Skip to main content
Log in

Evolving treatment strategies for carotid artery stenosis

  • Published:
Current Treatment Options in Cardiovascular Medicine Aims and scope Submit manuscript

Opinion statement

Internal carotid artery stenosis is an important cause of ischemic stroke. Treatment decisions frequently center on whether the patient is symptomatic or asymptomatic. For recently symptomatic patients with severe stenosis (70% to 99%) and low to medium surgical risk, carotid endarterectomy (CEA) is extremely useful for stroke prevention. CEA is moderately useful for patients with 50% to 69% symptomatic stenosis and is not indicated for patients with symptomatic stenosis of less than 50%. CEA may be useful for select patients with severe asymptomatic stenosis (80% to 99%) but only if the surgical complication is kept below the 3% level. Carotid stenting is an emerging option for the future but is still experimental. In addition to carotid intervention, patients with carotid stenosis should receive aggressive risk factor management, including treatment with antiplatelet agents and statins.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References and Recommended Reading

  1. American Heart Association: Heart Disease and Stroke Statistics Update-2003. Dallas, TX: American Heart Association, 2002.

    Google Scholar 

  2. Wolf PA, D’Angostino RB: Epidemiology of stroke. In Stroke: Pathophysiology, Diagnosis, and Management, edn 3. Edited by Barnett HJM, et al. Philadelphia: Churchill Livingstone; 1998:3–28.

    Google Scholar 

  3. Robertson JT: Carotid endarterectomy: a saga of clinical science, personalities, and evolving technology. Stroke 1998, 29:2435–2441.

    PubMed  CAS  Google Scholar 

  4. Estol CJ: Dr. C. Miller Fisher and the history of carotid artery disease. Stroke 1996, 27:559–566.

    PubMed  CAS  Google Scholar 

  5. Wolf PA, Grotta JC: Cerebrovascular disease. Circulation 2000, 102:IV75-IV80.

    PubMed  CAS  Google Scholar 

  6. The final results of the NASCET trial. North American Symptomatic Carotid Endarterectomy Trialists’ Collaborative Group [no authors listed]. N Engl J Med 1998, 339:1415–1425.

  7. Carotid endarterectomy for patients with asymptomatic internal carotid artery stenosis. Asymptomatic Carotid Atherosclerosis Study Group [no authors listed]. JAMA 1995, 273:1421–1428.

  8. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators [no authors listed]. N Engl J Med 1991, 325:445–453.

  9. Streifler JY, Eliasziw M, Benavente OR, et al.: The risk of stroke in patients with first-ever retinal vs. hemispheric transient ischemic attacks and high-grade carotid stenosis. Arch Neurol 1995, 52:246–249.

    PubMed  CAS  Google Scholar 

  10. Eliasziw M, Streifler JY, Fox AJ, et al.: Significance of plaque ulceration in symptomatic patients with highgrade carotid stenosis. Stroke 1994, 25:304–308.

    PubMed  CAS  Google Scholar 

  11. Inzitari D, Eliasziw M, Sharpe BL, et al.: Risk factors and outcome of patients with carotid artery stenosis presenting with lacunar stroke. North American Symptomatic Carotid Endarterectomy Trial Group. Neurology 2000, 54:660–666.

    PubMed  CAS  Google Scholar 

  12. Alamowitch S, Eliasziw M, Algra A, et al.: Risk, causes, and prevention of ischaemic stroke in elderly patients with symptomatic internal-carotid artery stenosis. Lancet 2001, 357:1154–1160.

    Article  PubMed  CAS  Google Scholar 

  13. Wennberg DE, Lucas FL, Birkmeyer JD, et al.: Variation in carotid endarterectomy mortality in the Medicare population. JAMA 1998, 279:1278–1281.

    Article  PubMed  CAS  Google Scholar 

  14. Henderson RD, Eliasziw M, Fox AJ, et al.: Angiographically defined collateral circulation and risk of stroke in patients with severe carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial (NASCET). Stroke 2000, 31:128–132.

    PubMed  CAS  Google Scholar 

  15. Rothwell PM, Eliasziw M, Gutnikov SA, et al.: Analysis of pooled data from the randomized controlled trials of endarterectomy for symptomatic carotid stenosis. Lancet 2003, 361:107–116. Pools the data from the major endarterectomy trials for symptomatic stenosis and provides the treatment effect for various degrees of stenosis.

    Article  PubMed  CAS  Google Scholar 

  16. Wolf PA, Clagett GP, Easton JD, et al.: Preventing ischemic stroke in patients with prior stroke and transient ischemic attack: a statement for healthcare professionals from the Stroke Council of the American Heart Association. Stroke 1999, 30:1991–1994.

    PubMed  CAS  Google Scholar 

  17. Gorelick PB, Sacco RL, Smith DB, et al.: Prevention of a first stroke: a review of the guidelines and a multidisciplinary consensus statement from the National Stroke Association. JAMA 1999, 281:1112–1120.

    Article  PubMed  CAS  Google Scholar 

  18. Goldstein LB, Adams R, Becker K, et al.: Primary prevention of ischemic stroke: a statement for healthcare professionals from the Stroke Council of the American Heart Association. Circulation 2001, 103:163–182. Excellent overview of various primary prevention strategies.

    PubMed  CAS  Google Scholar 

  19. Hart RG, Bailey RD: An assessment of guidelines for prevention of ischemic stroke. Neurology 2002, 59:977–982.

    Article  PubMed  Google Scholar 

  20. Taylor DW, Barnett HJM, Haynes RB, et al.: Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: a randomized controlled trial. ASA and Carotid Endarterectomy (ACE) Trial Collaborators. Lancet 1999, 353:2179–2184.

