The Duality of Economic Issues With Medication Non-adherence in Patients With Inflammatory Arthritis

  • Natasha K. J. Campbell
  • Khalid Saadeldin
  • Mary A. De Vera
Health Economics and Quality of Life (N Tsao, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Health Economics and Quality of Life


Purpose of Review

In this review, we synthesize current data on non-adherence across inflammatory arthritides and explore (1) the effects of economic factors on non-adherence and (2) the impacts of non-adherence on economic outcomes.

Recent Findings

Recent evidence demonstrates medication non-adherence rates as high as 74% in ankylosing spondylitis (AS), 90% in gout, 50% in psoriatic arthritis (PsA), 75% in systemic lupus erythematosus (SLE), and 82% in rheumatoid arthritis (RA).


The effects of socioeconomic factors have been studied most in RA and SLE but with inconsistent findings. Nonetheless, the evidence points to having prescription coverage and costs of treatment as important factors in RA and education as an important factor in SLE. Limited data in AS and gout, and no studies of the effects of socioeconomic factors in PsA, show knowledge gaps for future research. Finally, there is a dearth of data with respect to the impacts of non-adherence on economic outcomes.


Inflammatory arthritis Adherence Patient compliance Health economics Costs 


Compliance with Ethical Standards

Funding and Grant Support

Dr. De Vera is the Canada Research Chair in Medication Adherence, Utilization, and Outcomes and is a recipient of The Arthritis Society Network Scholar Award and Michael Smith Foundation for Health Research Scholar Award.

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Natasha K. J. Campbell
    • 1
    • 2
  • Khalid Saadeldin
    • 1
    • 2
  • Mary A. De Vera
    • 1
    • 2
    • 3
  1. 1.Faculty of Pharmaceutical SciencesUniversity of British ColumbiaVancouverCanada
  2. 2.Collaboration for Outcomes Research and EvaluationVancouverCanada
  3. 3.Arthritis Research CanadaRichmondCanada

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