Neurologic and neuroendocrinologic responses during orgasm: What do we know?


In recent decades, progress has been made in terms of understanding the neurologic and neuroendocrinologic control of sexual function, particularly orgasm. This has been achieved primarily with rodent animal models in which the physical (autonomic and somatic) changes observed during orgasmic reflexes are similar to those reported in humans. More recently, imaging studies in men and women have examined the brain regions activated with sexual stimulation and these observations correlate well with data from animal studies. This paper discusses what is known about the central nervous system regions and neurotransmitters involved in orgasmic-like responses in men and women.

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References and Recommended Reading

  1. 1.

    Giuliano F, Clement P: Neuroanatomy and physiology of ejaculation. Annu Rev Sex Res 2005, 16:190–216.

    PubMed  Google Scholar 

  2. 2.

    Sipski ML, Behnegar A: Neurogenic female sexual dysfunction: a review. Clin Auton Res 2001, 11:279–283.

    PubMed  Article  CAS  Google Scholar 

  3. 3.

    Meston CM, Levin RJ, Sipski ML, et al.: Women’s orgasm. Annu Rev Sex Res 2004, 15:173–257.

    PubMed  Google Scholar 

  4. 4.

    Bohlen JG, Held JP, Sanderson MO: The male orgasm: pelvic contractions measured by anal probe. Arch Sex Behav 1980, 9:503–521.

    PubMed  Article  CAS  Google Scholar 

  5. 5.

    Bohlen JG, Held JP, Sanderson MO, Ahlgren A: The female orgasm: pelvic contractions. Arch Sex Behav 1982, 11:367–386.

    PubMed  Article  CAS  Google Scholar 

  6. 6.

    Motofei IG, Rowland DL: Neurophysiology of the ejaculatory process: developing perspectives. BJU Int 2005, 96:1333–1338.

    PubMed  Article  CAS  Google Scholar 

  7. 7.

    McKenna KE, Marson L: Spinal and brainstem control of sexual function. In Central Control of Autonomic Function. Edited by Jordan D. Amsterdam: Harwood Academic Publishers; 1997:151–187.

    Google Scholar 

  8. 8.

    Karama S, Lecours AR, Leroux JM, et al.: Areas of brain activation in males and females during viewing of erotic film excerpts. Hum Brain Mapp 2002; 16:1–13.

    PubMed  Article  Google Scholar 

  9. 9.

    Georgiadis JR, Kortekaas R, Kuipers R, et al.: Regional cerebral blood flow changes associated with clitorally induced orgasm in healthy women. Eur J Neurosci 2006, 24:3305–3316.

    PubMed  Article  Google Scholar 

  10. 10.

    Bianchi-Demicheli F, Ortigue S: Toward an understanding of the cerebral substrates of woman’s orgasm. Neuropsychologia 2007, 45:2645–2659.

    PubMed  Article  Google Scholar 

  11. 11.

    Georgiadis JR, Reinders AA, Van der Graaf FH, et al.: Brain activation during human male ejaculation revisited. Neuroreport 2007, 18:553–557.

    PubMed  Article  Google Scholar 

  12. 12.

    Mallick HN, Tandon S, Jagannathan NR, et al.: Brain areas activated after ejaculation in healthy young human subjects. Indian J Physiol Pharmacol 2007, 51:81–85.

    PubMed  CAS  Google Scholar 

  13. 13.

    Ortigue S, Grafton ST, Bianchi-Demicheli F: Correlation between insula activation and self-reported quality of orgasm in women. Neuroimage 2007, 37:551–560.

    PubMed  Article  Google Scholar 

  14. 14.

    Komisaruk BR, Whipple B, Crawford A, et al.: Brain activation during vaginocervical self-stimulation and orgasm in women with complete spinal cord injury: fMRI evidence of mediation by the vagus nerves. Brain Res 2004, 1024:77–88.

    PubMed  Article  CAS  Google Scholar 

  15. 15.

    Giraldi A, Marson L, Nappi R, et al.: Physiology of female sexual function: animal models. J Sex Med 2004, 1:237–253.

