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Environmental Toxins and Male Fertility

  • Andrology and Infertility (L Lipshultz, Section Editor)
  • Published:
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Abstract

Purpose of Review

Global industrialization has increased population exposure to environmental toxins. A global decline in sperm quality over the last few decades raises questions about the adverse impact of environmental toxins on male reproductive health.

Recent Findings

Multiple animal- and human-based studies on exposure to environmental toxins suggest a negative impact on semen quality, in terms of sperm concentration, motility, and/or morphology. These toxins may exert estrogenic and/or anti-androgenic effects, which in turn alter the hypothalamic-pituitary-gonadal axis (HPGA), induce sperm DNA damage, or cause sperm epigenetic changes.

Summary

This chapter will discuss the most recent literature about the most common environmental toxins and their impact on spermatogenesis and its consequences on male fertility. Understanding the presence and underlying mechanism of these toxins will help us preserve the integrity of the male reproduction system and formulate better regulations against their indiscriminate use.

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  1. University of Illinois at Chicago, 820 S. Wood St., Suite 515 CSN, Chicago, IL, 60612, USA

    Mahmoud Mima, David Greenwald & Samuel Ohlander

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  1. Mahmoud Mima
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Mima, M., Greenwald, D. & Ohlander, S. Environmental Toxins and Male Fertility. Curr Urol Rep 19, 50 (2018). https://doi.org/10.1007/s11934-018-0804-1

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