Current Urology Reports

, Volume 14, Issue 4, pp 309–314 | Cite as

Varicocele and Hypogonadism

  • Ali Dabaja
  • Matthew Wosnitzer
  • Marc GoldsteinEmail author
Men's Health (J Mulhall, Section Editor)


Accumulating evidence suggests that varicocele, long associated with male infertility, is also a risk factor for low testosterone levels. The exact pathophysiology of the negative effects of varicocele on testicular function is not well understood, but theories include venous stasis, increased testicular temperature, oxidative stress, and resulting toxic environment. While prior studies report conflicting effects of non-microsurgical varicocelectomy on testosterone level, recent literature demonstrates that microsurgical varicocelectomy improves testosterone levels in men with varicocele and low testosterone preoperatively.


Varicocele Hypogonadism Low testosterone Microsurgical varicocelectomy Subinguinal varicocele repair Leydig cell function 


Compliance with Ethics Guidelines

Conflict of Interest

Dr. Ali Dabaja reported no potential conflicts of interest relevant to this article. Dr. Matthew Wosnitzer reported no potential conflicts of interest relevant to this article. Dr. Marc Goldstein reported no potential conflicts of interest relevant to this article.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Ali Dabaja
    • 1
  • Matthew Wosnitzer
    • 1
  • Marc Goldstein
    • 1
    • 2
    Email author
  1. 1.Department of Urology and Institute for Reproductive Medicine, Weill Cornell Medical CollegeNew YorkUSA
  2. 2.The Center for Male Reproductive Medicine and Microsurgery at Weill Cornell Medical College/New York - Presbyterian HospitalNew YorkUSA

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