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MR-Guided High-Intensity Directional Ultrasound Ablation of Prostate Cancer


Purpose of Review

The goal of this paper was to review the novel treatment modality of high-intensity transurethral directional ultrasound for prostate cancer.

Recent Findings

Prostate cancer is a heterogeneous disease with some patients electing for active surveillance and focal therapies instead of definitive treatment with radical prostatectomy or radiation therapy. Prostate MRI has become a cornerstone of prostate cancer diagnosis, targeted biopsy, and treatment planning. Transurethral high-intensity directional ultrasound allows for MRI-guided ablation of the prostate gland with the ability to contour boundaries and spare critical structures, such as the neurovascular bundle and urinary sphincter. Although results are still emerging, this may offer patients a new option for focal therapy with a favorable side-effect profile.


High-intensity transurethral directional ultrasound is an emerging treatment modality for both whole-gland and focal ablation with promising early results. Further research is needed to establish safety, tolerability, and long-term oncologic outcomes.

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Corresponding author

Correspondence to Samuel J. Galgano.

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Conflict of Interest

SJG and SRB have no relevant disclosures. VP has received an honorarium from Profound Medical for a research study. SA has received travel reimbursement from Profound Medical and research support from Profound Medical and the Radiological Society of North America.

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This article is part of the Topical Collection on New Imaging Techniques

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Galgano, S.J., Planz, V.B., Arora, S. et al. MR-Guided High-Intensity Directional Ultrasound Ablation of Prostate Cancer. Curr Urol Rep 22, 3 (2021).

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  • Prostate cancer
  • Focal therapy
  • High-intensity ultrasound
  • Ablation