Purpose of Review
To review novel, non-surgical therapies for erectile dysfunction (ED).
Recently, a landmark study identified the SIM1 locus, involved in the leptin-melanocortin pathway, as an independent risk factor for ED and a potential target for novel therapies. The recent literature otherwise has focused on low-intensity shock wave therapy (LiSWT), with several randomized trials and meta-analyses suggesting therapeutic efficacy.
There are few novel oral agents for ED. There is growing evidence suggesting efficacy of intracavernosal stem cells therapy and low-intensity shock wave therapy (LiSWT), although these therapies are still investigational. A better understanding of the pathophysiologic spectrum of ED will offer new opportunities for novel, non-surgical therapies for ED.
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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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Conflict of Interest
Darshan P. Patel declares no potential conflicts of interest.
Alexander W. Pastuszak reports advisor, speaker, consultant, and research and fellowship support from Endo Pharmaceuticals; is an advisor for Boston Scientific and Antares Pharmaceuticals; and holds a leadership position with Woven Health.
James M. Hotaling reports a research and fellowship grant from Endo Pharmaceuticals and a fellowship grant from Boston Scientific; and holds leadership positions with Nanonc, SteamDx, and Andro360.
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Patel, D.P., Pastuszak, A.W. & Hotaling, J.M. Emerging Treatments for Erectile Dysfunction: a Review of Novel, Non-surgical Options. Curr Urol Rep 20, 44 (2019). https://doi.org/10.1007/s11934-019-0908-2
- Erectile dysfunction
- Sexual dysfunction
- Dietary supplement
- Platelet-rich plasma
- Genetic therapy
- Extracorporeal shockwave therapy