    PubMed  Article  CAS  Google Scholar 

  16. 16.

    Rowland DL: Neurobiology of sexual response in men and women. CNS Spectr 2006, 11(8 Suppl 9):6–12.

    PubMed  Google Scholar 

  17. 17.

    Marson L, McKenna KE: The identification of a brainstem site controlling spinal sexual reflexes in male rats. Brain Res 1990, 515:303–308.

    PubMed  Article  CAS  Google Scholar 

  18. 18.

    Marson L, McKenna KE: Stimulation of the hypothalamus initiates the urethrogenital reflex in male rats. Brain Res 1994, 638:103–108.

    PubMed  Article  CAS  Google Scholar 

  19. 19.

    Marson L, Foley KA: Identification of neural pathways involved in genital reflexes in the female: a combined anterograde and retrograde tracing study. Neuroscience 2004, 127:723–736.

    PubMed  Article  CAS  Google Scholar 

  20. 20.

    McKenna KE, Chung SK, McVary KT: A model for the study of sexual function in anesthetized male and female rats. Am J Physiol 1991, 261:R1276–R1285.

    PubMed  CAS  Google Scholar 

  21. 21.

    Marson L: Central nervous system neurons identified after injection of pseudorabies virus into the rat clitoris. Neurosci Lett 1995, 190:41–44.

    PubMed  Article  CAS  Google Scholar 

  22. 22.

    Marson L, Carson 3rd CC: Central nervous system innervation of the penis, prostate, and perineal muscles: a transneuronal tracing study. Mol Urol 1999, 3:43–50.

    PubMed  Google Scholar 

  23. 23.

    Marson L, Cai R, Makhanova N: Identification of spinal neurons involved in the urethrogenital reflex in the female rat. J Comp Neurol 2003, 462:355–370.

    PubMed  Article  Google Scholar 

  24. 24.

    Marson L, Gravitt K: Spinal neurons activated with the urethrogenital reflex in the male rat. Brain Res 2004, 1026:108–115.

    PubMed  Article  CAS  Google Scholar 

  25. 25.

    Coolen LM, Peters HJ, Veening JG: Fos immunoreactivity in the rat brain following consummatory elements of sexual behavior: a sex comparison. Brain Res 1996, 738:67–82.

    PubMed  Article  Google Scholar 

  26. 26.

    Veening JG, Coolen LM: Neural activation following sexual behavior in the male and female rat brain. Behav Brain Res 1998, 92:181–193.

    PubMed  Article  CAS  Google Scholar 

  27. 27.

    Hamson DK, Watson NV: Regional brainstem expression of Fos associated with sexual behavior in male rats. Brain Res 2004, 1006:233–240.

    PubMed  Article  CAS  Google Scholar 

  28. 28.

    Hull EM, Dominguez JM: Sexual behavior in male rodents. Horm Behav 2007, 52:45–55.

    PubMed  Article  CAS  Google Scholar 

  29. 29.

    Giuliano F, Allard J, Compagnie S, et al.: Vaginal physiological changes in a model of sexual arousal in anesthetized rats. Am J Physiol Regul Integr Comp Physiol 2001, 281:R140–R149.

    PubMed  CAS  Google Scholar 

  30. 30.

    Coolen LM, Veening JG, Petersen DW, Shipley MT: Parvocellular subparafascicular thalamic nucleus in the rat: anatomical and functional compartmentalization. J Comp Neurol 2003, 463:117–131.

    PubMed  Article  Google Scholar 

  31. 31.

    Sipski ML, Alexander CJ, Rosen R: Sexual arousal and orgasm in women: effects of spinal cord injury. Ann Neurol 2001, 49:35–44.

    PubMed  Article  CAS  Google Scholar 

  32. 32.

    Sipski M, Alexander C, Gomez-Marin O, Spalding J: The effects of spinal cord injury on psychogenic sexual arousal in males. J Urol 2007, 177:247–251.

    PubMed  Article  Google Scholar 

  33. 33.

    Allard J, Truitt WA, McKenna KE, Coolen LM: Spinal cord control of ejaculation. World J Urol 2005, 23:119–126.

