism: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004, 126:338S–400S.

    PubMed  Article  CAS  Google Scholar 

  5. Büller HR, Agnelli G, Hull RD, et al.: Antithrombotic therapy for venous thromboembolic disease: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004, 126:401S–428S.

    PubMed  Article  Google Scholar 

  6. Wysokinski WE, Gosk-Bierska I, Karnicki K, McBane RD: Etiology and natural history of venous thrombosis of atypical location. Phlebologie 2005, 58:275–287.

    Google Scholar 

  7. Gosk-Bierska I, Wysokinski WE, Brown RD Jr, et al.: Natural history of cerebral venous sinus thrombosis: incidence of recurrent venous thromboembolism and survival. Neurology 2006, 67:814–819.

    PubMed  Article  CAS  Google Scholar 

  8. Lin A, Foroozan R, Danesh-Meyer HV, et al.: Occurrence of cerebral venous sinus thrombosis in patients with presumed idiopathic intracranial hypertension. Ophthalmology 2006, 113:2281–2284.

    PubMed  Article  Google Scholar 

  9. Ferro JM, Canhão P, Bousser MG, et al.: ISCVT Investigators: Cerebral vein and dural sinus thrombosis in elderly patients. Stroke 2005, 36:1927–1932.

    PubMed  Article  Google Scholar 

  10. Einhaupl KM, Villringer A, Meister W, et al.: Heparin treatment in sinus venous thrombosis. Lancet 1991, 338:597–600.

    PubMed  Article  CAS  Google Scholar 

  11. de Bruijn S, Stam J: Randomized placebo controlled trial of anticoagulant treatment with low molecular weight heparin for cerebral sinus thrombosis. Stroke 1999, 30:484–488.

    PubMed  Google Scholar 

  12. Rondepierre P, Hamon M, Leys D, et al.: Thromboses veineuses cerebrales; etude de l’evolution. Rev Neurol (Paris) 1995, 151:100–104.

    CAS  Google Scholar 

  13. Cakmak S, Derex L, Berruyer M, et al.: Cerebral venous thombosis: clinical outcome and systematic screening of prothrombotic factors. Neurology 2003, 60:1175–1178.

    PubMed  CAS  Google Scholar 

  14. Ferro JM, Canhão P, Stam J, et al.: ISCVT Investigators: Prognosis of cerebral vein and dural sinus thrombosis. Stroke 2004, 35:664–670.

    PubMed  Article  Google Scholar 

  15. Girot M, Ferro JM, Canhão P, et al.: ISCVT Investigators: Predictors of outcome in patients with cerebral venous thrombosis and intracranial hemorrhage. Stroke 2007, 38:337–342.

    PubMed  Article  Google Scholar 

  16. McCarthy LJ, Titus JL, Daugherty GW: Bilateral renal vein thrombosis and the nephrotic syndrome in adults. Ann Intern Med 1963, 58:837–849.

    PubMed  CAS  Google Scholar 

  17. Zucchelli P: Renal vein thrombosis. Nephrol Dial Transplant 1992, 7(Suppl 1):105–108.

    PubMed  Google Scholar 

  18. Velasquez Forero F, Garcia Prugue N, Ruiz Morales N: Idiopathic nephrotic syndrome of the adult with asymptomatic thrombosis of the renal vein. Am J Nephrol 1988, 8:457–462.

    PubMed  CAS  Article  Google Scholar 

  19. Wysokinski WE, Gosk-Bierska I, Greene EL, et al.: Clinical characteristics and long-term follow-up of patients with renal vein thrombosis. Am J Kidney Dis 2007, In press.

  20. Webster GJM, Burroughs AK, Riordan SM: Portal vein thrombosis—new insights into etiology and management. Aliment Pharmacol Ther 2005, 21:1–9.

    PubMed  Article  CAS  Google Scholar 

  21. Ogren M, Bergqvist D, Wahlander K, et al.: Trousseau’s syndrome—what is the evidence? A population-based autopsy study. Thromb Haemost 2006, 95:541–545.

    PubMed  Google Scholar 

  22. Okuda K, Ohnishi K, Kimura K, et al.: Incidence of portal vein thrombosis in liver cirrhosis. An angiographic study in 708 patients. Gastroenterology 1985, 89:279–286.

    PubMed  CAS  Google Scholar 

  23. Condat B, Pessione F, Hillaire S, et al.: Current outcome of portal vein thrombosis in adults: risk and benefit of anticoagulant therapy. Gastroenterology 2001, 120:490–497.

    PubMed  Article  CAS  Google Scholar 

  24. Schafer C, Zundler J, Bode JC: Thrombolytic therapy in patients with portal vein thrombosis: case report and review of the literature. Eur J Gastroenterol Hepatol 2000, 12:1141–1145.

    PubMed  CAS  Google Scholar 

  25. Henao EA, Bohannon WT, Silva MB Jr: Treatment of portal venous thrombosis with selective superior mesenteric artery infusion of recombinant tissue plasminogen activator. J Vasc Surg 2003, 38:1411–1415.

