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Models for the study of priapism

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Abstract

Ischemic priapism is a distressing condition that frequently results in severe organic erectile dysfunction in young men. Various models for studying this disorder have enabled several advances in the understanding of priapism over the past few years. Researchers are slowly discovering the contributions of metabolic and cellular components of ischemia to cavernosal smooth muscle failure. In addition, the etiology of recurrent priapism in men susceptible to the disease is becoming clear.

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References and Recommended Reading

  1. Kulmala RV, Lehtonen TA, Tammela TL: Priapism, its incidence and seasonal distribution in Finland. Scand J Urol Nephrol 1995, 29:93–96.

    PubMed  CAS  Google Scholar 

  2. Eland IA, van der Lei J, Stricker BH, Sturkenboom MJ: Incidence of priapism in the general population. Urology 2001, 57:970–972.

    Article  PubMed  CAS  Google Scholar 

  3. Kulmala RV, Lehtonen TA, Tammela TL: Preservation of potency after treatment for priapism. Scand J Urol Nephrol 1996, 30:313–316.

    PubMed  CAS  Google Scholar 

  4. Montague DK, Jarow J, Broderick GA, et al.: American Urological Association guideline on the management of priapism. J Urol 2003, 170(Suppl 4 Pt 1):1318–1324. This systematic review of the literature includes recommendations for the stepwise management of priapism.

    Article  PubMed  Google Scholar 

  5. Pryor J, Akkus E, Alter G, et al.: Priapism. J Sex Med 2004, 1:116–120. This paper is another systematic review with recommendations for the management of priapism.

    Article  PubMed  Google Scholar 

  6. Ciampalini S, Savoca G, Buttazzi L, et al.: High-flow priapism: treatment and long-term follow-up. Urology 2002, 59(1):110–113.

    Article  PubMed  Google Scholar 

  7. Juenemann KP, Lue TF, Abozeid M, et al.: Blood gas analysis in drug-induced penile erection. Urol Int 1986, 41:207–211.

    PubMed  CAS  Google Scholar 

  8. Broderick GA, Harkaway R: Pharmacologic erection: timedependent changes in the corporal environment. Int J Impot Res 1994, 6:9–16.

    PubMed  CAS  Google Scholar 

  9. Broderick GA, Gordon D, Hypolite J, Levin RM: Anoxia and corporal smooth muscle dysfunction: a model for ischemic priapism. J Urol 1994, 151:259–262.

    PubMed  CAS  Google Scholar 

  10. Kim NN, Kim JJ, Hypolite J, et al.: Altered contractility of rabbit penile corpus cavernosum smooth muscle by hypoxia. J Urol 1996, 155:772–778.

    Article  PubMed  CAS  Google Scholar 

  11. Saenz de Tjada I, Kim NN, Daley JT, et al.: Acidosis impairs rabbit trabecular smooth muscle contractility. J Urol 1997, 157:722–726.

    Article  Google Scholar 

  12. Moon DG, Lee DS, Kim JJ: Altered contractile response of penis under hypoxia with metabolic acidosis. Int J Impot Res 1999, 11:265–271.

    Article  PubMed  CAS  Google Scholar 

  13. Muneer A, Cellek S, Dogan A, et al.: Investigation of cavernosal smooth muscle dysfunction in low flow priapism using an in vitro model. Int J Impot Res 2005, 17:10–18. This paper examines the effects of the components of simulated ischemia, separately and in combination, on CSM using an in vitro model. The authors evaluate the effect of ischemia and reperfusion on both nerve-mediated and agonist-induced contraction.

    Article  PubMed  CAS  Google Scholar 

  14. Munarriz R, Park K, Huang YH, et al.: Reperfusion of ischemic corporal tissue: physiologic and biochemical changes in an animal model of ischemic priapism. Urology 2003, 62:760–764. These authors show the detrimental effect of reperfusion on cavernosal tissues using an in vivo model. Ultrastructural changes are demonstrated, indicating tissue damage both during and upon resolution of an episode of priapism.

    Article  PubMed  Google Scholar 

  15. Moreland RB: Is there a role of hypoxemia in penile fibrosis: a viewpoint presented to the Society for the Study of Impotence. Int J Impot Res 1998, 10:113–120.

    Article  PubMed  CAS  Google Scholar 

  16. Nehra A, Gettman MT, Nugent M, et al.: Transforming growth factor-beta1 (TGF-beta1) is sufficient to induce fibrosis of rabbit corpus cavernosum in vivo. J Urol 1999, 162(Suppl 3 Pt 1):910–5.

    Article  PubMed  CAS  Google Scholar 

  17. Ul-Hasan M, El-Sakka AI, Lee C, et al.: Expression of TGF-beta-1 mRNA and ultrastructural alterations in pharmacologically induced prolonged penile erection in a canine model. J Urol 1998, 160(Suppl 6 Pt 1):2263–2266.

    Article  PubMed  CAS  Google Scholar 

  18. Sanli O, Armagan A, Kandirali E, et al.: TGF-beta1 neutralizing antibodies decrease the fibrotic effects of ischemic priapism. Int J Impot Res 2004, 16:492–497. These authors use an in vivo model to demonstrate the role of cytokines and compounds that modify cytokine behavior on cavernosal fibrosis following ischemic priapism.

    Article  PubMed  CAS  Google Scholar 

  19. Adeyoju AB, Olujohungbe AB, Morris J, et al.: Priapism in sickle-cell disease; incidence, risk factors and complications: an international multicentre study. BJU Int 2002, 90:898–902.

    Article  PubMed  CAS  Google Scholar 

  20. Lin G, Xin ZC, Lue TF, Lin CS: Up and down-regulation of phosphodiesterase-5 as related to tachyphylaxis and priapism. J Urol 2003, 170(Suppl 2 Pt 2):S15-S18. This paper discusses an isolated CSM cell model showing alterations in factors mediating smooth muscle contractile mechanism in response to hypoxia.

    Article  PubMed  Google Scholar 

  21. Champion HC, Bivalacqua TJ, Takimoto E, et al.: dysregulation in penile erectile tissue is a mechanism of priapism. Proc Natl Acad Sci U S A 2005, 102:1661–1666. This article shows the link between eNOS and the functional expression of the downstream regulator of contraction-inducing PDE5. The authors explore gene transfer as one of the possible therapeutic options.

    Article  PubMed  CAS  Google Scholar 

  22. Burnett AL, Chang AG, Crone JK, et al.: Noncholinergic penile erection in mice lacking the gene for endothelial nitric oxide synthase. J Androl 2002, 23:92–97.

    PubMed  CAS  Google Scholar 

  23. Beuzard Y: Transgenic mouse models of sickle cell disease. Curr Opin Hematol 1996, 3:150–155.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to David J. Ralph MS, FRCS (Urology).

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Kumar, P., Minhas, S. & Ralph, D.J. Models for the study of priapism. Curr sex health rep 3, 151–153 (2006). https://doi.org/10.1007/s11930-006-0004-8

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  • DOI: https://doi.org/10.1007/s11930-006-0004-8

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