Abstract
Purpose of Review
To present the latest evidence on thulium fiber laser (TFL) effects on tissue, during lithotripsy and ablation, emphasizing on generated temperatures, thermal damage thresholds, incision depths, areas of coagulation, and laser damage.
Recent Findings
Lasers are frequently utilized during endoscopic treatment of different urological conditions. The holmium:yttrium–aluminum-garnet (Ho:YAG) is most frequently used for various types of stones and soft tissue. The TFL has been recently introduced, offering several advantages. However, its activity on tissue during upper and lower tract endourology is poorly understood.
Summary
At equivalent power settings, TFL and Ho:YAG generate similar temperature changes during lithotripsy. TFL has a shallow incision depth during tissue ablation. Compared to SP TFL, (cw) TFL results in a broader coagulation zone, whereas SP TFL gives of Ho:YAG-similar incision, and (cw) TFL offers a quick, precise cut with more carbonization.
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References
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
Herrmann TR, Liatsikos EN, Nagele U, Traxer O, Merseburger AS. EAU guidelines on laser technologies. Eur Urol. 2012;61(4):783–95. https://doi.org/10.1016/j.eururo.2012.01.010.
Larizgoitia I, Pons JM. A systematic review of the clinical efficacy and effectiveness of the holmium:YAG laser in urology. BJU Int. 1999;84(1):1–9. https://doi.org/10.1046/j.1464-410x.1999.00096.x.
Johnson DE, Cromeens DM, Price RE. Use of the holmium:YAG laser in urology. Lasers Surg Med. 1992;12(4):353–63. https://doi.org/10.1002/lsm.1900120402.
Aldoukhi AH, Black KM, Ghani KR. Emerging laser techniques for the management of stones. Urol Clin North Am. 2019;46(2):193–205. https://doi.org/10.1016/j.ucl.2018.12.005.
Kyriazis I, Świniarski PP, Jutzi S, Wolters M, Netsch C, Burchardt M, et al. Transurethral anatomical enucleation of the prostate with Tm:YAG support (ThuLEP): review of the literature on a novel surgical approach in the management of benign prostatic enlargement. World J Urol. 2015;33(4):525–30. https://doi.org/10.1007/s00345-015-1529-0.
Li K, Xu Y, Tan M, Xia S, Xu Z, Xu D. A retrospective comparison of thulium laser en bloc resection of bladder tumor and plasmakinetic transurethral resection of bladder tumor in primary non-muscle invasive bladder cancer. Lasers Med Sci. 2019;34(1):85–92. https://doi.org/10.1007/s10103-018-2604-8.
Rieken M, Bachmann A. Laser treatment of benign prostate enlargement–which laser for which prostate? Nat Rev Urol. 2014;11(3):142–52. https://doi.org/10.1038/nrurol.2014.23.
•• Sierra A, Corrales M, Piñero A, Traxer O. Thulium fiber laser pre-settings during ureterorenoscopy: Twitter’s experts’ recommendations. World J Urol. 2022;40(6):1529–35. https://doi.org/10.1007/s00345-022-03966-9. Important study demonstrating significant differences in applied laser settings between urologists.
• Becker B, Enikeev D, Glybochko P, Rapoport L, Taratkin M, Gross AJ, et al. Effect of optical fiber diameter and laser emission mode (cw vs pulse) on tissue damage profile using 1.94 µm Tm:fiber lasers in a porcine kidney model. World J Urol. 2020;38(6):1563–8. https://doi.org/10.1007/s00345-019-02944-y. First study comparing TFL with Ho:YAG during laser tissue ablation.
Kronenberg P, Traxer O. The laser of the future: reality and expectations about the new thulium fiber laser-a systematic review. Transl Androl Urol. 2019;8(Suppl 4):S398-s417. https://doi.org/10.21037/tau.2019.08.01.
Fried NM, Murray KE. High-power thulium fiber laser ablation of urinary tissues at 1.94 microm. J Endourol. 2005;19(1):25–31. https://doi.org/10.1089/end.2005.19.25.