    PubMed  Article  CAS  Google Scholar 

  26. Aytekin C, Boyvat F, Kurt A, et al.: Catheter-directed thrombolysis with transjugular access in portal vein thrombosis secondary to pancreatitis. Eur J Radiol 2001, 39:80–82.

    PubMed  Article  CAS  Google Scholar 

  27. Lopera JE, Correa G, Brazzini A, et al.: Percutaneous transhepatic treatment of symptomatic mesenteric venous thrombosis. J Vasc Surg 2002, 36:1058–1061.

    PubMed  Article  Google Scholar 

  28. Liatsos C, Vlachogiannakos J, Patch D, et al.: Successful recanalization of portal vein thrombosis before liver transplantation using transjugular intrahepatic portosystemic shunt. Liver Transpl 2001, 7:453–460.

    PubMed  Article  CAS  Google Scholar 

  29. Janssen HL, Wijnhoud A, Haagsma EB, et al.: Extrahepatic portal vein thrombosis: aetiology and determinants of survival. Gut 2001, 49:720–724.

    PubMed  Article  CAS  Google Scholar 

  30. Rhee RY, Gloviczki P, Mendonca CT, et al.: Mesenteric venous thrombosis: still a lethal disease in the 1990s. J Vasc Surg 1994, 20:688–697.

    PubMed  CAS  Google Scholar 

  31. Grendell JH, Ockner RK: Mesenteric venous thrombosis. Gastroenterology 1982, 82:358–372.

    PubMed  CAS  Google Scholar 

  32. Kumar S, Kamath PS: Acute superior mesenteric venous thrombosis: one disease or two? Am J Gastroenterol 2003, 98:1299–1304.

    PubMed  Article  Google Scholar 

  33. Reinus JF, Brandt LJ, Boley SJ: Ischemic diseases of the bowel. Gastroenterol Clin North Am 1990, 19:319–343.

    PubMed  CAS  Google Scholar 

  34. Naitove A, Weismann RE: Primary mesenteric venous thrombosis. Ann Surg 1965, 161:516–523.

    PubMed  Article  CAS  Google Scholar 

  35. Abdu RA, Zakhour BJ, Dallas DJ: Mesenteric venous thrombosis 1911 to 1984. Surgery 1987, 101:383–388.

    PubMed  CAS  Google Scholar 

  36. Mathews JE, White RR: Primary mesenteric venous occlusive disease. Am J Surg 1971, 122:579–583.

    PubMed  Article  CAS  Google Scholar 

  37. Morasch MD, Ebaugh JL, Chiou AC, et al.: Mesenteric venous thrombosis: a changing clinical entity. J Vasc Surg 2001, 34:680–684.

    PubMed  Article  CAS  Google Scholar 

  38. Rhee RY, Gloviczki P: Mesenteric venous thrombosis. Surg Clin North Am 1997, 77:327–338.

    PubMed  Article  CAS  Google Scholar 

  39. Poplausky MR, Kaufman JA, Geller SC, Waltman AC: Mesenteric venous thrombosis treated with urokinase via the superior mesenteric artery. Gastroenterology 1996, 110:1633–1635.

    PubMed  Article  CAS  Google Scholar 

  40. Yankes JR, Uglietta JP, Grant J, Braun SD: Percutaneous transhepatic recanalization and thrombolysis of the superior mesenteric vein. AJR Am J Roentgenol 1991, 151:289–290.

    Google Scholar 

  41. Rivitz SM, Geller SC, Hahn C, Waltman AC: Treatment of acute mesenteric venous thrombosis with transjugular intramesenteric urokinase infusion. J Vasc Interv Radiol 1995, 6:219–228.

    PubMed  CAS  Google Scholar 

  42. Train JS, Ross H, Weiss JD, et al.: Mesenteric venous thrombosis: successful treatment by intraarterial lytic therapy. J Vasc Interv Radiol 1998, 9:461–464.

    PubMed  CAS  Google Scholar 

  43. Lopera JE, Correa G, Brazzini A, et al.: Percutaneous transhepatic treatment of symptomatic mesenteric venous thrombosis. J Vasc Surg 2002, 36:1058–1061.

    PubMed  Article  Google Scholar 

  44. Pavel J, Levy MM, Krausz JM: The role of second-look procedure in improving survival time for patients with mesenteric vein thrombosis. Surg Gynecol Obstet 1990, 170:287–291.

    Google Scholar 

  45. Inahara T: Acute superior mesenteric venous thrombosis: treatment by thrombectomy. Ann Surg 1971, 174:956–961.

    PubMed  Article  CAS  Google Scholar 

  46. Evans GR, Yellin AE, Weaver FA, Stain SC: Sinistral (leftsided) portal hypertension. Am Surg 1990, 56:758–763.

    PubMed  CAS  Google Scholar 

  47. Sakorafas GH, Tsiotou AG: Splenic-vein thrombosis complicating chronic pancreatitis. Scand J Gastroenterol 1999, 34:1171–1177.

    PubMed  Article  CAS  Google Scholar 

  48. Weber SM, Rikkers LF: Splenic vein thrombosis and gastrointestinal bleeding in chronic pancreatitis. World J Surg 2003, 27:1271–1274.