    PubMed  Article  Google Scholar 

  34. 34.

    Modell JG, Katholi CR, Modell JD, DePalma RL: Comparative sexual side effects of bupropion, fluoxetine, paroxetine, and sertraline. Clin Pharmacol Ther 1997, 61:476–487.

    PubMed  CAS  Article  Google Scholar 

  35. 35.

    de Jong TR, Pattij T, Veening JG, et al.: Effects of chronic selective serotonin reuptake inhibitors on 8-OH-DPAT-induced facilitation of ejaculation in rats: comparison of fluvoxamine and paroxetine. Psychopharmacology (Berl) 2005, 179:509–515.

    Article  CAS  Google Scholar 

  36. 36.

    de Jong TR, Veening JG, Waldinger MD, et al.: Serotonin and the neurobiology of the ejaculatory threshold. Neurosci Biobehav Rev 2006, 30:893–907.

    PubMed  Article  CAS  Google Scholar 

  37. 37.

    Dominguez JM, Hull EM: Dopamine, the medial preoptic area, and male sexual behavior. Physiol Behav 2005, 86:356–368.

    PubMed  Article  CAS  Google Scholar 

  38. 38.

    Clement P, Bernabe J, Denys P, et al.: Ejaculation induced by i.c.v. injection of the preferential dopamine D(3) receptor agonist 7-hydroxy-2-(di-N-propylamino)tetralin in anesthetized rats. Neuroscience 2007, 145:605–610.

    PubMed  Article  CAS  Google Scholar 

  39. 39.

    Kroeger M: Oxytocin: key hormone in sexual intercourse, parturition, and lactation. Birth Gaz 1996, 13:28–30.

    PubMed  CAS  Google Scholar 

  40. 40.

    Pedersen CA, Boccia ML: Oxytocin maintains as well as initiates female sexual behavior: effects of a highly selective oxytocin antagonist. Horm Behav 2002, 41:170–177.

    PubMed  Article  CAS  Google Scholar 

  41. 41.

    Argiolas A, Melis MR: Central control of penile erection: role of the paraventricular nucleus of the hypothalamus. Prog Neurobiol 2005, 76:1–21.

    PubMed  Article  CAS  Google Scholar 

  42. 42.

    Bancroft J: The endocrinology of sexual arousal. J Endocrinol 2005, 186:411–427.

    PubMed  Article  CAS  Google Scholar 

  43. 43.

    Kita I, Yoshida Y, Nishino S: An activation of parvocellular oxytocinergic neurons in the paraventricular nucleus in oxytocin-induced yawning and penile erection. Neurosci Res 2006, 54:269–275.

    PubMed  Article  CAS  Google Scholar 

  44. 44.

    Exton MS, Kruger TH, Koch M, et al.: Coitus-induced orgasm stimulates prolactin secretion in healthy subjects. Psychoneuroendocrinology 2001, 26:287–294.

    PubMed  Article  CAS  Google Scholar 

  45. 45.

    Kruger TH, Schiffer B, Eikermann M, et al.: Serial neurochemical measurement of cerebrospinal fluid during the human sexual response cycle. Eur J Neurosci 2006, 24:3445–3452.

    PubMed  Article  Google Scholar 

  46. 46.

    Brody S, Kruger TH: The post-orgasmic prolactin increase following intercourse is greater than following masturbation and suggests greater satiety. Biol Psychol 2006, 71:312–315.

    PubMed  Article  Google Scholar 

  47. 47.

    Pfaus J, Giuliano F, Gelez H: Bremelanotide: an overview of preclinical CNS effects on female sexual function. J Sex Med 2007, 4(Suppl 4):269–279.

    PubMed  Article  CAS  Google Scholar 

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Correspondence to Lesley Marson.

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Marson, L. Neurologic and neuroendocrinologic responses during orgasm: What do we know?. Curr sex health rep 5, 141 (2008).

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  • Sexual Behavior
  • Sexual Function
  • Oxytocin
  • Ventral Tegmental Area
  • Sexual Arousal