Fried NM. Recent advances in infrared laser lithotripsy [Invited]. Biomed Opt Express. 2018;9(9):4552–68. https://doi.org/10.1364/boe.9.004552.
Ventimiglia E, Doizi S, Kovalenko A, Andreeva V, Traxer O. Effect of temporal pulse shape on urinary stone phantom retropulsion rate and ablation efficiency using holmium:YAG and super-pulse thulium fibre lasers. BJU Int. 2020;126(1):159–67. https://doi.org/10.1111/bju.15079.
Fried NM, Irby PB. Advances in laser technology and fibre-optic delivery systems in lithotripsy. Nat Rev Urol. 2018;15(9):563–73. https://doi.org/10.1038/s41585-018-0035-8.
Chan KF, Pfefer TJ, Teichman JM, Welch AJ. A perspective on laser lithotripsy: the fragmentation processes. J Endourol. 2001;15(3):257–73. https://doi.org/10.1089/089277901750161737.
Sea J, Jonat LM, Chew BH, Qiu J, Wang B, Hoopman J, et al. Optimal power settings for Holmium:YAG lithotripsy. J Urol. 2012;187(3):914–9. https://doi.org/10.1016/j.juro.2011.10.147.
Zhong P, Tong HL, Cocks FH, Pearle MS, Preminger GM. Transient cavitation and acoustic emission produced by different laser lithotripters. J Endourol. 1998;12(4):371–8. https://doi.org/10.1089/end.1998.12.371.
Giambattista ARB, Richardson RC. College physics. Boston: McGraw-Hill; 2004.
Teichman JM, Vassar GJ, Glickman RD. Holmium:yttrium-aluminum-garnet lithotripsy efficiency varies with stone composition. Urology. 1998;52(3):392–7. https://doi.org/10.1016/s0090-4295(98)00239-8.
Urano M, Kuroda M, Nishimura Y. For the clinical application of thermochemotherapy given at mild temperatures. Int J Hyperth. North American Hyperthermia Group. 1999;15(2):79–107. https://doi.org/10.1080/026567399285765.
He X, McGee S, Coad JE, Schmidlin F, Iaizzo PA, Swanlund DJ, et al. Investigation of the thermal and tissue injury behaviour in microwave thermal therapy using a porcine kidney model. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 2004;20(6):567–93. https://doi.org/10.1080/0265673042000209770.
Liang P, Dong B, Yu X, Yu D, Cheng Z, Su L, et al. Computer-aided dynamic simulation of microwave-induced thermal distribution in coagulation of liver cancer. IEEE Trans Biomed Eng. 2001;48(7):821–9. https://doi.org/10.1109/10.930907.
Bach T, Muschter R, Sroka R, Gravas S, Skolarikos A, Herrmann TR, et al. Laser treatment of benign prostatic obstruction: basics and physical differences. Eur Urol. 2012;61(2):317–25. https://doi.org/10.1016/j.eururo.2011.10.009.
Peng Y, Liu M, Ming S, Yu W, Li L, Lu C, et al. Safety of a novel thulium fiber laser for lithotripsy: an in vitro study on the thermal effect and its impact factor. J Endourol. 2020;34(1):88–92. https://doi.org/10.1089/end.2019.0426.
• Hardy LA, Wilson CR, Irby PB, Fried NM. Thulium fiber laser lithotripsy in an in vitro ureter model. J Biomed Opt. 2014;19(12): 128001. https://doi.org/10.1117/1.jbo.19.12.128001. First study comparing TFL with Ho:YAG during laser lithotripsy.
Taratkin M, Laukhtina E, Singla N, Kozlov V, Abdusalamov A, Ali S, et al. Temperature changes during laser lithotripsy with Ho:YAG laser and novel Tm-fiber laser: a comparative in-vitro study. World J Urol. 2020;38(12):3261–6. https://doi.org/10.1007/s00345-020-03122-1.