    Article  PubMed  CAS  Google Scholar 

  21. Roubin GS, Gishel N, Iyer SS, et al.: Immediate and late clinical outcomes of carotid artery stenting in patients with symptomatic and asymptomatic carotid artery stenosis: a 5-year prospective analysis. Circulation 2001, 103:532–537.

    PubMed  CAS  Google Scholar 

  22. Kastrup A, Groschel K, Krapf H, et al.: Early outcome of carotid angioplasty and stenting with and without cerebral protection devices: a systematic review of the literature. Stroke 2003, 34:813–819.

    Article  PubMed  Google Scholar 

  23. Albers GW, Hart RG, Lutsep HL, et al.: Supplement to the guidelines for the management of transient ischemic attacks. Stroke 1999, 30:2502–2511.

    PubMed  CAS  Google Scholar 

  24. Inzitari D, Eliasziw M, Gates P, et al.: The causes and risk of stroke in patients with asymptomatic internal-carotidartery stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med 2000, 342:1693–1700.

    Article  PubMed  CAS  Google Scholar 

  25. Ross R: Atherosclerosis—an inflammatory disease. N Engl J Med 1999, 340:115–126.

    Article  PubMed  CAS  Google Scholar 

  26. Neal B, MacMahon S: PROGRESS (perindopril protection against recurrent stroke study): rationale and design. PROGRESS Management Committee. J Hypertens 1995, 13:1869–1873.

    Article  PubMed  CAS  Google Scholar 

  27. MacMahon S, Rodgers A, Collins R: Blood pressure, antihypertensive treatment and stroke risk. J Hypertens 1994, 12(suppl):S5-S45.

    CAS  Google Scholar 

  28. Effects of an angiotensin-converting enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators [no authors listed]. N Engl J Med 2000, 342:145–153.

  29. Perry HM, Davis BR, Price TR, et al.: Effect of treating isolated systolic hypertension on the risk of developing various types and subtypes of stroke. JAMA 2000, 284:465–471.

    Article  PubMed  Google Scholar 

  30. Randomised trial of a perindopril-based bloodpressure lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack. PROGRESS Collaborative Group [no authors listed]. Lancet 2001, 358:1033–1041.

  31. Psaty BM, Furberg CD, Kuller LH, et al.: Association between blood pressure level and the risk of myocardial infarction, stroke, and total mortality. Arch Intern Med 2001, 161:1183–1192.

    Article  PubMed  CAS  Google Scholar 

  32. Dahlof B, Devereaux RB, Kjeldsen SE, et al.: Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomized trial against atenolol. Lancet 2002, 359:995–1003.

    Article  PubMed  CAS  Google Scholar 

  33. ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group: Major outcomes in highrisk hypertensive patients randomized to angiotensinconverting enzyme inhibitors or calcium channel blocker vs. diuretic. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002, 288:2981–2997.

    Article  Google Scholar 

  34. Psaty BM, Smith NL, Siscovick DS, et al.: Health outcomes associated with antihypertensive therapies used as first-line agents: a systematic review and metaanalysis. JAMA 1997, 277:739–745.

    Article  PubMed  CAS  Google Scholar 

  35. Pahor M, Psaty BM, Alderman MH, et al.: Health outcomes associated with calcium antagonists compared with other first-line antihypertensive agents: a meta-analysis of randomized controlled trials. Lancet 2000, 356:1949–1954.

    Article  PubMed  CAS  Google Scholar 

  36. Rosenson RS, Tangney CC: Antiatherothrombotic properties of statins. JAMA 1998, 279:1643–1650.

    Article  PubMed  CAS  Google Scholar 

  37. Fine-Edelstein JS, Wolf PA, O’Leary DH, et al.: Precursors of extracranial carotid atherosclerosis in the Framingham Study. Neurology 1994, 44:1046–1050.

    PubMed  CAS  Google Scholar 

  38. O’Leary DH, Polak JF, Kronmal RA, et al.: Thickening of the carotid wall. A marker for atherosclerosis in the elderly? Cardiovascular Health Study Collaborative Research Group. Stroke 1996, 27:224–231.

    PubMed  CAS  Google Scholar 

  39. Gorelick PB: Stroke prevention therapy beyond antithrombotics: unifying mechanisms in ischemic stroke pathogenesis and implications for therapy. Stroke 2002, 33:862–875.

    Article  PubMed  Google Scholar 

  40. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandanavian Simvastatin Survival Study (4S) [no authors listed]. Lancet 1994, 344:1383–1389.

  41. White HD, Simes RJ, Anderson NE, et al.: Pravastatin therapy and the risk of stroke. N Engl J Med 2000, 343:317–326.

    Article  PubMed  CAS  Google Scholar 

  42. Blauw GJ, Lagaay AM, Smelt AHM, Westendorp GJ: Stroke, statins, and cholesterol: a meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors. Stroke 1997, 28:946–950.

    PubMed  CAS  Google Scholar 

  43. Straus SE, Majumdar SR, McAlister FA: New evidence for stroke prevention: scientific review. JAMA 2002, 288:1388–1395. Presents the evidence for both medical and surgical methods of stroke prevention, along with tables that give estimates on the size of the treatment effects for the various modalities.

    Article  PubMed  Google Scholar 

  44. Chaturvedi S: Should the multicenter carotid endarterectomy trials be repeated? Arch Neurol 2003, 60:774–775.

    Article  PubMed  Google Scholar 

  45. Welch GN, Loscalzo J: Homocysteine and atherothrombosis. N Engl J Med 1998, 338:1042–1050.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Van Stavern, R.B., Chaturvedi, S. Evolving treatment strategies for carotid artery stenosis. Curr Treat Options Cardio Med 6, 105–112 (2004). https://doi.org/10.1007/s11936-004-0038-z

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11936-004-0038-z

Keywords

Navigation