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Ribose: More than a simple sugar?

Abstract

This article reviews the current literature regarding the use of ribose as an ergogenic aid. Ribose manufacturers claim that it provides ergogenic benefit, but this has not been substantiated through scientific investigations. Data have shown promise that ribose supplementation leads to enhanced restoration of ATP levels following exercise, but this has seldom translated into increased athletic performance. However, as with many ergogenic aids, additional research is needed to clarify its value as a supplement.

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References and Recommended Reading

  1. 1.

    Nutrition Business Journal. New Hope Natural Media Online. Available at http://www.nutritionbusiness.com. Accessed May 29, 2007.

  2. 2.

    Schwirring L: Ribose: a rising star on the supplement scene? Phys Sportsmed 2001, 29:49–50.

  3. 3.

    PDRhealth. D-Ribose. Available at http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/dri_0226.shtml. Accessed May 16, 2007.

  4. 4.

    Hellsten-Westing Y, Norman B, Balsom PD, Sjodin B.: Decreased resting levels of a denine nucleotides in human skeletal muscle after high-intensity training. J Appl Physiol 1993, 74:2523–2528.

  5. 5.

    Zimmer HG: Restitution of myocardial adenine nucleotides: acceleration by administration of ribose. J Physiol 1980, 76:769–775.

  6. 6.

    Dodd SL, Johnson CA, Fernholz K, et al.: The role of ribose in human skeletal muscle metabolism. Med Hypotheses 2004, 62:819–824.

  7. 7.

    Hellsten Y, Skadhauge L, Bangsbo J: Effect of ribose supplementation in resynthesis of adenine nucleotides after intense intermittent training in hum ans. Am J Physiol Regul Integr Comp Physiol 2004, 286:R182–R188.

  8. 8.

    Pliml W, Von Arnim T, Stablein A, et al.: Effects of ribose on exercise-induced ischaemia in stable coronary artery disease. Lancet 1992, 340:507–510.

  9. 9.

    Peveler WW, Bishop PA, Whitehorn EJ: Effects of ribose as an ergogenic aid. J Strength Cond Res 2006, 20:519–522.

  10. 10.

    Mayo J, Blanton M, Taylor J, Hickey M: Effects of D-ribose supplementation on anaerobic exercise performance. Med Sci Sports Exerc 2004, 36:5171–5172.

  11. 11.

    Berardi JM, Ziengenfuss TN: Effects of ribose supplementation on repeated sprint perform ance in men. J Strength Cond Res 2003, 17:47–52.

  12. 12.

    Kreider RB, Melton C, Greenwood M, et al.: Effects of oral d-ribose supplementation on anaerobic capacity and selected metabolic markers in healthy males. Int J Nutr Exerc Metab 2003, 13:76–86.

  13. 13.

    Raue U, Gallagher PM, Williamson DL, et al.: The effects of ribose supplementation on perform ance during repeated high intensity cycle sprints. Med Sci Sports Exerc 2001, 33:544.

  14. 14.

    Op’t Eijnde B, Van Leemputte M, Brouns F, et al.: No effect of oral ribose supplementation on repeated maximal exercise and de novo ATP resynthesis. J Appl Physiol 2001, 91:2275–2281.

  15. 15.

    Dunne L, Worley S, Macknin M: Ribose versus dextrose supplementation, association with rowing performance. Clin J Sport Med 2006, 16:68–71.

  16. 16.

    Ramires PR, Forjaz CLM, Strunz CMC, et al.: Oral glucose ingestion increases endurance capacity on normal and diabetic (type 1) humans. J Appl Physiol 1997, 83:608–614.

  17. 17.

    Campbell SE, Angus DL, Febbraio MA.: Glucose kinetics and exercise performance during phases of the menstrual cycle: effect of glucose ingestion. Am J Physiol Endocrinol Metab 2001, 281:E816–E825.

  18. 18.

    Febbraio MA, Chiu A, Angus DJ, et al.: Effects of carbohydrate ingestion before and during exercise on glucose kinetics and performance. J Appl Physiol 2000, 89:2220–2226.

  19. 19.

    Van Gammeren D, Falk D, Antonio J: The effects of four weeks of ribose supplementation on body composition and exercise performance in healthy, young, male recreational body builders: a double-blind, placebo-controlled trial. Curr Ther Res 2002, 63:486–496.

  20. 20.

    Gross M, Reiter S, Zollner N: Metabolism of D-Riobose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1998, 67:1205–1213.

  21. 21.

    Pure Encapsulations. Available at http://www.purecaps.com/PDF/pi/Ribose.pdf. Accessed April 2007.

  22. 22.

    Rainbow Minerals. ATP Plus. Available at http://www.rainbowminerals.net/atp_info.htm Accessed May 16, 2007.

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Correspondence to Jeffrey A. Housner MD.

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Dhanoa, T.S., Housner, J.A. Ribose: More than a simple sugar?. Curr Sports Med Rep 6, 254–257 (2007). https://doi.org/10.1007/s11932-007-0041-8

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