Current Rheumatology Reports

, Volume 1, Issue 2, pp 139–148 | Cite as

Animal models of rheumatoid arthritis and related inflammation

  • Bina Joe
  • Marie M. Griffiths
  • Elaine F. Remmers
  • Ronald L. Wilder

Abstract

The major, extensively studied, experimentally-induced rat and mouse models of arthritis with features resembling rheumatoid arthritis are reviewed here. Etiopathogenetic studies that were recently published are emphasized. In summary, multiple triggering stimuli can induce disease in genetically-prone strains of inbred rats and mice. Multiple genetic loci, including both MHC and non-MHC, regulate disease expression in these animals. By comparison with other models of autoimmune disease, clustering of regulatory loci within and among species is increasingly becoming evident. At the cellular level, both innate and acquired immune systems are involved in the disease manifestations. At the molecular level, unbalanced chronic production of tumor necrosis factor-a (TNF-a), interleukin (IL)-1, IL-6 and IL-12, as opposed to IL-4 and IL-10, is correlated with arthritis disease susceptibility and severity.

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Copyright information

© Current Science Inc 1999

Authors and Affiliations

  • Bina Joe
    • 1
  • Marie M. Griffiths
    • 2
  • Elaine F. Remmers
    • 1
  • Ronald L. Wilder
    • 1
  1. 1.Inflammatory Joint Diseases Section, Arthritis and Rheumatism BranchNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of HealthBethesdaUSA
  2. 2.Research Service, Veterans Affairs Medical Center and Department of Medicine/RheumatologyUniversity of UtahSalt Lake CityUSA

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