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Intersections Between Mitochondrial Metabolism and Redox Biology Mediate Posttraumatic Osteoarthritis

  • Osteoarthritis (MB Goldring and T Griffin, Section Editors)
  • Published:
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Abstract

Purpose of Review

This review will cover foundational studies and recent findings that established key concepts for understanding the importance of redox biology to chondrocyte mitochondrial function and osteoarthritis pathophysiology after injury.

Recent Findings

Articular chondrocyte mitochondria can be protected with a wide variety of antioxidants that will be discussed within a framework suggested by classic studies. These agents not only underscore the importance of thiol metabolism and associated redox function for chondrocyte mitochondria but also suggest complex interactions with signal transduction pathways and other molecular features of osteoarthritis that require more thorough investigation. Emerging evidence also indicates that reductive stress could occur alongside oxidative stress.

Summary

Recent studies have shed new light on historic paradoxes in chondrocyte redox and mitochondrial physiology, leading to the development of promising disease-modifying therapies for posttraumatic osteoarthritis.

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  1. University of Iowa, 1182 Biomedical Laboratories, 500 Newton Road, Iowa City, 52242, USA

    Piedad C. Gomez-Contreras, Paige N. Kluz, Madeline R. Hines & Mitchell C. Coleman

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  1. Piedad C. Gomez-Contreras
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Gomez-Contreras, P.C., Kluz, P.N., Hines, M.R. et al. Intersections Between Mitochondrial Metabolism and Redox Biology Mediate Posttraumatic Osteoarthritis. Curr Rheumatol Rep 23, 32 (2021). https://doi.org/10.1007/s11926-021-00994-z

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