Eosinophilic Granulomatosis With Polyangiitis: Newer Therapies

Vasculitis (L Espinoza, Section Editor)
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Abstract

Purpose of review

Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic disseminated vasculitis associated with extravascular granulomas in patients suffering from asthma and tissue eosinophilia. Current therapies to achieve remission and prevent relapse include glucocorticoids and immunosuppressants like cyclophosphamide.

Recent findings

With the right treatment, clinical prognosis is favorable, so concerted efforts have been made in recent years to find new alternatives for treating severe EGPA. Monoclonal antibodies such as omalizumab, rituximab, and mepolizumab are among these new options.

Summary

This review summarizes the pathogenesis and clinical manifestations of EGPA and critically examines current and emerging therapies.

Keywords

Churg−Strauss syndrome Therapeutics Rituximab Omalizumab Mepolizumab 

Notes

Compliance With Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Erika P. Navarro-Mendoza
    • 1
  • Gabriel J. Tobón
    • 1
    • 2
  1. 1.GIRAT: Grupo de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Fundación Valle del LiliUniversidad IcesiCaliColombia
  2. 2.Immunology LaboratoryFundación Valle del LiliCaliColombia

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