Current Sports Medicine Reports

, Volume 6, Issue 4, pp 230–236 | Cite as

Omega-3 fatty acids and athletics

Article

Abstract

Human beings evolved consuming a diet that contained about equal amounts of ω-6 and ω-3 essential fatty acids. Today, in Western diets, the ratio of ω-6 to ω-3 fatty acids ranges from approximately 10:1 to 20:1 instead of the traditional range of 1:1 to 2:1. Studies indicate that a high intake of ω-6 fatty acids shifts the physiologic state to one that is prothrombotic and proaggregatory, characterized by increases in blood viscosity, vasospasm, and vasoconstriction, and decreases in bleeding time. ω-3 fatty acids, however, have anti-inflammatory, antithrombotic, antiarrhythmic, hypolipidemic, and vasodilatory properties. Excessive radical formation and trauma during high-intensity exercise leads to an inflammatory state that is made worse by the increased amount of ω-6 fatty acids in Western diets, although this can be counteracted by eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). For the majority of athletes, especially those at the leisure level, general guidelines should include EPA and DHA of about 1 to 2 g/d at a ratio of EPA:DHA of 2:1.

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References and Recommended Reading

  1. 1.
    Simopoulos AP: Genetic variation and dietary response: nutrigenetics/nutrigenomics. Asian Pacific J Clin Nutr 2002, 11(S6):S117–S128.CrossRefGoogle Scholar
  2. 2.
    Simopoulos AP: Genetics — implications for nutrition. Forum Nutr 2003, 56:226–229.PubMedGoogle Scholar
  3. 3.
    Simopoulos AP, Ordovas JM: Nutrigenetics and nutrigenomics. In World Review of Nutrition and Dietetics. Basel: Karger; 2004.Google Scholar
  4. 4.
    de Lorgeril M, Renaud S, Mamelle N, et al.: Mediterranean α-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 1994, 343:1454–1459.PubMedCrossRefGoogle Scholar
  5. 5.
    Marchioli R, Barzi F, Bomba E, et al.: Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction. Time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-Prevenzione. Circulation 2002, 105:1897–1903PubMedCrossRefGoogle Scholar
  6. 6.
    Iso H, Kobayashi K, Ishihara J, et al.: Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese. The Japan Public Health Center-Based (JPHC) Study Cohort I. Circulation 2006, 113:195–202.PubMedCrossRefGoogle Scholar
  7. 7.
    Simopoulos AP: Essential fatty acids in health and chronic disease. Am J Clin Nutr 1999, 70(3 Suppl):560S–569S.PubMedGoogle Scholar
  8. 8.
    Hibbeln JR, Davis JM, Steer C, et al.: Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study. Lancet 2007, 369:578–585.PubMedCrossRefGoogle Scholar
  9. 9.
    Simopoulos AP, Robinson J: The Omega Diet. The Lifesaving Nutritional Program Based on the Diet of the Island of Crete. New York: HarperCollins, 1999.Google Scholar
  10. 10.
    Simopoulos AP: Genetic variation and evolutionary aspects of diet. In Antioxidants in Nutrition and Health. Edited by Papas A. Boca Raton: CRC Press; 1999:65–88.Google Scholar
  11. 11.
    Simopoulos AP: The role of fatty acids in gene expression: health implications. Ann Nutr Metab 1996, 40:303–311.PubMedCrossRefGoogle Scholar
  12. 12.
    Eaton SB, Konner M: Paleolithic nutrition. A consideration of its nature and current implications. N Engl J Med 1985, 312:283–289.PubMedCrossRefGoogle Scholar
  13. 13.
    Simopoulos AP: Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 1991, 54:438–463.PubMedGoogle Scholar
  14. 14.
    Weber PC, Fischer S, von Schacky C, et al.: Dietary omega-3 polyunsaturated fatty acids and eicosanoid formation in man. In Health Effects of Polyunsaturated Fatty Acids in Seafoods. Edited by Simopoulos AP, Kifer RR, Martin RE. Orlando: Academic Press; 1986:49–60.Google Scholar
  15. 15.
    Lewis RA, Lee TH, Austen KF: Effects of omega-3 fatty acids on the generation of products of the 5-lipoxygenase pathway. In Health Effects of Polyunsaturated Fatty Acids in Seafoods. Edited by Simopoulos AP, Kifer RR, Martin RE. Orlando: Academic Press; 1986:227–238.Google Scholar
