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Opinion Statement

In the setting of acute myocardial infarction, the timely recognition and treatment of cardiogenic shock are essential in reducing the incidence of death. Patients with cardiogenic shock should be treated aggressively with a combination of pharmacologic agents and mechanical support devices to achieve stabilization. Once stabilization has been achieved, the ultimate goal should be the restoration of flow in the infarct-related artery. This is best achieved with angioplasty or bypass surgery. In those centers not equipped for these procedures, thrombolysis should be performed, and the patient should then be transferred to a higher-level facility.

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References and Recommended Reading

  1. Griffith GC, Wallace WB, Cochran B, et al.: The treatment of shock associated with myocardial infarction. Circulation 1954, 9:527–532.

    PubMed  CAS  Google Scholar 

  2. Hands ME, Rutherford JD, Muller JE, et al.: The in hospital development of cardiogenic shock after myocardial infarction: incidence, predictors of occurrence, outcomes and prognostic factors. J Am Coll Cardiol 1989, 14(1):40–46.

    Article  PubMed  CAS  Google Scholar 

  3. Holmes DR, Bates ER, Kleiman NS, et al.: Contemporary reperfusion therapy for cardiogenic shock: the GUSTO-I trial experience. Global utilization of streptokinase and tissue plasminogen activator for occluded coronary arteries. J Am Coll Cardiol 1995, 26(3):668–674. This study provides an excellent overview of the incidence and clinical implications of cardiogenic shock in the thrombolytic era.

    Article  PubMed  Google Scholar 

  4. Leor J, Goldbourt U, Reicher-Reiss H, et al.: Cardiogenic shock complicating acute myocardial infarction in patients without heart failure on admission: incidence, risk factors, and outcome. SPRINT study group. Am J Med 1993, 94(3):256–273.

    Article  Google Scholar 

  5. Alpert JS, Becker RC: Cardiogenic shock: elements of etiology, diagnosis, and therapy. Clin Cardiol 1993, 16(3):182–190.

    PubMed  CAS  Google Scholar 

  6. Page DL, Caulfield JB, Kastor JA, et al.: Myocardial changes associated with cardiogenic shock. N Engl J Med 1971, 285(3):133–137.

    Article  PubMed  CAS  Google Scholar 

  7. Moscucci M, Bates ER: Cardiogenic shock. Cardiol Clin 1995, 3(3):391–406. An excellent review article that details the incidence, etiology, pathophysiology, recognition, and treatment of cardiogenic shock.

    Google Scholar 

  8. Califf RM, Bengtson JR: Cardiogenic shock. N Engl J Med 1994, 330(24):1724–1730. This article highlights the recognition and treatment of cardiogenic shock.

    Article  PubMed  CAS  Google Scholar 

  9. Mueller HS: Role of intra-aortic counterpulsation in cardiogenic shock and acute myocardial infarction. Cardiology 1994, 84(3):168–174.

    PubMed  CAS  Google Scholar 

  10. Goldberg RJ, Gore JM, Alpert JS, et al.: Cardiogenic shock after acute myocardial infarction. Incidence and mortality from a community-wide perspective, 1975–1988. N Engl J Med 1991, 325(16):1117–1122.

    Article  PubMed  CAS  Google Scholar 

  11. Bengtson JR, Kaplan AJ, Pieper KS, et al.: Prognosis in cardiogenic shock after acute myocardial infarction in the interventional era. J Am Coll Cardiol 1992, 20(7):1482–1489.

    Article  PubMed  CAS  Google Scholar 

  12. Bates ER, Topol EJ: Limitations of thrombolytic therapy for acute myocardial infarction complicated by congestive heart failure and cardiogenic shock. J Am Coll Cardiol 1991, 18(4):1077–1084.

    Article  PubMed  CAS  Google Scholar 

  13. Gruppo Italiano per lo Studio della Streptochinasi nell’Infarto Miocardico (GISSI): Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 1986, 1(8478):397–402.

    Google Scholar 

  14. Barry WL, Sarembock IJ: Cardiogenic shock: therapy and prevention. Clin Cardiol 1998, 21(2):72–80.

    Article  PubMed  CAS  Google Scholar 

  15. Bates ER, Stomel RJ, Hockman JS, et al.: The use of intraaortic balloon counterpulsation as an adjunct to reperfusion therapy in cardiogenic shock. Int J Cardiol 1998, 65(suppl 1):S37-S42.

    Article  PubMed  Google Scholar 

  16. Kovack PJ, Rasak MA, Bates ER, et al.: Thrombolysis plus aortic counterpulsation: improved survival in patients who present to community hospitals with cardiogenic shock. J Am Coll Cardiol 1997, 29(7):1454–1458.

