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Aiming for Cure and Preventive Initiatives in Psoriatic Disease: Building Synergy at NPF, GRAPPA, and PPACMAN

Abstract

Purpose of Review

To provide a general overview of the organizations dedicated to advance clinical and translational research in the field of psoriatic disease and to describe the current and future opportunities for team science approaches to overcome unmet needs in the field. Descriptions of initiatives from the NPF, PPACMAN, and GRAPPA are summarized.

Recent Findings

Program projects have recently identified areas of knowledge gaps in diagnosis, treatment, and prevention of psoriasis and psoriatic arthritis (PsA). NPF’s Psoriasis Prevention Initiative aims to identify interventions that can prevent the onset and relapse of psoriatic disease or related comorbidities. The Psorcast Study is a joint venture between PPACMAN and Sage Bionetworks based on patient-generated smartphone measurements of psoriatic disease. Similarly, GRAPPA is involved in a number of projects related to axial PsA, enthesitis prevalence, and biomarker discoveries.

Summary

As important initiatives bring new targets for diagnosis and therapeutics in psoriatic disease, supra-endeavors such as the NIH-Accelerating Medicines Partnership (AMP) and the European Innovative Medicines Initiative (IMI) are promising public-private partnerships that can significantly catapult the field forward.

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Funding

NIH/NIAMS R01AR074500-01A, National Psoriasis Foundation PsA Diagnostic Challenge and Psoriasis Prevention Initiative Grants, The Riley Family Foundation and The Snyder Family Foundation (Scher); NIH U01-AI119125, National Psoriasis Foundation Diagnostic Challenge Grant (Liao).

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Correspondence to Jose U. Scher.

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Conflict of Interest

UCB, Janssen, Abbvie, Pfizer, Novartis, Sanofi, BMS (Scher); AbbVie, Amgen, BMS, Celgene, Janssen, Lilly, Novartis, Pfizer, Corrona (Ogdie); AbbVie, Lilly, Janssen, Novartis, BMS, Pfizer, Amgen, UCB (FitzGerald); Abbvie, Amgen, Janssen, Novartis, Pfizer, Regeneron, and TRex Bio (Liao)BMS, Abbvie, Dermavant, Lilly, Novartis, Janssen, UCB, Sun Pharma, Pfizer, EMD Sorono (Merola). Novartis, Janssen, Pfizer, Otsuka (Webster).

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This article is part of the Topical Collection on Psoriatic Arthritis

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Bell, S., Merola, J.F., Webster, D.E. et al. Aiming for Cure and Preventive Initiatives in Psoriatic Disease: Building Synergy at NPF, GRAPPA, and PPACMAN. Curr Rheumatol Rep 22, 78 (2020). https://doi.org/10.1007/s11926-020-00958-9

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  • DOI: https://doi.org/10.1007/s11926-020-00958-9

Keywords

  • Psoriasis
  • Psoriatic arthritis
  • Prevention
  • Cure
  • Precision medicine