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Health-Related Quality of Life in Antiphospholipid Syndrome: Current Knowledge and Future Perspectives

  • Antiphospholipid Syndrome (S Zuily, Section Editor)
  • Published:
Current Rheumatology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Antiphospholipid syndrome (APS) is a chronic autoimmune disease that can be seen as a burden, with consequences on patients’ daily life. Health has traditionally been measured using measures of morbidity or mortality. Health-related quality of life (HRQoL) is a concept that includes quality of life through physical, mental, and social domains. As in other autoimmune diseases, HRQoL has been investigated in patients with APS. Here, we provide a comprehensive review of the current knowledge of the assessment of HRQoL in APS.

Recent Findings

APS patients have an impaired HRQoL compared with the general population. The presence of systemic lupus erythematosus (SLE) in APS patients is associated with a worse HRQoL than in patients without SLE. Several determinants of HRQoL impairment in APS have been identified: age, gender, history of arterial thrombosis, organ damage, lack of social support and treatments.

Summary

This review highlights the negative impact of thrombosis on APS patients’ HRQoL that should not be neglected. Besides, there is a need for a better strategy of communication and information, in order to improve HRQoL in APS.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. Université de Lorraine, Inserm, DCAC and CHRU-Nancy, Vascular Medicine Division and Regional Competence Center for Rare Auto-Immune Diseases, F-54000, Nancy, France

    Marie Desnoyers, Virginie Dufrost, Denis Wahl & Stéphane Zuily

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  1. Marie Desnoyers
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  2. Virginie Dufrost
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  3. Denis Wahl
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  4. Stéphane Zuily
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Correspondence to Stéphane Zuily.

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This article is part of the Topical Collection on Antiphospholipid Syndrome

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Desnoyers, M., Dufrost, V., Wahl, D. et al. Health-Related Quality of Life in Antiphospholipid Syndrome: Current Knowledge and Future Perspectives. Curr Rheumatol Rep 22, 20 (2020). https://doi.org/10.1007/s11926-020-00900-z

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