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Vasoconstriction and vasodilation in erectile physiology

Current Urology Reports volume 3, pages 477–483 (2002)Cite this article

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Abstract

Recent studies have demonstrated that vasoconstriction in the erectile vasculature of the penis is mediated in part by RhoA/Rho-kinase signaling. However, this constrictor activity must be overcome to permit the vasodilation essential for erection. We hypothesize that the primary action of nitric oxide and other agents that cause penile erection is inhibition of the RhoA/Rho-kinase pathway, thereby allowing vasodilation and erection. This hypothesis, as well as experiments using hypogonadal and hypertensive animal models, are discussed in terms of the potential clinical value of Rho-kinase inhibitors for the treatment of erectile dysfunction.

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Authors and Affiliations

  1. Department of Physiology and Department of Surgery (Urology Section), Medical College of Georgia, 1120 15th Street, 30912-3000, Augusta, GA, USA

    Thomas M. Mills PhD

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  1. Thomas M. Mills PhD
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Mills, T.M. Vasoconstriction and vasodilation in erectile physiology. Curr Urol Rep 3, 477–483 (2002). https://doi.org/10.1007/s11934-002-0101-9

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  • DOI: https://doi.org/10.1007/s11934-002-0101-9

Keywords

  • Mean Arterial Pressure
  • Erectile Dysfunction
  • Vasoactive Intestinal Peptide
  • Rolipram
  • Penile Erection