  16. 16.
    Brox JH, Killie JE, Osterud B, et al.: Effects of tod liver oil on platelets and coagulation in familial hypercholesterolemia (type IIa). Acta Med Scand 1983, 213:137–144.PubMedCrossRefGoogle Scholar
  17. 17.
    Joist JH, Baker RK, Schonfeld G: Increased invivo and in vitro platelet function in type II- and type IV-lyperlipoproteinemia. Thromb Res 1979, 15:95–108.PubMedCrossRefGoogle Scholar
  18. 18.
    Raheja BS, Sadikot SM, Phatak RB, Rao MB: Significance of the n-6/n-3 ratio for insulin action in diabetes. Ann N Y Acad Sci 1993, 683:258–271.PubMedCrossRefGoogle Scholar
  19. 19.
    Graber R, Sumida C, Nunez EA: Fatty acids and cell signal transduction. J Lipid Mediat Cell Signal 1994, 9:91–116.PubMedGoogle Scholar
  20. 20.
    Clarke SD, Jump DB: Dietary polyunsaturated fatty acid regulation of gene transcription. Annu Rev Nutr 1994, 14:83–98.PubMedCrossRefGoogle Scholar
  21. 21.
    Simopoulos AP: Proceedings of the First International Conference on Nutrition and Fitness. Am J Clin Nutr 1989, 49(Suppl):909–1124.Google Scholar
  22. 22.
    Simopoulos AP, Pavlou KN: Volume I. Nutrition and fitness for athletes. Proceedings of the Second International Conference on Nutrition and Fitness. In World Review of Nutrition and Dietetics, vol 71. Basel: Karger; 1993.Google Scholar
  23. 23.
    Simopoulos AP: Volume II. Nutrition and fitness in health and disease. Proceedings of the Second International Conference on Nutrition and Fitness. In World Review of Nutrition and Dietetics, vol 72. Basel: Karger, 1993.Google Scholar
  24. 24.
    Simopoulos AP: Volume I. Nutrition and fitness: evolutionary aspects, children’s health, policies and programs. Proceedings of the Third International Conference on Nutrition and Fitness. In World Review of Nutrition and Dietetics, vol. 81. Basel: Karger; 1997.Google Scholar
  25. 25.
    Simopoulos AP, Pavlou KN: Volume II. Nutrition and fitness: metabolic and behavioral aspects in health and disease. Proceedings of the Third International Conference on Nutrition and Fitness. In World Review of Nutrition and Dietetics, vol 82. Basel: Karger; 1997.Google Scholar
  26. 26.
    Simopoulos AP, Pavlou KN: Volume 1. Nutrition and fitness: diet, genes, physical activity and health Proceedings of the Fourth International Conference on Nutrition and Fitness. In World Review of Nutrition and Dietetics, vol 89. Basel: Karger; 2001.Google Scholar
  27. 27.
    Simopoulos AP, Pavlou KN: Volume 2. Nutrition and fitness: metabolic studies in health and disease. Proceedings of the Fourth International Conference on Nutrition and Fitness. In World Review of Nutrition and Dietetics, vol 89. Basel: Karger; 2001.Google Scholar
  28. 28.
    Simopoulos AP: Volume I. Nutrition and fitness: obesity, the metabolic syndrome, cardiovascular disease, and cancer. Proceedings of the Fifth International Conference on Nutrition and Fitness. In World Review of Nutrition and Dietetics, vol 94. Basel: Karger; 2005.Google Scholar
  29. 29.
    Simopoulos AP: Volume II. Nutrition and fitness: mental health, aging, and the implementation of a health diet and physical activity lifestyle. Proceedings of the Fifth International Conference on Nutrition and Fitness. In World Review of Nutrition and Dietetics, vol 95. Basel: Karger, 2005.Google Scholar
  30. 30.
    Peoples GE, McLennan PL, Howe PRC, Groeller H: Fish oil reduces apparent myocardial oxygen consumption in trained cyclists but does not change time to fatigue. Presented at the Fourth International Conference on Nutrition and Fitness. Athens: May 25–29, 2000.Google Scholar
  31. 31.
    Hwalla N, Sibai MA, Adra N: Adolescent obesity and physical activity. World Rev Nutr Diet 2005, 94:42–50.PubMedCrossRefGoogle Scholar
  32. 32.
    Karlsson J: Exercise, muscle metabolism and the antioxidant defense. World Rev Nutr Diet 1997, 82:81–100.PubMedCrossRefGoogle Scholar
