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Pulmonary Involvement in Systemic Vasculitis

  • Vasculitis (L Espinoza, Section Editor)
  • Published:
Current Rheumatology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The purpose of this study is to describe the most relevant advances concerning lung involvement in the ANCA-associated vasculitides (excluding eosinophilic granulomatosis with polyangiitis which may have different disease mechanisms). Focus is on pathophysiology, recent important imagenological procedures, treatment, and outcome.

Recent Findings

Emerging information exists on potential newly investigated diagnostic procedures (v.g. transbronchial cryobiopsies), detailed tomographic abnormalities, the potential favorable role of rituximab and the still uncertain one of plasma exchange in the treatment, and the increasing description of interstitial lung disease. Survival is reduced in case of both, diffuse alveolar hemorrhage and diffuse parenchymal disease.

Summary

There is the need to expand the knowledge concerning better long-term treatment options with specific regimes, and to incorporate other measures regarding integral treatment in patients afflicted with lung involvement these maladies, as the outcome seems adverse in this scenario.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Author information

Authors and Affiliations

  1. Primary Systemic Vasculitides Clinic, Instituto Nacional de Enfermedades Respiratorias, Calzada de Tlalpan 4502, Col. Sección XVI, Tlalpan, Mexico City, Mexico

    Luis Felipe Flores-Suárez & Natllely Ruiz

  2. Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA

    Marco A. Alba

  3. Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico

    Heidegger Mateos-Toledo

Authors
  1. Luis Felipe Flores-Suárez
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  2. Marco A. Alba
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  3. Heidegger Mateos-Toledo
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  4. Natllely Ruiz
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Corresponding author

Correspondence to Luis Felipe Flores-Suárez.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Vasculitis

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Flores-Suárez, L.F., Alba, M.A., Mateos-Toledo, H. et al. Pulmonary Involvement in Systemic Vasculitis. Curr Rheumatol Rep 19, 56 (2017). https://doi.org/10.1007/s11926-017-0682-4

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  • DOI: https://doi.org/10.1007/s11926-017-0682-4

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