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What to Know About Biopsy Sampling and Pathology in Vasculitis?

  • Vasculitis (C Dejaco and C Duftner, Section Editors)
  • Published:
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Abstract

Purpose of Review

To summarize the histologic findings of vasculitis, and to give some practical considerations on biopsy samples.

Recent Findings

The larger use of imaging and the discoveries of serological markers in the diagnosis of vasculitis have increased the clinical recognition of these entities. Nevertheless, biopsy remains the gold standard for diagnosis in most cases. So far, biopsies are also useful to obtain information about prognosis and to guide a more specific treatment. In recent years, less invasive diagnostic approaches have become available, lowering the risks related to the procedure and permitting a definite diagnosis in most cases.

Summary

Histological examination permits a definite diagnosis of vasculitis. However, the findings may be nonspecific if not evaluated in the proper clinical setting. The interaction between clinicians and pathologists is crucial to obtain a definite diagnosis.

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  1. Chiara Marvisi and Francesco Muratore contributed equally to this manuscript

Authors and Affiliations

  1. Rheumatology Unit, Azienda Unità Sanitaria Locale-IRCCS Di Reggio Emilia, Viale Risorgimento 80, 42123, Reggio Emilia, Italy

    Chiara Marvisi, Francesco Muratore, Chiara Cabassi, Elena Galli, Luigi Boiardi & Carlo Salvarani

  2. Rheumatology Unit, University of Modena and Reggio Emilia, Modena, Italy

    Chiara Marvisi, Chiara Cabassi, Elena Galli & Carlo Salvarani

  3. Pathology Unit, Azienda Unità Sanitaria Locale-IRCCS Di Reggio Emilia, Reggio Emilia, Italy

    Simonetta Piana, Maria Cecilia Mengoli & Alberto Cavazza

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  1. Chiara Marvisi
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Marvisi, C., Muratore, F., Cabassi, C. et al. What to Know About Biopsy Sampling and Pathology in Vasculitis?. Curr Rheumatol Rep 24, 279–291 (2022). https://doi.org/10.1007/s11926-022-01082-6

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