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Initial management of proliferative lupus nephritis: To cytotoxic or not to cytotoxic?

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References

  1. Austin Ha, Klippel JH, Balow JE, et al.: The Therapy of lupus nephritis: controlled trial of prednisone and cytotoxic drugs. N Eng J Med 1986, 314:614–619.

    Article  Google Scholar 

  2. Boumpas DT, Austin HA III, Vaughn EM, et al.: Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis. Lancet 1992, 340:741–745.

    Article  PubMed  CAS  Google Scholar 

  3. Belmont HM, Storch M, Buyon J, Abramson S: New York University/Hospital for Joint Diseases experience with intra-venous cyclophosphamide treatment: efficacy in steroid unresponsive lupus nephritis. Lupus 1995, 4:104–108.

    PubMed  CAS  Google Scholar 

  4. Pistiner M, Wallace DJ, Nessim S, et al.: Lupus erythematosus in the 1980s: a surey of 570 patients. Semin Rheum Dis 1991, 21:55–64.

    Article  CAS  Google Scholar 

  5. McCune WJ, Golbus J, Zeldes W, et al.: Clinical and immuno-logic effects of monthly administration of intravenous cyclophosphamide in severe systemic lupus erythematosus. N Eng J Med 1988, 318:1423–1451.

    Article  CAS  Google Scholar 

  6. Du LTH, Piette JC, Faucher C, et al.: Efficacy and limits of intra-venous cyclophosphamide (IVCP) in systemic lupus erythe-matosus (SLE): an open study in 45 cases [abstract]. Arthritis Rheum 1991, 34:S58.

    Google Scholar 

  7. Lehman TJA, Sherry DD, Wagner-Weiner L, et al.: Intermittent intravenous cyclophosphamide for lupus nephritis. J Pediatr 1989, 114:1055–1060.

    Article  PubMed  CAS  Google Scholar 

  8. Wagner-Weiner L, Emery H, Spencer C, et al.: Intravenous pulse cyclophosphamide therapy (IVCY) for childhood lupus nephritis: variable renal outcomes at 3 to 7 year follow-up [abstract]. Arthritis Rheum 1991, 34:S58.

    Article  Google Scholar 

  9. Gourley MF, Austin HA, Scott D, et al.: Methylprednisolone and cyclophosphamide, alone or in combination, in patients with lupus nephritis. Ann Intern Med 1997, 125:549–557.

    Google Scholar 

  10. Felson DT, Anderson J: Evidence for the superiority of immuno-suppresive drugs and prednisone over prednisone alone in lupus nephritis: results of a pooled analysis. N Eng J Med 1984, 311:1528–1533.

    Article  CAS  Google Scholar 

  11. Bansal VK, Beto JA: Treatment of lupus nephritis: a meta-analysis of clinical trials. Am J Kidney Dis 1997, 29:193–199.

    PubMed  CAS  Google Scholar 

  12. Steinberg AD, Steinberg SC: Long-term preservation of renal function in patients with lupus nephritis receiving treatment that includes cyclophosphamide versus those treated with prednisone alone. Arthritis Rheum 1991, 34:945–950.

    Article  PubMed  CAS  Google Scholar 

  13. Briggs WA, Choi MJ, Schesel PJ Jr: Successful mycophenolate mofetil treatment of glomerular diseases. Am J Kidney Dis 1998, 41:S110.

    Google Scholar 

  14. Pashinian N, Wallace D, Klineneberg JR: Mycophenolate mofetil for systemic lupus erythematosus. Arthritis Rheum 1998, 41:S110.

    Article  Google Scholar 

  15. Lewis EJ, Hunsicker LG, Lan SP, et al.: A controlled trial of plasmapheresis therapy in severe lupus nephritis. N Eng J Med 1992, 326:1373–1379.

    Article  CAS  Google Scholar 

  16. Euler HH, Gutschmidt HJ, Schmuecking M, et al.: Induction of remission in severe SLE after plasma exchange synchronized with subsequent pulse cyclophosphamide. Prog Clin Biol Res 1990, 337:319–320.

    PubMed  CAS  Google Scholar 

  17. Wallace D, Goldfinger D, Pepkowitz S: A prospective, con-trolled trial of pulse synchronization cyclophosphamide (CTX)/apheresis for proliferative lupus nephritis [abstract]. Arthritis Rheum 1997, 40:S58.

    Google Scholar 

  18. Schroeder JO, Schwab U, Zeuner R, et al.: Plasmapheresis and subsequent pulse cyclophosphamide in severe systemic lupus erythematosus. Arthritis Rheum 1997, 40:S325.

    Google Scholar 

  19. Marmont AM: Intense immunosuppression and stem cell transplantation or rescue for severe systemic lupus erythema-tosus. Lupus 1999, 8:256–257.

    Article  PubMed  CAS  Google Scholar 

  20. Brodsky RA, Petri M, Smith BD, et al.: Immunoablative high-dose cyclophosphamide without stem-cell rescue for refractory severe autoimmune disease. Ann Intern Med 1998, 129:1031–1035.

    PubMed  CAS  Google Scholar 

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Belmont, H.M. Initial management of proliferative lupus nephritis: To cytotoxic or not to cytotoxic?. Curr Rheumatol Rep 1, 87–88 (1999). https://doi.org/10.1007/s11926-999-0001-9

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