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What Do Cytokine Profiles Tell Us About Subsets of Juvenile Idiopathic Arthritis?

  • PEDIATRIC RHEUMATOLOGY (TJA LEHMAN, SECTION EDITOR)
  • Published:
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Abstract

Classification of juvenile idiopathic arthritis is an ongoing process and up to now has been predominantly based on clinical manifestations—mainly number of joints at onset of disease. In the meantime, basic studies have advanced our knowledge regarding the disease pathogenesis. Unfortunately, studies of cytokines and cytokine polymorphisms have not followed the predominantly clinical International League of Associations for Rheumatology classification in that no significant biological differences among the different disease categories have been demonstrated with robust associations. Only systemic-onset disease seems to be quite different from other disease categories with regard to biologic mechanisms; indeed, it now seems closer to autoinflammatory than to classic autoimmune diseases. New players in the immunologic basis of juvenile idiopathic arthritis (eg, interleukin-17 and regulatory T cells) are also discussed in this review.

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Papers of particular interest, published recently, have been highlighted as: • Of importance

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No potential conflicts of interest relevant to this article were reported.

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Authors and Affiliations

  1. AOU Meyer, Viale Pieraccini 24, 50139, Firenze, Italy

    Rolando Cimaz, Davide Moretti, Ilaria Pagnini, Achille Marino & Gabriele Simonini

  2. Rheumatology Unit, Siena, Italy

    Luca Cantarini

Authors
  1. Rolando Cimaz
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  2. Davide Moretti
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  3. Ilaria Pagnini
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  4. Achille Marino
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  5. Luca Cantarini
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  6. Gabriele Simonini
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Correspondence to Rolando Cimaz.

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Cimaz, R., Moretti, D., Pagnini, I. et al. What Do Cytokine Profiles Tell Us About Subsets of Juvenile Idiopathic Arthritis?. Curr Rheumatol Rep 14, 150–154 (2012). https://doi.org/10.1007/s11926-011-0233-3

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  • DOI: https://doi.org/10.1007/s11926-011-0233-3

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