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A novel method for the analysis of the androgen receptor

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Abstract

The role of the androgen receptor in the regulation of prostate cancer development and progression has been a focus of intense research. Until recent years, the level of expression of the androgen receptor protein was described qualitatively. Immunohistochemical parameters have been established that show a linear relationship between androgen receptor expression and immunostaining. Intensity of immunostaining can be accurately measured using computerassisted color video image analysis. Studies of progression and treatment of prostate cancer will benefit from the ability to quantitatively measure androgen receptor expression.

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Authors and Affiliations

  1. Department of Surgery, Division of Urology, University of North Carolina, CB# 7235, 27599-7235, Chapel Hill, NC, USA

    Kris E. Gaston MD, O. Harris Ford III, Swaroop Singh, Christopher W. Gregory PhD, Donald E. Weyel, Gary J. Smith MD & James L. Mohler MD

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  1. Kris E. Gaston MD
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  2. O. Harris Ford III
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  3. Swaroop Singh
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  4. Christopher W. Gregory PhD
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  6. Gary J. Smith MD
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  7. James L. Mohler MD
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Gaston, K.E., Harris Ford, O., Singh, S. et al. A novel method for the analysis of the androgen receptor. Curr Urol Rep 3, 67–74 (2002). https://doi.org/10.1007/s11934-002-0013-8

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