  33. 33.
    Goransson U, Karlson J, Ronneberg R, et al.: The “Are” sport nutratherapy program: the rationale for food supplements in sports medicine. World Rev Nutr Diet 1997, 82:101–121.PubMedCrossRefGoogle Scholar
  34. 34.
    McMurchie EJ, Margetts BM, Beilin LJ, et al.: Dietary-induced changes in the fatty acid composition of human cheek cell phospholipids: correlation with changes in the dietary polyunsaturated/saturated fat ratio. Am J Clin Nutr 1996, 39:975–980.Google Scholar
  35. 35.
    Storlien LH, Baur LA, Kriketos AD, et al.: Dietary fats and insulin action. Diabetologia 1996, 39:621–631.PubMedCrossRefGoogle Scholar
  36. 36.
    Borkman M, Storlien LH, Pan DA, et al.: The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. New Engl J Med 1993, 328:238–244.PubMedCrossRefGoogle Scholar
  37. 37.
    Andersson A, Sjodin A, Olsson R, Vessby B: Effects of physical exercise on phospholipid fatty acid composition in skeletal muscle. Am J Physiol Endocrinol Metab 1998, 274:E432–E438.Google Scholar
  38. 38.
    Helge JW, Wu BJ, Willer M, et al.: Training affects muscle phospholipid fatty acid composition in humans. J Appl Physiol 2001, 90:670–677.PubMedCrossRefGoogle Scholar
  39. 39.
    Dela F, Mikines KJ, Sonne B, Galbo H: Effect of training on interaction between insulin and exercise in human muscle. J Appl Physiol 1994, 76:2386–2393.PubMedGoogle Scholar
  40. 40.
    Koivisto VA, Yki-Järvinen H, DeFronzo RA: Physical training and insulin sensitivity. Diabetes Metab Rev 1986, 1:445–481.PubMedCrossRefGoogle Scholar
  41. 41.
    Mikines K, Sonne B, Farrell P, et al.: Effect of physical exercise on sensitivity and responsiveness to insulin in humans. Am J Physiol Endocrinol Metab 1988, 254:E248–E259.Google Scholar
  42. 42.
    Morgan TE, Short FA, Cobb LA: Effect of long-term exercise on skeletal muscle lipid composition. Am J Physiol 1969, 216:82–88.PubMedGoogle Scholar
  43. 43.
    Gorski J, Zendzian-Piotrowska M, de Jong YF, et al.: Effect of endurance training on the phospholipid content of skeletal muscle in the rat. Eur J Appl Physiol 1999, 79:421–425.CrossRefGoogle Scholar
  44. 44.
    Gudbjarnason S: Dynamics of n-3 and n-6 fatty acids in phospholipids of heart muscle. J Int Med 1989, 225(Suppl 1):117–128.Google Scholar
  45. 45.
    Kiens B, Essen-Gustavsson B, Christensen NJ, Saltin B: Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training. J Physiol (Lond) 1993, 469:459–478.Google Scholar
  46. 46.
    Walser B, Giordano RM, Stebbins CL: Supplementation with omega-3 polyunsaturated fatty acids augments brachial artery dilation and blood flow during forearm contraction. Eur J Appl Physiol 2006, 97:347–354.PubMedCrossRefGoogle Scholar
  47. 47.
    McFadden ER, Lenner KAM, Strohl KP: Postexertional airway rewarming and thermally induced asthma. J Clin Invest 1986, 78:18–25.PubMedCrossRefGoogle Scholar
  48. 48.
    Anderson SD, Schoeffel RE, Black JL, Daviskas E: Airway cooling in the stimulus to exercise-induced asthma: a reevaluation. Eur J Respir Dis 1985, 67:20–30.PubMedGoogle Scholar
  49. 49.
    Davis MS, Freed AN: Repetitive hyperpnoea causes peripheral airway obstruction and eosinophilia. Eur Respir J 1999, 14:57–62.PubMedCrossRefGoogle Scholar
  50. 50.
    Sue-Chu M, Karjalainen EM, Laitinen A, et al.: Placebo-controlled study of inhaled budesonide on indices of airway inflammation in bronchoalveolar lavage fluid and bronchial biopsies in cross-country skiers. Respiration (Herrlisheim) 2000, 67:417–425.CrossRefGoogle Scholar
  51. 51.
    Mickleborough TD, Murray RL, Ionescu AA, Lindley MR: Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes, Am J Respir Crit Care Med 2003, 168:1181–1189.PubMedCrossRefGoogle Scholar

Copyright information

© Current Medicine Group LLC 2007

Authors and Affiliations

  1. 1.The Center for Genetics, Nutrition and HealthWashington, DCUSA

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