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Insights into the role of infection in the spondyloarthropathies

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Abstract

Certain infections play an important role in the pathogenesis of the human leukocyte antigen (HLA)-B27-associated reactive arthritis. Whether infections play a role in other forms of spondyloarthropathies is not as clear. The role of HLA-B27 as an antigen-presenting molecule is important in the pathogenesis of these diseases. Recent evidence has been obtained indicating that this molecule may have other functions unrelated to antigen-presentation in the interaction of reactive arthritis-triggering microbes and host. This paper reviews the recent studies on the role of infection in the spondyloarthropathies.

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  1. Department in Turku, National Public Health Institute, Kiinamyllynkatu 13, FIN-20520, Turku, Finland

    Yi Liu MD, Markus A. Penttinen MD & Kaisa Granfors PhD

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Liu, Y., Penttinen, M.A. & Granfors, K. Insights into the role of infection in the spondyloarthropathies. Curr Rheumatol Rep 3, 428–434 (2001). https://doi.org/10.1007/s11926-996-0014-6

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