Convective Radiofrequency Water Vapor Thermal Therapy with Rezūm System
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Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) are amongst the most commonly treated conditions by urologists. Minimally invasive therapies for the treatment of BPH/LUTS have garnered increased interest as new technology has emerged, improving durability, efficacy, and safety. This paper reviews the most recent literature regarding water vapor therapy, a convective thermal therapy that ablates prostatic tissue.
The current literature includes a pilot study of 65 men and a randomized controlled trial (RCT) of 197 men investigating the efficacy and safety profile of water vapor therapy up to 2 years. Subjects treated with water vapor therapy demonstrated a 51% reduction in IPSS from baseline, sustained at 24 months (p < 0.0001). Durable improvements in max flow rate (Qmax) and quality of life (QoL) were also achieved, while no changes in sexual function were observed. Reporting of adverse events (AEs) reveals predominantly Clavien grade I complications that were self-limited.
The clinical efficacy and safety of water vapor therapy are durable to 24 months making it an attractive alternative for patients seeking a minimally invasive treatment for LUTS due to BPH.
KeywordsProstate Prostatic hyperplasia Lower urinary tract symptoms Thermal conductivity Minimally invasive therapies
Compliance with Ethical Standards
Conflict of Interest
Sevann Helo and Bradley Holland each declare no potential conflicts of interest.
Kevin T. McVary reports and Lilly/ICOS Self 1/1/11 Present Consultant or Advisor, Scientific Study or Trial, Honorarium, Principal Investigator Y Tadalafil ED and BPHÐIDDK Self 1/1/11 Present Principal Investigator and consultant Y N/A OAB and EDÛoston Scientific (formerly AMS) Self 7/1/13 Present Principal Investigator—Fellowship Grant Y N/A ED and is a section editor for Current Urology Reports.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance
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