The clinical presentation of Cogan’s syndrome has been classified as typical and atypical. Like other forms of ocular vasculitis, Cogan’s syndrome has been found to have autoimmune origins with antibodies against the cornea, inner ear, and endothelial antigens. Antineutrophil cytoplasmic antibody (ANCA) and rheumatoid factor (RF) have been associated with Cogan’s syndrome as well as ocular-involving vasculitides not as strongly associated with the audiovestibular manifestations such as granulomatosis with polyangiitis and rheumatoid arthritis. The mainstay of therapy has been corticosteroids although other methods have been described in recalcitrant disease and to prevent development of systemic sequelae.
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Gabriela M. Espinoza and Angela Prost declare that they have no conflicts of interest.
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This article does not contain any studies with human or animal subjects performed by any of the authors.
This article is part of the Topical Collection on Vasculitis
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Espinoza, G.M., Prost, A. Cogan’s Syndrome and Other Ocular Vasculitides. Curr Rheumatol Rep 17, 24 (2015). https://doi.org/10.1007/s11926-015-0499-y
- Cogan syndrome
- Autoimmune disease
- Hearing loss
- Rheumatoid arthritis
- Granulomatosis with polyangiitis