Neonatal Lupus: What We Have Learned and Current Approaches to Care


Neonatal lupus results from the passive transfer of autoantibodies; however, this transfer is not sufficient to cause disease. This article reviews clinical presentation with a focus on autoimmune-mediated congenital heart disease. Recent data looking for additional disease mechanisms and biomarkers as well as latest information on interventions will be reviewed. Our understanding of this rare disease is often dependent on patient participation in disease registries and biorepositories. Future participation in registries including descriptive as well as biophysical data is critical to our knowledge.

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Corresponding author

Correspondence to Marisa S. Klein-Gitelman.

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Conflict of Interest

MSKG reports grants from Alliance for Lupus Research, Lupus Foundation of America, and NIAMS, outside the submitted work.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by the author (MSKG).

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This article is part of the Topical Collection on Pediatric Rheumatology

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Klein-Gitelman, M.S. Neonatal Lupus: What We Have Learned and Current Approaches to Care. Curr Rheumatol Rep 18, 60 (2016).

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  • Neonatal lupus
  • Passive immune injury
  • Autoimmune-mediated congenital heart disease
  • Patient registries