    Article  PubMed  CAS  Google Scholar 

  17. Lee L, Erbel R, Brown TM, et al.: Multicenter registry of angioplasty therapy for cardiogenic shock: initial and long-term survival. J Am Coll Cardiol 1991, 17(3):599–603.

    Article  PubMed  CAS  Google Scholar 

  18. Smalling RW: Transvalvular left ventricular assistance in acute myocardial infarction with cardiogenic shock and high risk angioplasty: experimental and clinical results with the Hemopump. J Interven Cardiol 1995, 8(3):265–273.

    CAS  Google Scholar 

  19. Alpert JS, Becker RC: Mechanisms and management of cardiogenic shock. Crit Care Clin 1993, 9(2):205–218.

    PubMed  CAS  Google Scholar 

  20. Klocke RK, Mager G, Kux A, et al.: Effects of a twenty four hour milrinone infusion in patients with severe heart failure and cardiogenic shock as a function of the hemodynamic initial condition. Am Heart J 1991, 121(suppl):1965–1973.

    Article  PubMed  CAS  Google Scholar 

  21. Dunkman WB, Leinbach RC, Buckley MI, et al.: Clinical and hemodynamic results of intraaortic balloon pumping and surgery for cardiogenic shock. Circulation 1972, 46(3):465–477.

    PubMed  CAS  Google Scholar 

  22. Kern MJ, Aguirre FV, Tatineni S, et al.: Enhanced coronary blood flow velocity during intraaortic balloon counterpulsation in critically ill patients. J Am Coll Cardiol 1993, 21(2):359–368.

    Article  PubMed  CAS  Google Scholar 

  23. DeWood MA, Notske RN, Hensley GR, et al.: Intraaortic balloon counterpulsation with and without reperfusion for myocardial infarction shock. Circulation 1975, 61(6):1105–1112.

    Google Scholar 

  24. Eltchaninoff H, Alexios DP, Whitlow PL: Complications associated with percutaneous placement and use of intraaortic balloon counterpulsation. Am J Cardiol 1993, 71:328–332.

    Article  PubMed  CAS  Google Scholar 

  25. Merhige ME, Smalling RW, Cassidy D, et al.: Effect of the hemopump left ventricular assist device on regional myocardial perfusion. Reduction of ischemia during coronary occlusion. Circulation 1989, 80(5 Pt2):158–166.

    Google Scholar 

  26. Smalling RW, Cassidy DB, Barrett R, et al.: Improved regional myocardial blood flow, left ventricular unloading and infarct salvage using an axial flow, transvalvular left ventricular assist device: a comparison with intraaortic balloon counter pulsation and reperfusion alone in a canine infarction model. Circulation 1992, 85(3):1152–1159.

    PubMed  CAS  Google Scholar 

  27. Smalling RW, Sweeney M, Lachterman B, et al.: Transvalvular left ventricular assistance in cardiogenic shock secondary to acute myocardial infarction. Evidence for recovery from near fatal myocardial stunning. J Am Coll Cardiol 1994, 23(3):637–644.

    Article  PubMed  CAS  Google Scholar 

  28. Shawl FA, Domanski MJ, Hernandez TJ, et al.: Emergency percutaneous cardiopulmonary bypass support in cardiogenic shock from acute myocardial infarction. Am J Cardiol 1989, 64(16):967–970.

    Article  PubMed  CAS  Google Scholar 

  29. Stack RS, Califf RM, Hinohara T, et al.: Survival and cardiac event rates in the first year after emergency coronary angioplasty for acute myocardial infarction. J Am Coll Cardiol 1988, 11(6):1141–1149.

    Article  PubMed  CAS  Google Scholar 

  30. Antonucci D, Valenti R, Santoro GM, et al.: Systematic direct angioplasty and stent-supported direct angioplasty therapy for cardiogenic shock complicating acute myocardial infarction: in-hospital and longterm survival. J Am Coll Cardiol 1998, 31(2):294–300.

    Article  Google Scholar 

  31. O’Neill WW: Interventional approach to the patient in cardiogenic shock. In Interventional Cardiovascular Medicine. Edited by Roubin GS, Califf RM, O’Neill WW, et al. New York: Churchill Livingstone; 1994:265.

    Google Scholar 

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Rihner, M., Smalling, R. Cardiogenic shock. Curr Treat Options Cardio Med 2, 55–64 (2000). https://doi.org/10.1007/s11936-000-0028-8

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  • DOI: https://doi.org/10.1007/s11936-000-0028-8

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