    PubMed  Article  Google Scholar 

  49. Pietrabissa A, Moretto C, Antonelli G, et al.: Thrombosis in the portal venous system after elective laparoscopic splenectomy. Surg Endosc 2004, 18:1140–1143.

    PubMed  Article  CAS  Google Scholar 

  50. Menon KV, Shah V, Kamath PS: The Budd-Chiari syndrome. N Engl J Med 2004, 350:578–585.

    PubMed  Article  CAS  Google Scholar 

  51. Valla DC: Prognosis in Budd Chiari syndrome after re-establishing hepatic venous drainage. Gut 2006, 55:761–763.

    PubMed  Article  Google Scholar 

  52. Kamath PS: Budd-Chiari syndrome: radiologic findings. Liver Transpl 2006, 12:S21–S22.

    PubMed  Article  Google Scholar 

  53. Hadengue A, Poliquin M, Vilgrain V, et al.: The changing scene of hepatic vein thrombosis: recognition of asymptomatic cases. Gastroenterology 1994, 106:1042–1047.

    PubMed  CAS  Google Scholar 

  54. Ahn SS, Yellin A, Sheng FC, et al.: Selective surgical therapy of the Budd-Chiari syndrome provides superior survivor rates than conservative medical management. J Vasc Surg 1987, 5:28–37.

    PubMed  Article  CAS  Google Scholar 

  55. Bilbao JI, Pueyo JC, Longo JM, et al.: Interventional therapeutic techniques in Budd-Chiari syndrome. Cardiovasc Intervent Radiol 1997, 20:112–119.

    PubMed  Article  CAS  Google Scholar 

  56. Pisani Ceretti A, Intra M, Prestipino F, et al.: Surgical and radiologic treatment of primary Budd-Chiari syndrome. World J Surg 1998, 22:48–53.

    PubMed  Article  CAS  Google Scholar 

  57. Eapen CE, Velissaris D, Heydtmann M, et al.: Favourable medium term outcome following hepatic vein recanalisation and/or transjugular intrahepatic portosystemic shunt for Budd Chiari syndrome. Gut 2006, 55:878–884.

    PubMed  Article  CAS  Google Scholar 

  58. Orloff MJ, Orloff MS, Daily PO: Long-term results of treatment of Budd-Chiari syndrome with portal decompression. Arch Surg 1992, 127:1182–1187.

    PubMed  CAS  Google Scholar 

  59. Bismuth H, Sherlock DJ: Portasystemic shunting versus liver transplantation for the Budd-Chiari syndrome. Ann Surg 1991, 214:581–589.

    PubMed  Article  CAS  Google Scholar 

  60. Gauthier F, De Dreuzy O, Valayer J, et al.: H-type shunt with an autologous venous graft for treatment of portal hypertension in children. J Pediatr Surg 1989, 24:1041–1043.

    PubMed  Article  CAS  Google Scholar 

  61. Horne MK 3rd, Figg WD, Arlen P, et al.: Increased frequency of venous thromboembolism with the combination of docetaxel and thalidomide in patients with metastatic androgen-independent prostate cancer. Pharmacotherapy 2003, 23:315–318.

    PubMed  Article  CAS  Google Scholar 

  62. Jacoby WT, Cohan RH, Baker ME, et al.: Ovarian vein thrombosis in oncology patients: CT detection and clinical significance. AJR Am J Roentgenol 1990, 155:291–294.

    PubMed  CAS  Google Scholar 

  63. Quane LK, Kidney DD, Cohen AJ: Unusual causes of ovarian vein thrombosis as revealed by CT and sonography. AJR Am J Roentgenol 1998, 171:487–490.

    PubMed  CAS  Google Scholar 

  64. Yassa NA, Ryst E: Ovarian vein thrombosis: a common incidental finding in patients who have undergone total abdominal hysterectomy and bilateral salpingo-oophorectomy with retroperitoneal lymph node dissection. AJR Am J Roentgenol 1999, 172:45–47.

    PubMed  CAS  Google Scholar 

  65. Witlin AG, Mercer BM, Sibai BM: Septic pelvic thrombophlebitis or refractory postpartum fever of undetermined etiology. J Matern Fetal Med 1996, 5:355–358.

    PubMed  Article  CAS  Google Scholar 

  66. Wysokinska EM, Hodge D, McBane RD 2nd: Ovarian vein thrombosis: incidence of recurrent venous thromboembolism and survival. Thromb Haemost 2006, 96:126–131.

    PubMed  CAS  Google Scholar 

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Correspondence to Robert D. McBane.

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McBane, R.D., Wysokinski, W.E. Treatment of venous thrombosis at unusual sites. Curr Treat Options Cardio Med 10, 136–145 (2008). https://doi.org/10.1007/s11936-008-0015-z

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Keywords

  • Inferior Vena Cava
  • Venous Thrombosis
  • Transjugular Intrahepatic Portosystemic Shunt
  • Portal Vein Thrombosis
  • Renal Vein Thrombosis