Abstract
Minimally invasive therapies (MIT) have become a viable option for the treatment of benign prostatic hyperplasia. Transurethral microwave thermotherapy (TUMT), the MIT used most commonly, uses microwaves to generate heat to cause coagulation necrosis in the prostate. One TUMT device integrates the monitoring of intraprostatic temperatures to customize the thermal treatment to each patient. The need to customize TUMT treatments comes from differences in prostatic blood flow, which acts as a heat sink and dissipates thermal energy. This causes the amount of energy necessary to cause a significant increase in temperature to vary. ProstaLund (ProstaLund Operations AB, Sweden) feedback treatment (PLFT) allows the physician to monitor the temperatures created in the prostate during treatment and adjust the energy level to reach and maintain therapeutic temperatures in the prostate adenoma. Clinical studies have demonstrated the effective treatment of prostatic diseases using the PLFT machine. This article reviews the development and capabilities of the PLFT device.
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Wagrell L, Schelin S, Bolmsjö M, Mattiasson A: Aspects on transurethral microwave thermotherapy of benign prostatic hyperplasia. Tech Urol 2000, 6:251–255. Noteworthy report.
Brehmer M, Baba S: Transurethral microwave thermotherapy: How does it work? J Endurol 2000, 14:611–615.
Eliasson TU, Abramsson LB, Pettersson GT, Damber JE: Responders and non-responders to treatment of benign prostatic hyperplasia with transurethral microwave thermotherapy. Scand J Urol Nephrol 1995, 29:183–191.
de Wildt MJ, Tubaro A, Hofner K, et al.: Responders and nonresponders to transurethral microwave thermotherapy: a multicenter retrospective analysis. J Urol 1995, 154:1775–1778.
de Wildt MJ, de la Rosette J: Transurethral microwave thermotherapy: an evolving technology in the treatment of benign prostatic enlargement. Br J Urol 1995, 76:531–538.
Dahlstrand C, Walden M, Geirsson G, Pettersson S: Transurethral microwave thermotherapy versus transurethral resection for symptomatic benign prostatic obstruction: a prospective randomized study with a 2-year follow-up. Br J Urol 1995, 76:614–618.
Baba S, Nakamura K, Tachibana M, Murai M: Transurethral microwave thermotherapy for the management of benign prostatic hyperplasia: durability of response. Urology 1996, 47:664–671.
Brehmer M, Kinn AC: Transurethral microwave thermotherapy for benign prostatic hyperplasia: subjective response and urodynamic changes. Scand J Urol Nephrol 1996, 30:307–311.
Glass JM, Bdesha AS, Witherow RO: Microwave thermotherapy: a long-term follow-up of 67 patients from a single center. Br J Urol 1998, 81:377–382.
de la Rosette J, Froeling FM, Debruyne FM: Clinical results with microwave thermotherapy of benign prostatic hyperplasia. Eur Urol 1993, 23(suppl 1):68–71.
Abbou CC, Payan C, Viens-Bitker C, et al.: Transrectal and transurethral hyperthermia versus sham treatment in benign prostatic hyperplasia: a double-blind randomized multicentre clinical trial. Br J Urol 1995, 76:619–624.
Hoffmann A, de la Rosette J, Wijkstra H: Intraprostatic temperature monitoring during transurethral microwave thermotherapy: status and future development. J Endourol 2000, 14:637–642.
Laguna MP, Muschter R, Debruyne F: Microwave thermotherapy: historical overview. J Endourol 2000, 14:603–609.
Bhowmick P, Coad JE, Bhowmick S, et al.: In vitro assessment of the efficacy of thermal therapy in human benign prostatic hyperplasia. Int J Hyperthermia 2003, in press. Noteworthy report.
Jung H: A generalized concept for cell killing by heat: effect of chronically induced thermotolerance. Radiat Res 1991, 127:235–242.
Lindegaard JC, Bentzen SM: A mathematical model for cell killing by heat applied to a C3H mammary carcinoma in vivo. Int J Radiat Biol 1993, 64:113–117.
Beacco CM, Mordon SR, Brunetaud JM: Development and experimental in vivo validation of mathematical modeling of laser coagulation. Laser Surg Med 1994, 14:362–373.
Dewey WC: Arrhenius relationships from the molecule and cell to the clinic. Int J Hyperthermia 1994, 10:457–483.
Bolmsjö M, Wagrell L, Hallin A, et al.: The heat is on: But how? A comparison of TUMT devices. Br J Urol 1996, 78:564–572.
Bolmsjö M, Vrba J: Microwave applicators for thermotherapy of benign prostatic hyperplasia: a primer. Tech Urol 2000, 6:245–255. Noteworthy report.
Jung H: A generalized concept for cell killing by heat. Radiat Res 1986, 106:56–72.
Henriques FC: Studies of thermal injury. Arch Pathol 1947, 43:489–502.
Pennes HH: Analysis of tissue and arterial blood temperatures in the resting human forearm. J Appl Physiol 1948, 1:93–122.
Bolmsjö M, Schelin S, Wagrell L, et al.: Cell-kill modeling of microwave thermotherapy for treatment of benign prostatic hyperplasia. J Endourol 2000, 14:627–635. Noteworthy report.
Larson T, Collins J: An accurate technique for detailed prostatic interstitial temperature mapping in patients receiving microwave thermal treatment. J Endourol 1995, 9:339–347.
Huidobro C, Larson T, de la Rosette J, et al.: Temperature mapping, MRI and pathology: evaluation of ProstaLund microwave feedback thermotherapy. J Urol 2002, 167(suppl):365.
Wagrell L, Sundin A, Norlen BJ: Intraprostatic blood-flow changes during feedback microwave thermotherapy measured by positron emission tomography. J Endourol 1999, 13(suppl 1):A17.
Wagrell L, Schelin S, Bolmsjö M, Brudin L: Intraprostatic temperature monitoring during transurethral microwave thermotherapy for the treatment of benign prostatic hyperplasia. J Urol 1998, 159:1583–1587.
Wagrell L, Schelin S, Nordling J, et al.: Feedback microwave thermotherapy versus TURP for clinical BPH: a randomized controlled multi-center study. Urology 2002, 60:292–299. Noteworthy study of interest to clinicians.
Graber S: ProstaLund Feedback Thermotherapy versus TURP in BPH: a prospectively randomized study of a novel method in comparison to the standard treatment. J Urol 2002, 167(suppl):1444.
de la Rosette J: Prospective open study on ProstaLund feedback thermotherapy with 12-months results. J Endourol 2003, in press.
Schelin S: Microwave thermotherapy in patients with benign prostatic hyperplasia and chronic urinary retention. Eur Urol 2001, 39:400–404. Noteworthy report.
Schelin S: Mediating transurethral microwave thermotherapy by intraprostatic and periprostatic injections of mepivacaine epinephrine: effects on treatment time, energy consumption, and patient comfort. J Endourol 2002, 16:117–121. Interesting innovation.
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Larson, B.T., Bolmsj, M.B., Wagrell, L. et al. Prostalund feedback thermotherapy: A review. Curr Urol Rep 4, 292–296 (2003). https://doi.org/10.1007/s11934-003-0087-y
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DOI: https://doi.org/10.1007/s11934-003-0087-y