Andreeva V, Vinarov A, Yaroslavsky I, Kovalenko A, Vybornov A, Rapoport L, et al. Preclinical comparison of superpulse thulium fiber laser and a holmium:YAG laser for lithotripsy. World J Urol. 2020;38(2):497–503. https://doi.org/10.1007/s00345-019-02785-9.
Molina WR, Carrera RV, Chew BH, Knudsen BE. Temperature rise during ureteral laser lithotripsy: comparison of super pulse thulium fiber laser (SPTF) vs high power 120 W holmium-YAG laser (Ho:YAG). World J Urol. 2021;39(10):3951–6. https://doi.org/10.1007/s00345-021-03619-3.
Kallidonis P, Kamal W, Panagopoulos V, Vasilas M, Amanatides L, Kyriazis I, et al. Thulium laser in the upper urinary tract: Does the heat generation in the irrigation fluid pose a risk? Evidence from an in vivo experimental study. J Endourol. 2016;30(5):555–9. https://doi.org/10.1089/end.2015.0768.
Noureldin YA, Farsari E, Ntasiotis P, Adamou C, Vagionis A, Vrettos T, et al. Effects of irrigation parameters and access sheath size on the intra-renal temperature during flexible ureteroscopy with a high-power laser. World J Urol. 2021;39(4):1257–62. https://doi.org/10.1007/s00345-020-03287-9.
Dau JJ, Hall TL, Maxwell AD, Ghani KR, Roberts WW. Effect of chilled irrigation on caliceal fluid temperature and time to thermal injury threshold during laser lithotripsy. in vitro model J Endourol. 2021;35(5):700–5. https://doi.org/10.1089/end.2020.0896.
Aldoukhi AH, Dau JJ, Majdalany SE, Hall TL, Ghani KR, Hollingsworth JM, et al. Patterns of laser activation during ureteroscopic lithotripsy: effects on caliceal fluid temperature and thermal dose. J Endourol. 2021;35(8):1217–22. https://doi.org/10.1089/end.2020.1067.
Verdaasdonk RM, van Swol CF, Grimbergen MC, Rem AI. Imaging techniques for research and education of thermal and mechanical interactions of lasers with biological and model tissues. J Biomed Opt. 2006;11(4): 041110. https://doi.org/10.1117/1.2338817.
Doizi S, Germain T, Panthier F, Comperat E, Traxer O, Berthe L. Comparison of Holmium:YAG and Thulium Fiber lasers on soft tissue : an ex vivo study. J Endourol. 2021. https://doi.org/10.1089/end.2021.0263.
Khoder WY, Zilinberg K, Waidelich R, Stief CG, Becker AJ, Pangratz T, et al. Ex vivo comparison of the tissue effects of six laser wavelengths for potential use in laser supported partial nephrectomy. J Biomed Opt. 2012;17(6): 068005. https://doi.org/10.1117/1.jbo.17.6.068005.
Taratkin M, Kovalenko A, Laukhtina E, Paramonova N, Spivak L, Wachtendorf LJ, et al. Ex vivo study of Ho:YAG and thulium fiber lasers for soft tissue surgery: which laser for which case? Lasers Med Sci. 2020. https://doi.org/10.1007/s10103-020-03189-7.
Taratkin M, Netsch C, Enikeev D, Gross AJ, Herrmann TRW, Korolev D, et al. The impact of the laser fiber-tissue distance on histological parameters in a porcine kidney model. World J Urol. 2021;39(5):1607–12. https://doi.org/10.1007/s00345-020-03326-5.
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V Gkolezakis: Data management, data analysis, manuscript writing. P Rice: Data management, interpreting data. B K Somani: Interpreting data, critical manuscript revision. T Tokas: Protocol/project development, manuscript writing.
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Gkolezakis, V., Rice, P., Somani, B.K. et al. Thulium Fiber Laser Behavior on Tissue During Upper- and Lower-Tract Endourology. Curr Urol Rep 23, 271–278 (2022). https://doi.org/10.1007/s11934-022-01117-6
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DOI: https://doi.org/10.1007/s11934-022-01117-6