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Erectile dysfunction in the cardiac patient

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Abstract

Erectile dysfunction (ED) often is caused by endothelial dysfunction and may be a sign that a patient has vascular disease elsewhere in the body. Risk factors for coronary artery disease such as lipid abnormalities, smoking, diabetes, and hypertension also are risk factors for ED. Oral therapy for ED, such as sildenafil, inhibits phosphodiesterase-5 (PDE-5) and the breakdown of cyclic guanosine monophosphate. PDE-5 inhibitors have been shown to be safe and effective for the therapy for ED, but remain contraindicated in patients receiving organic nitrates. These agents are mild vasodilators and are being investigated for their treatment potential for patients with pulmonary hypertension, heart failure, and endothelial dysfunction.

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  1. Heart Institute, Good Samaritan Hospital, 1225 Wilshire Boulevard, 90017, Los Angeles, CA, USA

    Robert A. Kloner MD, PhD

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  1. Robert A. Kloner MD, PhD
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Kloner, R.A. Erectile dysfunction in the cardiac patient. Curr Urol Rep 4, 466–471 (2003). https://doi.org/10.1007/s11934-003-0028-9

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  • DOI: https://doi.org/10.1007/s11934-003-0028-9

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